Functional and microstructural neurosubstrates between apathy and depressive symptoms in dementia DOI Creative Commons
Sheng‐Min Huang, Yen‐Hsuan Hsu,

Jir‐Jei Yang

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103781 - 103781

Published: April 1, 2025

The overlapping features of depressive symptoms and apathy hinder their differentiation in clinical practice, hence a greater understanding neurosubstrates dementia its subtypes is necessary. Ninety-two patients (Alzheimer's disease [AD, n = 52]; subcortical ischemic vascular [SIVD, 40]), 30 cognitively normal subjects were evaluated using the Apathy Evaluation Scale (AES), Beck's Depression Inventory (BDI), brain magnetic resonance imaging (MRI). Grouped by AES/BDI scores, hubs depression/apathy identified comparing MRI metrics including fractional amplitude low-frequency fluctuation (fALFF) resting-state functional MRI, mean kurtosis (MK) diffusion imaging. Associations between with analyzed. Comparing low-AES high-AES groups, fALFF indicated pervasive changes mainly within default mode network (DMN) frontoparietal (FPN). low-BDI high-BDI reflected DMN, FPN, salience (SAN). Contrarily, MK showed focal DMN SAN regions from same group-wise comparisons. While was more correlated DMN/FPN for AES than BDI significantly SIVD AD, left anterior cingulate cortex right insula BDI, but AD (all P < 0.01). Topologically, centered at posterior poles, respectively. These findings suggest that dual-modal could reflect distinct neuropathological basis SIVD.

Language: Английский

Neurophysiological Markers of Regulation Success in Everyday Life in Depression DOI
Jonathan P. Stange, Ellie Xu, Sarah L Zapetis

et al.

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Lower functional connectivity state transitions during affective processing correlate with subsequent impairment in sustaining positive affect in subthreshold depression DOI Creative Commons
Xiaoqi Song,

Lijing Niu,

Jonathan P. Roiser

et al.

International Journal of Clinical and Health Psychology, Journal Year: 2025, Volume and Issue: 25(1), P. 100560 - 100560

Published: Jan. 1, 2025

Language: Английский

Citations

0
Functional and microstructural neurosubstrates between apathy and depressive symptoms in dementia DOI Creative Commons
Sheng‐Min Huang, Yen‐Hsuan Hsu,

Jir‐Jei Yang

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: unknown, P. 103781 - 103781

Published: April 1, 2025

The overlapping features of depressive symptoms and apathy hinder their differentiation in clinical practice, hence a greater understanding neurosubstrates dementia its subtypes is necessary. Ninety-two patients (Alzheimer's disease [AD, n = 52]; subcortical ischemic vascular [SIVD, 40]), 30 cognitively normal subjects were evaluated using the Apathy Evaluation Scale (AES), Beck's Depression Inventory (BDI), brain magnetic resonance imaging (MRI). Grouped by AES/BDI scores, hubs depression/apathy identified comparing MRI metrics including fractional amplitude low-frequency fluctuation (fALFF) resting-state functional MRI, mean kurtosis (MK) diffusion imaging. Associations between with analyzed. Comparing low-AES high-AES groups, fALFF indicated pervasive changes mainly within default mode network (DMN) frontoparietal (FPN). low-BDI high-BDI reflected DMN, FPN, salience (SAN). Contrarily, MK showed focal DMN SAN regions from same group-wise comparisons. While was more correlated DMN/FPN for AES than BDI significantly SIVD AD, left anterior cingulate cortex right insula BDI, but AD (all P < 0.01). Topologically, centered at posterior poles, respectively. These findings suggest that dual-modal could reflect distinct neuropathological basis SIVD.

Language: Английский

Citations

0