Antiviral and antibacterial properties of phloroglucinols: a review on naturally occurring and (semi)synthetic derivatives with potential therapeutic interest DOI
Gregorio Peron,

Alice M. López,

Paulina Cabada-Aguirre

et al.

Critical Reviews in Biotechnology, Journal Year: 2023, Volume and Issue: 44(2), P. 319 - 336

Published: Jan. 2, 2023

Phloroglucinol and derived compounds comprise a huge class of secondary metabolites widely distributed in plants brown algae. A vast array biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer has been associated to this compounds. In review, the available data on antiviral antibacterial capacity phloroglucinols have analyzed. Some these derivatives show important antimicrobial properties vitro. Phloroglucinols shown be effective against viruses, such as human immunodeficiency virus (HIV), herpes or enterovirus, preliminary through docking analysis suggest that they can SARS-CoV-19. Also, some effects diverse bacteria strains, Bacillus subtilis Staphylococcus aureus, (semi)synthetic development novel led with significantly increased activity. However, therapeutic use is hindered by absence vivo studies scarcity information their mechanisms action, hence further research efforts are required. On basis consideration, our work aims gather regarding efficacy natural-occurring synthetic phloroglucinol agents pathogens, which published during last three decades. The recollection results reported review represents valuable source updated will potentially help researchers agents.

Language: Английский

Bioactive compounds from sea sponges in Tobago exhibit growth inhibitory activity against Staphylococcus aureus and Escherichia coli compared to Amoxiclav DOI Creative Commons
Sani Ismaila Muhammad, Reia Guppy,

Amorette Fraites

et al.

Journal of Taibah University for Science, Journal Year: 2025, Volume and Issue: 19(1)

Published: Feb. 10, 2025

Language: Английский

Citations

0
An Eco-sustainable and Circular Economy—Benefits and Constraints DOI
João Cotas, Silvia Lomartire,

Madalena Mendes

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Importance of quorum sensing crosstalk in the brown alga Saccharina latissima epimicrobiome DOI Creative Commons
Émilie Adouane, Camille Mercier,

Jeanne Mamelle

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(3), P. 109176 - 109176

Published: Feb. 9, 2024

Brown macroalgae are colonized by diverse microorganisms influencing the physiology of their host. However, cell-cell interactions within surface microbiome (epimicrobiome) largely unexplored, despite significance specific chemical mediators in maintaining host-microbiome homeostasis. In this study, combining liquid chromatography coupled to mass spectrometry (LC-MS) analysis and bioassays, we demonstrated that widely fungal epimicrobiota brown alga

Language: Английский

Citations

3
Antioxidant and Antimicrobial Properties of Selected Red Seaweeds from Central Portugal DOI Creative Commons
Marta V. Freitas, Leonardo G. Inácio, Ana Ruas

et al.

Applied Sciences, Journal Year: 2022, Volume and Issue: 13(1), P. 157 - 157

Published: Dec. 22, 2022

Throughout the ages, macroalgae have provided humankind with elements beneficial to human health, and often bioactive abilities. Yet, while today we fully acknowledge such potential, especially that of most widely known species, an even greater number species remain unaknowledged. This holds particularly true for highly diverse phylum Rhodophyta (red seaweeds) and, therefore, present study aims unveil antioxidant antimicrobial potential twelve red seaweed collected in central Portugal. Results obtained from assays ABTS TPC highlighted high scavenging capacity coralline algae Corallina officinalis, Ellisolandia elongata Amphiroa rigida, phenolic content Porphyra umbilicalis, whereas analyses through MIC determination emphasized activities Sphaerococcus coronopifolius Mesophyllum lichenoides against, respectively, Bacillus subtilis Saccharomyces cerevisiae. raised awareness waiting be discovered regarding less as rigida lichenoides. Therefore, believe this provides extra steps pinpointing encouraging further studies tailored toward a biotechnological perspective, ultimately, influencing current perspectives exploration seaweeds.

Language: Английский

Citations

12
Antiviral and antibacterial properties of phloroglucinols: a review on naturally occurring and (semi)synthetic derivatives with potential therapeutic interest DOI
Gregorio Peron,

Alice M. López,

Paulina Cabada-Aguirre

et al.

Critical Reviews in Biotechnology, Journal Year: 2023, Volume and Issue: 44(2), P. 319 - 336

Published: Jan. 2, 2023

Phloroglucinol and derived compounds comprise a huge class of secondary metabolites widely distributed in plants brown algae. A vast array biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer has been associated to this compounds. In review, the available data on antiviral antibacterial capacity phloroglucinols have analyzed. Some these derivatives show important antimicrobial properties vitro. Phloroglucinols shown be effective against viruses, such as human immunodeficiency virus (HIV), herpes or enterovirus, preliminary through docking analysis suggest that they can SARS-CoV-19. Also, some effects diverse bacteria strains, Bacillus subtilis Staphylococcus aureus, (semi)synthetic development novel led with significantly increased activity. However, therapeutic use is hindered by absence vivo studies scarcity information their mechanisms action, hence further research efforts are required. On basis consideration, our work aims gather regarding efficacy natural-occurring synthetic phloroglucinol agents pathogens, which published during last three decades. The recollection results reported review represents valuable source updated will potentially help researchers agents.

Language: Английский

Citations

7