COVID-19 and its long-term sequelae: what do we know in 2023?

Polskie Archiwum Medycyny Wewnętrznej, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 9, 2023

Post‑viral syndrome is a well‑known medical condition characterized by different levels of physical, cognitive, and emotional impairment that may persist with fluctuating severity after recovering from an acute viral infection. Unsurprisingly, COVID‑19 also be accompanied medium- long‑term clinical sequelae SARS‑CoV‑2 Although many definitions have been provided, "long‑COVID" can defined as occurring in patients history infection, developing 3 months the symptoms onset, persisting for at least 2 months, not explained alternative diagnoses. According to recent global analyses, cumulative prevalence long‑COVID seems range between 9% 63%, up 6‑fold higher than similar postviral infection conditions. Long‑COVID primarily encompasses presence 1 symptom, such fatigue, dyspnea, cognitive / brain fog, postexertional malaise, memory issues, musculoskeletal pain spasms, cough, sleep disturbances, tachycardia palpitations, altered smell taste perception, headache, chest pain, depression. The most important demographic predictors date are female sex, older age, cigarette smoking, pre‑existing conditions, lack vaccination, pre‑Omicron variants, number phase symptoms, load, severe critical illness, well invasive mechanical ventilation. Concerning care patients, greatest challenge fact this cannot considered single entity, thus it needs integrated multidisciplinary management, specifically tailored type symptoms.

Language: Английский

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Mortality of Post-COVID-19 Condition: 2025 Update

COVID, Journal Year: 2025, Volume and Issue: 5(1), P. 11 - 11

Published: Jan. 14, 2025

Background: The coronavirus disease 2019 (COVID-19) pandemic has generated profound health, societal, and economic consequences, which have been further compounded by long-term sequelae commonly referred to as post-COVID-19 or long-COVID syndrome. Understanding the real-world impact of mortality is therefore critical for effective healthcare planning resource allocation. Methods: A descriptive epidemiological study was conducted using data from US National Center Health Statistics identify deaths attributed condition, classified ICD-10 code U09.9, October 2021 December 2024. Demographic factors such gender, age, place death were also extracted. Results: By 2024, 2653 under corresponding an age-adjusted rate 0.089 × 100,000. Mortality significantly higher in males compared females (0.098 vs. 0.081 100,000; p < 0.001). clear age-related gradient observed, with rates increasing almost linearly advancing age. largest fraction occurred at home (33.0%), followed nursing homes (26.3%) medical facilities (24.1%). Conclusions: These findings highlight substantial yet complex condition on mortality, observed males, older adults, individuals home, highlighting need targeted interventions allocation, particularly these higher-risk groups.

Language: Английский

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Cost-effectiveness analysis of different COVID-19 screening strategies based on rapid or laboratory-based SARS-CoV-2 antigen testing

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2023, Volume and Issue: 61(9), P. e168 - e171

Published: Feb. 27, 2023

To the Editor, Now, in fourth year of coronavirus disease 2019 (COVID-19) pandemic, many important aspects have become clear concerning pathogenesis, clinical management, outcome and, last but not least, regarding diagnostic approach to severe acute respiratory syndrome 2 (SARS-CoV-2) infection.Although it is undeniable that consequences an SARS-CoV-2 infection general population are incomparably milder now compared period when virus initially spread worldwide from China [1], number daily COVID-19 diagnoses still very high.According World Health Organization (WHO), new or recurrent cases exceeds 200,000 February 2023 [2].We also must acknowledge this may be heavily underestimated for a variety reasons discussed elsewhere [3].Thus, strategies only relying on molecular testing, although remaining gold standard detecting SARS-CoV-2, imprudent given reference real-time reverse transcription polymerase chain reaction (RT-PCR) assays characterized by low throughput, long turnaround time and high cost [4], thus paving way using alternative solutions.Among various options, identification quantification antigens means rapid tests (RDT-Ag) laboratory-based immunoassays (LAB-Ag) represent valuable alternatives, endorsed both WHO [5] International Federation Clinical Chemistry Laboratory Medicine [6].Although we certainly recognize sensitivity these basically lower than (i.e., comprised between 70 80%) [7, 8], their usage initial "screening" patients provide saving precious human economic resources, though no comprehensive information exists confirm validity second claim best our knowledge.To end, carried out cost-effective analysis some potential protocols inclusive antigen tests.The study consisted series 294 (mean age, 45 ± 20 years; 55% females) presenting facility Pederzoli Hospital Peschiera del Garda (Verona, Italy), undergo routine testing.According local operating procedures (SOPs), all underwent testing (RDT-Ag, ∼30 min time; Fujirebio Espline SARS-CoV-2; Inc., Tokyo, Japan) enabling fast positive subjects, followed (RT-PCR, 4-6 h Altona Diagnostics RealStar SARSCoV-2 RT-PCR Kit; GmbH, Hamburg, Germany) Ag (LAB-Ag, 45-60 DiaSorin LIAISON Ag; DiaSorin, Saluggia, Italy) same nasopharyngeal sample.The specific

Language: Английский

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Mortality from Pulmonary Embolism in Patients with Post-Coronavirus Disease Syndrome

Seminars in Thrombosis and Hemostasis, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

As of the most recent update in January 2025, World Health Organization (WHO) reported that over 777 million individuals worldwide have been infected at least once by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), virus responsible for disease 2019 (COVID-19).[1] These figures are likely underestimated owing to factors such as undertesting and underreporting, especially because widespread availability rapid diagnostic tests, which facilitate self-testing self-diagnosis, has further contributed many cases escaping official surveillance systems.[2]

