Bioactive Compounds from Plant Origin as Natural Antimicrobial Agents for the Treatment of Wound Infections

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2100 - 2100

Published: Feb. 8, 2024

The rising prevalence of drug-resistant bacteria underscores the need to search for innovative and nature-based solutions. One approaches may be use plants that constitute a rich source miscellaneous compounds with wide range biological properties. This review explores antimicrobial activity seven bioactives their possible molecular mechanisms action. Special attention was focused on antibacterial properties berberine, catechin, chelerythrine, cinnamaldehyde, ellagic acid, proanthocyanidin, sanguinarine against Staphylococcus aureus, Enterococcus spp., Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli, Serratia marcescens Pseudomonas aeruginosa. growing interest in novel therapeutic strategies based new plant-derived formulations confirmed by number articles. Natural products are one most promising intensively examined agents combat consequences overuse misuse classical antibiotics.

Language: Английский

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Network segregation and the propagation of misinformation

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Jan. 17, 2023

Abstract How does the ideological segregation of online networks impact spread misinformation? Past studies have found that homophily generally increases diffusion, suggesting partisan news, whether true or false, will farther in ideologically segregated networks. We argue network disproportionately aids messages are otherwise too implausible to diffuse, thus favoring false over news. To test this argument, we seeded and informational experimental which subjects were either integrated segregated, yielding 512 controlled propagation histories 16 independent information systems. Experimental results reveal fraction circulating was systematically greater Agent-based models show robustness finding across different topologies sizes. conclude sorting undermines veracity on Internet by increasing exposure content would not manage diffuse.

Language: Английский

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The role of vaccine status homophily in the COVID-19 pandemic: a cross-sectional survey with modelling

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 14, 2024

Abstract Background Vaccine homophily describes non-heterogeneous vaccine uptake within contact networks. This study was performed to determine observable patterns of homophily, as well the impact on disease transmission and between vaccination groups under conditions high low efficacy. Methods Residents British Columbia, Canada, aged ≥ 16 years, were recruited via online advertisements February March 2022, provided information about status, perceived status household non-household contacts, compliance with COVID-19 prevention guidelines, history COVID-19. A deterministic mathematical model used assess dynamics Results observed among those 0, 2, or 3 doses vaccine. Greater who had more ( p < 0.0001). Those fewer larger networks 0.0001), likely report prior reported lower guidelines Mathematical modelling showed that plays a considerable role in epidemic growth Furthermore, contributes force infection unvaccinated individuals efficacy, an elevated from suboptimally vaccinated Interpretation The uneven vaccines nature network population play important roles shaping dynamics.

Language: Английский

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COVID-19 vaccine hesitancy among adults in India: A primary study based on health behavior theories and 5C psychological antecedents model

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0294480 - e0294480

Published: May 9, 2024

Despite the significant success of India’s COVID-19 vaccination program, a sizeable proportion adult population remains unvaccinated or has received single dose vaccine. recommendations Government India for two doses vaccine and precautionary booster dose, many people were still hesitant towards full vaccination. Hence, this study aimed to identify primary behavioral psychological factors contributing hesitancy. Cross-sectional data was collected via multi-stage sampling design by using scheduled sample survey in Gorakhpur district Uttar Pradesh, India, between 15 July 2022 30 September 2022. This utilized three health behavior models—the Health Belief Model (HBM) , Theory Planned Behavior (TPB) 5C Psychological Antecedents vaccination, employed bivariate multivariable binary logistic regression model assess level hesitancy predictive respondents. Results indicate that among constructs HBM models, "perceived benefits", "confidence" "collective responsibility" showed lesser likelihood However, TPB constructs, ‘negative attitude vaccine’ four times higher From future policy perspective, suggested addressing issue attitudes increasing trust confidence through awareness about benefits may reduce

Language: Английский

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Identifying H1N1 and COVID-19 vaccine hesitancy or refusal among health care providers: a scoping review

JBI Evidence Synthesis, Journal Year: 2023, Volume and Issue: unknown

Published: March 14, 2023

Objectives: The objective of this review was to describe and map the evidence around COVID-19 H1N1 vaccine hesitancy or refusal by physicians, nurses, pharmacists in North America, United Kingdom European Union, Australia. Introduction: Since 2009, we have experienced two pandemics: “swine flu” COVID-19. While severity transmissibility these viruses has varied, vaccination been a critical component bringing both pandemics under control. However, uptake vaccines affected refusal. behaviors health care providers, including pharmacists, are particular interest as they priority populations receive vaccinations, their views could affect decisions patients. Inclusion criteria: Studies were eligible for inclusion if identified reasons among and/or from included countries. Published unpublished literature inclusion. Previous reviews excluded; however, reference lists relevant searched identify additional studies Methods: A search CINAHL, MEDLINE, PsycINFO, Academic Search Premier databases conducted April 28, 2021, English-language published 2009 2021. Gray citation screening also literature. Titles, abstracts, full-text articles reviewed duplicate 2 trained reviewers. Data extracted using structured extraction tool developed review. Conflicts resolved through discussion with third team member. synthesized narrative tabular summaries. Results: In total, 83 primarily across States, Kingdom, France. majority (n=70) used cross-sectional designs examine knowledge, attitudes, (n=61) (n=22) vaccines. Physicians, medical students, nursing students common participants studies, only 8 sample. Across settings, most urban, academic teaching hospitals, 1 study rural hospital setting. Concerns about safety, side effects, perceived low risk contracting Conclusions: With increased attention on recent years, intensified pandemic, more research that examines different settings providers is warranted. Future work should aim utilize qualitative mixed methods capture personal perspectives refusal, consider collecting data beyond urban

