p-Toluene-sulfonic Acid-catalyzed One-pot, Three-component Synthesis of 4-(4-(Piperidin-1-yl)phenyl)-2-Thioxo-1,2,3,4Tetrahydro-5H-Chromeno[4,3-d]Pyrimidin-5-One DOI Open Access
Hamdy Khamees Thabet, Mustafa Turki Ubeid,

Mohamed Yousef Abu Shuheil

et al.

Oriental Journal Of Chemistry, Journal Year: 2022, Volume and Issue: 38(2), P. 406 - 409

Published: April 29, 2022

Here we communicate a method for the synthesis of 4-(4-(piperidin-1-yl)phenyl)-2-thioxo-1,2,3,4-tetrahydro-5H-chromeno[4,3-d]pyrimidin-5-one in one step. The compound was prepared by reacting 4-hydroxy-coumarin, 4-piperidinobenzaldehye, and thiourea catalytic quantity p-toluenesulfonic acid. novelty checked Sci-finder. analyzed NMR spectroscopy (1H, 13C), mass spectrometry. computational studies indicate that synthesized possesses suitable physicochemical properties, drug-likeliness features, good oral bioavailability.

Language: Английский

p-Toluenesulfonic acid-promoted organic transformations for the generation of molecular complexity DOI
Sanchari Pal, Debjit Das, Sabyasachi Bhunia

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(8), P. 1527 - 1579

Published: Jan. 1, 2024

Since the beginning of this century,

Language: Английский

Citations

4
Chemistry of Quinoline Based Heterocycle Scaffolds: A Comprehensive Review DOI

Rajni Rajni,

Versha,

Lakhwinder Singh

et al.

ChemistrySelect, Journal Year: 2022, Volume and Issue: 7(46)

Published: Dec. 12, 2022

Abstract Quinoline is a significant scaffold among heterocyclic compounds and can be used as key building block for the development of novel medications. its derivatives are recognised biologically active substances with number pharmacological properties. Nowadays, quinoline‐ based heterocycle scaffolds have achieved prominent position in medicinal chemistry due to their biological The discovery creation cutting‐edge medications treat variety diseases an example usefulness these compounds. current study outlines range methods available create different quinolone‐based advantageous therapeutic applications using literature that has been published up 2022.

Language: Английский

Citations

8
Synthesis and Biological Activity of Chromeno[3,2-c]Pyridines DOI Creative Commons
Анна В. Листратова, Р. С. Борисов,

Nikolay Yu. Polovkov

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(21), P. 4997 - 4997

Published: Oct. 22, 2024

The review summarizes all synthetic methodologies for the preparation of chromeno[3,2-c]pyridines and chromeno[3,2-c]quinolines. proposed approaches are systemized based on ways construction heterocyclic system. presence these compounds in nature their bioactivity also discussed. Natural products with an annelated chromeno[3,2-c]pyridine fragment well-known a number alkaloids derived from this system as key core have been recently isolated. These demonstrate antimicrobial, antivirus, cytotoxic activities, making structural motifs promising medicinal chemistry.

Language: Английский

Citations

0
p-Toluene-sulfonic Acid-catalyzed One-pot, Three-component Synthesis of 4-(4-(Piperidin-1-yl)phenyl)-2-Thioxo-1,2,3,4Tetrahydro-5H-Chromeno[4,3-d]Pyrimidin-5-One DOI Open Access
Hamdy Khamees Thabet, Mustafa Turki Ubeid,

Mohamed Yousef Abu Shuheil

et al.

Oriental Journal Of Chemistry, Journal Year: 2022, Volume and Issue: 38(2), P. 406 - 409

Published: April 29, 2022

Here we communicate a method for the synthesis of 4-(4-(piperidin-1-yl)phenyl)-2-thioxo-1,2,3,4-tetrahydro-5H-chromeno[4,3-d]pyrimidin-5-one in one step. The compound was prepared by reacting 4-hydroxy-coumarin, 4-piperidinobenzaldehye, and thiourea catalytic quantity p-toluenesulfonic acid. novelty checked Sci-finder. analyzed NMR spectroscopy (1H, 13C), mass spectrometry. computational studies indicate that synthesized possesses suitable physicochemical properties, drug-likeliness features, good oral bioavailability.

Language: Английский

Citations

0