CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 29, 2025

Colorectal cancer (CRC) is one of the leading causes cancer-related mortality worldwide. In recent years, circular RNAs (circRNAs), a novel class non-coding RNA molecules, have emerged as research focus due to their unique stability and functional roles. CircRNAs regulate tumor-related signaling pathways through interactions with microRNAs (miRNAs) proteins, playing key roles in tumorigenesis, progression, invasion, metastasis, chemoresistance. This review summarizes role circRNAs CRC, particularly mechanisms cell proliferation, migration, apoptosis, tumor microenvironment (TME) remodeling, immune evasion. Aberrant expression holds great potential diagnostic prognostic biomarkers well therapeutic targets for CRC. Additionally, natural products such flavonoids glycosides, by modulating circRNA-miRNA-mRNA networks, offer promising strategies. The article also discusses current technical challenges circRNA its future application prospects highlighting need further investigation into microenvironments drug resistance mechanisms.

Language: Английский

LncRNA LINC01128 promotes prostate cancer cell proliferation, metastasis, and epithelial-mesenchymal transition by modulating miR-27b-3p

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(3)

Published: March 4, 2025

Language: Английский