Language: Английский

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Evacuation Decision-Making Post-COVID-19 Vaccine Availability: Implications of Compound Hazards in Puerto Rico and the US Virgin Islands

Disaster Medicine and Public Health Preparedness, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 1, 2025

Abstract Objective The threat of novel pathogens and natural hazards is increasing as global temperatures warm, leading to more frequent severe occurrences infectious disease outbreaks major hurricanes. COVID-19 pandemic amplified the need examine how risk perceptions related hurricane evacuations shift when vaccines become available. This study explores individuals’ expected evacuation plans during early stages vaccine availability. Methods In March 2021, an online survey was disseminated in Puerto Rico US Virgin Islands. Results An overwhelming majority (72.6%) respondents said that their vaccination status would not affect intentions. unvaccinated were significantly likely consider evacuating a than vaccinated. Even with available, suggested they less evacuate shelter 2021 season prior pandemic. Respondents generally believed contracting at greater sheltering-in-place hurricane. Conclusions Government officials develop communicate clear information regarding orders for municipalities may be impacted others based on trajectory storm, social determinants health, other factors like living flood zone.

Language: Английский

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Association of death or illness from COVID-19 among family and friends on vaccine uptake within four months of the Emergency Use Authorization. Findings from a national survey in the United States

Vaccine, Journal Year: 2023, Volume and Issue: 41(12), P. 1911 - 1915

Published: Jan. 13, 2023

Language: Английский

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Assessing the Impact of Vaccination on the Dynamics of COVID-19 in Africa: A Mathematical Modeling Study

Vaccines, Journal Year: 2023, Volume and Issue: 11(4), P. 857 - 857

Published: April 17, 2023

Several effective COVID-19 vaccines are administered to combat the pandemic globally. In most African countries, there is a comparatively limited deployment of vaccination programs. this work, we develop mathematical compartmental model assess impact programs on curtailing burden in eight countries considering SARS-CoV-2 cumulative case data for each country third wave pandemic. The stratifies total population into two subgroups based individual status. We use detection and death rates ratios between vaccinated unvaccinated individuals quantify vaccine’s effectiveness reducing new infections death, respectively. Additionally, perform numerical sensitivity analysis combined reduction transmission due control measures reproduction number (Rc). Our results reveal that average, at least 60% considered should be curtail (lower Rc below one). Moreover, lower values possible even when low (10%) or moderate (30%) rate NPIs. Combining with various levels NPI aids study shows significantly reduces severity disease despite efficacy against infections. governments need design strategies increase vaccine uptake, such as an incentive-based approach.

Language: Английский

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Differentiating behavioral impact with or without vaccination certification under mass vaccination and non-pharmaceutical interventions on mitigating COVID-19

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 6, 2024

Abstract As COVID-19 vaccines became widely available worldwide, many countries implemented vaccination certification, also known as a “green pass”, to promote and expedite on containing virus spread from the latter half of 2021. This policy allowed those vaccinated have more freedom in public activities compared constraints unvaccinated addition existing non-pharmaceutical interventions (NPIs). Accordingly, certification induced heterogeneous behaviors groups. makes it essential yet challenging model behavioral impact two groups transmission dynamics within between Very limited quantitative work is for addressing these purposes. Here we propose an extended epidemiological SEIQRD $$^2$$ 2 effectively distinguish through incorporating contrastive chains. quantifies green pass policy. With resurgence Greece, Austria, Israel 2021, our simulation results indicate that their implementation brought about than 14-fold decrease total number infections deaths scenario with no such Additionally, may offer reasonable practical solution strike balance health individual’s during pandemic.

Language: Английский

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Impact of immune evasion, waning and boosting on dynamics of population mixing between a vaccinated majority and unvaccinated minority

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(4), P. e0297093 - e0297093

Published: April 4, 2024

We previously demonstrated that when vaccines prevent infection, the dynamics of mixing between vaccinated and unvaccinated sub-populations is such use imperfect markedly decreases risk for people, population overall. Risks to people accrue disproportionately from contact with people. In context emergence Omicron SARS-CoV-2 evolving understanding epidemiology, we updated our analysis evaluate whether earlier conclusions remained valid.

Language: Английский

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