The Need for Standardized Guidelines for the Use of Monocyte Distribution Width (MDW) in the Early Diagnosis of Sepsis DOI Open Access
Andrea Piccioni,

Fabio Spagnuolo,

Silvia Baroni

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 15(1), P. 5 - 5

Published: Dec. 27, 2024

Sepsis is a complex and potentially life-threatening syndrome characterized by an abnormal immune response to infection, which can lead organ dysfunction, septic shock, death. Early diagnosis crucial improving prognosis reducing hospital management costs. This narrative review aims summarize evaluate the current literature on role of monocyte distribution width (MDW) as diagnostic biomarker for sepsis, highlighting its advantages, limitations, potential clinical applications. MDW measures volumetric monocytes, reflecting monocytic anisocytosis, detected using advanced hematological analyzers. In 2019, it was approved FDA sepsis due ability identify systemic inflammatory at early stage. Thirty-one studies analyzed us have shown that increased value associated with higher risk combination parameters (such qSOFA) other biomarkers (CRP, PCT) enhance sensitivity stratification capacity. Despite high sensitivity, has lower specificity compared more established such procalcitonin, thus requiring multimodal integration accurate diagnosis. The use in emergency intensive care settings represents opportunity improve critical patient management, particularly when combined markers tools. However, further are needed define universal cut-off confirm validity different contexts pathological scenarios.

Language: Английский

Biomarkers in sepsis DOI
Juhi Saxena,

Sarvjeet Das,

Anshu Kumar

et al.

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 562, P. 119891 - 119891

Published: July 26, 2024

Language: Английский

Citations

11
The Role of Monocyte Distribution Width (MDW) in the Prediction of Death in Adult Patients with Sepsis DOI Creative Commons
Dimitrios Theodoridis, Angeliki Tsifi, Emmanouil Magiorkinis

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 427 - 427

Published: Feb. 15, 2025

Sepsis is a life-threatening condition; it major cause of hospital mortality worldwide and constitutes global health problem. This research investigates the use MDW as predictor for septic patients. was double-center prospective cohort study adult Septic patients were identified categorized into two categories: those who improved died. Blood drawn from three times, on first, third, fifth day their admission to hospital. evaluated biomarker predict patient outcome. In addition, existing inflammatory markers recorded in all The able patient's average found be significantly higher died records. For example, an value 28.4 first shown best cut-off determining fatal outcomes; receiver operating characteristic (ROC) analysis revealed area under curve 0.71 (95% Confidence Interval-CI: 0.57-0.84) with sensitivity 64.7% specificity 88.2%. conclusion, MDW, addition being marker that can quickly detect sepsis more effectively than other biomarkers, which proven by numerous studies, could also used indicator work attempt direction.

Language: Английский

Citations

0
Diagnostic Performance of Monocyte Distribution Width for the Detection of Sepsis: A Systematic Review and Meta-Analysis DOI Creative Commons
Gregory Eisinger,

QUINN HOSLER,

Elliott D. Crouser

et al.

Journal of the American College of Emergency Physicians Open, Journal Year: 2025, Volume and Issue: 6(2), P. 100073 - 100073

Published: Feb. 21, 2025

To aggregate literature on the diagnostic performance of monocyte distribution width (MDW) for sepsis detection among adults in emergency department and inpatient settings. We searched MEDLINE, EMBASE, SCOPUS, Cochrane databases studies evaluating MDW diagnosis hospital setting through October 19, 2024. Two authors (G.E. Q.H.) independently performed eligibility assessment, data extraction, risk bias assessment. evaluated sepsis-2 sepsis-3 separately applied separate thresholds depending anticoagulant used blood collection. Data were pooled using a random-effects model. multiple sensitivity analyses to evaluate stability our findings. Twenty-five observational comprising 39,041 patients included. The area under summary receiver operating curve (AUC) was 0.82 (95% CI, 0.78-0.85) both sepsis-3. Sensitivity specificity 0.79 0.74-0.83) 0.7 0.61-0.78) 0.83 0.78-0.88) 0.64 0.55-0.71) threshold-independent weighted-average AUC 0.76 (SD, 0.1) 0.77 0.07) negative predictive value 94% 96% observed similar across all analyses. assessed overall quality evidence be low. performs similarly other biomarkers such as procalcitonin sepsis, with unique advantage rapid availability part routine testing.

Language: Английский

Citations

0
The Need for Standardized Guidelines for the Use of Monocyte Distribution Width (MDW) in the Early Diagnosis of Sepsis DOI Open Access
Andrea Piccioni,

Fabio Spagnuolo,

Silvia Baroni

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 15(1), P. 5 - 5

Published: Dec. 27, 2024

Sepsis is a complex and potentially life-threatening syndrome characterized by an abnormal immune response to infection, which can lead organ dysfunction, septic shock, death. Early diagnosis crucial improving prognosis reducing hospital management costs. This narrative review aims summarize evaluate the current literature on role of monocyte distribution width (MDW) as diagnostic biomarker for sepsis, highlighting its advantages, limitations, potential clinical applications. MDW measures volumetric monocytes, reflecting monocytic anisocytosis, detected using advanced hematological analyzers. In 2019, it was approved FDA sepsis due ability identify systemic inflammatory at early stage. Thirty-one studies analyzed us have shown that increased value associated with higher risk combination parameters (such qSOFA) other biomarkers (CRP, PCT) enhance sensitivity stratification capacity. Despite high sensitivity, has lower specificity compared more established such procalcitonin, thus requiring multimodal integration accurate diagnosis. The use in emergency intensive care settings represents opportunity improve critical patient management, particularly when combined markers tools. However, further are needed define universal cut-off confirm validity different contexts pathological scenarios.

Language: Английский

Citations

0