Biomedicines, Journal Year: 2024, Volume and Issue: 13(1), P. 75 - 75

Published: Dec. 31, 2024

Background/Objectives: Transient Receptor Potential Melastatin 8 (TRPM8) is a non-selective, Ca2+-permeable cation channel involved in thermoregulation and other physiological processes, such as basal tear secretion, cell differentiation, insulin homeostasis. The activation deactivation of TRPM8 occur through genetic modifications, interactions, signaling cascades. Recent evidence suggests significant role the hypothalamus amygdala related to pain sensation sexual behavior. Notably, has been implicated neuropathic pain, migraines, neurodegenerative diseases Parkinson’s disease. Our laboratory identified testosterone high-affinity ligand TRPM8. deficiency appears influence behavioral traits mice, like increased aggression deficits satiety. Here, we aim explore pathways altered brain tissues TRPM8-deficient mice using expression methylation profiles messenger RNA (mRNA) long non-coding (lncRNA). Specifically, focused on regions integral hormonal control, including olfactory bulb, hypothalamus, amygdala, insula. Methods: was isolated purified for microarray analysis collected from male wild-type knockout mice. Results: We various differentially expressed genes tied multiple pathways. Among them, androgen–estrogen receptor (AR-ER) pathway, steroidogenesis reward cocaine pathway are particularly worth noting. Conclusions: These results should bridge existing gaps knowledge regarding inform potential targets future studies elucidate its behavior changes pathology associated with activity.

Language: Английский