Language: Английский

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Development of Bayesian segmented Poisson regression model to forecast COVID-19 dynamics based on wastewater data: a case study in Nanning City, China

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 9, 2025

Language: Английский

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Physical Activity, Long-COVID, and Inactivity: A Detrimental Endless Loop

Journal of Physical Activity and Health, Journal Year: 2024, Volume and Issue: 21(5), P. 420 - 422

Published: March 11, 2024

The risk of developing medium- and long-term sequelae after recovery from COVID-19 is validated. Long-COVID burden represents a major health care issue, thus paving the way to effective prevention and/or treatment measures. Physical activity prevents many human pathologies, including COVID-19. Being physically active before immediately severe acute respiratory syndrome coronavirus 2 infection substantially lowers long-COVID. In addition, long-COVID an important cause physical inactivity. Physically inactive individuals are at increased long-COVID, while patients with more likely reduce their levels recovering infection, generating continuous loop. This harmful interaction needs be recognized by public institutions, adoption as routine clinical practice in all proactively promoted.

Language: Английский

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COVID-19: Lessons from the Past to Inform the Future of Healthcare

COVID, Journal Year: 2024, Volume and Issue: 5(1), P. 4 - 4

Published: Dec. 26, 2024

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its global spread have left an indelible mark, disrupting multiple aspects human life. It is therefore crucial to retrospectively analyze the factors that contributed more initial inefficiency response, thus enhancing preparedness proactively addressing risk similar events occurring in future. Critical areas were identified based on our expertise. Relevant bibliographic references subsequently gathered through open search scientific databases substantiate concepts discussed this article. key issues hindered effective response disease 2019 (COVID-19) are numerous multifaceted, some these will be critically examined article, including delayed identification pathogen, inadequate public health preparedness, therapeutic management, deficiencies laboratory diagnostics. From analysis, for improvement emerge ensure efficient responses future crises, (i) strengthening information systems, (ii) improving pandemic planning, (iii) developing a resilient healthcare workforce, (iv) increasing investment research development, (v) expanding use telemedicine digital health, (vi) ensuring universal access healthcare, (vii) communication trust.

Language: Английский

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Diagnostic accuracy of Siemens SARS-CoV-2 Antigen (CoV2Ag) chemiluminescent immunoassay for diagnosing acute SARS-CoV-2 infection: a pooled analysis

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2023, Volume and Issue: 61(7), P. 1133 - 1139

Published: Jan. 12, 2023

Abstract Background This article provides a critical literature review and pooled analysis of diagnostic accuracy the fully-automated Siemens SARS-CoV-2 Antigen (CoV2Ag) chemiluminescent immunoassay for diagnosis acute infections. Methods An electronic search was conducted in Scopus, PubMed medRxiv using keywords [“Siemens AND CoV2Ag”] OR antigen”] capturing studies that investigated CoV2Ag diagnosing infection against reference molecular test. The retrieved information used constructing 2 × table calculating sensitivity, specificity, Summary Receiver Operating Characteristic Curve (SROC) Agreement. study followed PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) reporting checklist. Results Four totalling 1,310 respiratory samples (612 with high viral load) were finally included our analysis. cumulative area under curve, accuracy, 0.964 (95% CI, 0.957–0.971), 86.9% 84.9–88.7%), 0.79 0.76–0.82) 0.98 0.96–0.99), respectively. negative (NPV) positive (PPV) predictive values 0.77 (0.74–0.79) 0.96–99), sensitivity load (i.e., Ct<29–30) 0.95 0.93–0.97). Conclusions high-throughput approximates minimum performance criteria general antigen testing displays excellent load, thus representing valuable screening solution risk assessment COVID-19 limiting spread.

Language: Английский

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Update on the status of COVID-19 vaccination in Italy—April 2023

Immunologic Research, Journal Year: 2023, Volume and Issue: 71(5), P. 671 - 672

Published: April 20, 2023

Language: Английский

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Long-term sequelae of coronavirus disease: long COVID-19 and cardiovascular outcomes (a literature review)

Zaporozhye Medical Journal, Journal Year: 2024, Volume and Issue: 26(3), P. 223 - 233

Published: May 31, 2024

The COVID-19 pandemic has serious global implications for the healthcare system and economy. Although recovery rate increased significantly morbidity decreased, long-term consequences, particularly cardiovascular, have come to fore become a problem. As result, in 2021, at WHO level, concept of “long-term COVID” was introduced, including more than 100 already described symptoms patients least 3 months after initial recovery. At same time, clinical are not specific, strategies treatment such disorders been worked out, measures detect and/or prevent development these complications organized. aim: summarize available data modern views on cardiovascular effects COVID-19, reveal probable causes risk factors their development, as well analyze presented information pathogenetic mechanisms consequences coronavirus disease. literature analysis shown that SARS-CoV-2 viral persistence human body, reactivation other agents, immune dysregulation, autoimmunization occurrence microvascular thrombosis endothelial dysfunction among long COVID. all findings represent theoretical concepts regarding pathogenesis disease, complementing interacting with each other, moment, there is no formulated uniform explanation COVID-19. Also, large-scale studies point need special attention Among those myocarditis, pericarditis, heart failure, arterial hypertension, arrhythmias, pulmonary embolism, cerebrovascular disorders, cardiomyopathy. Given prevalence diseases impact mortality, processes threat context pandemic. Conclusions. COVID analyzed, COVID-related from acute disease examined detail. study this issue extremely important since only by understanding association between diseases, studying identifying factors, it possible improve prevention take control over level.

Language: Английский

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