Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: May 9, 2025

Targeting the balance of mitochondrial fission and fusion can effectively alleviate cardiac energy supply efficiency, to restore systolic dysfunction reduce mortality. We previously found that Klf7 is closely related metabolism. Here we generated cardiomyocyte-specific knockout overexpression mice underwent myocardial infarction (MI) surgery. expression increased in ischemic myocardium mice, significantly lowered mortality MI-inflicted improved ATP insufficiency MI. Subsequently, aggravated adverse remodeling imbalance after Our results also demonstrated inhibited promoted by targeting prohibitin 2 (Phb2) mitofusin (Mfn2). study revealed a crucial role upholding overall during Furthermore, our findings indicated Klf7/Mfn2/Phb2 axis holds promise as potential target for therapeutic interventions

Language: Английский