Moringa oleifera: A comprehensive review on pharmacology, phytochemistry, and clinical applications DOI Open Access

Shital Darekar,

Ashwini A. Patil,

Sunita Bathe

et al.

International Journal of Pharmaceutical Chemistry and Analysis, Journal Year: 2023, Volume and Issue: 10(4), P. 243 - 252

Published: Dec. 15, 2023

commonly referred to as the "tree of life" or "miracle tree," holds wide spectrum medicinal and non-medicinal benefits, so it is valuable herbal plant. has been traditionally use for treating various disease conditions such wounds, pain, ulcers, liver disease, heart cancer, inflammation. Pharmacological studies have substantiated hepatoprotective, cardioprotective, anti-inflammatory potential inherent in extracts derived from parts Notably, bioactive constituents identified every part plant, with over one hundred compounds characterized date. The plant rich alkaloids, flavonoids, anthraquinones, vitamins, glycosides, terpenes, among other things. Furthermore, discovery novel chemicals niazimin A&B muramoside A&B, revealed potent anticancer, antihypertensive, antioxidant, nutritional qualities. This current review underscores traditional remarkable advantages Moringa, delving into its pharmacological characteristics, phytopharmaceutical formulations, clinical examinations, toxicity profile, applications. Additionally, aims shed light on plant's commercial applications intention fostering further research. Despite this comprehensive exploration, acknowledges that many conventional uses Moringa still lack scientific investigation. Consequently, study advocates research unravel mechanistic pathways, aiming pinpoint isolate active synergistic accountable properties.

Language: Английский

In-silico screening of bioactive compounds of Moringa oleifera as potential inhibitors targeting HIF-1α/VEGF/GLUT-1 pathway against Breast Cancer DOI

Neha Masarkar,

Maynak Pal, Mithun Roy

et al.

Journal of Complementary and Integrative Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract Objectives Breast cancer is among the most heterogeneous and aggressive diseases a foremost cause of death in women globally. Hypoxic activation HIF-1α breast cancers triggers transcription battery genes encoding proteins that facilitate tumor growth metastasis correlated with poor prognosis. Based on reported cytotoxic anti-cancer properties Moringa oleifera ( Mo ), this study explores inhibitory effect bioactive compounds from M. target HIF-1α, VEGF, GLUT-1 silico . Methods The X-ray crystallographic structures GLUT1 were sourced Protein Data Bank (PDB) docked 70 3D PubChem using AutoDock Vina, binding modes analyzed Discovery Studio. Five highest energies selected further drug-likeness, oral bioavailability, ADME, toxicity profiles SwissADME, ADMETSaR, ADMETlab 3.0 web server. Results Out screened compounds, top five best identified namely Apigenin, Ellagic Acid, Isorhamnetin, Luteolin, Myricetin each receptor. Molecular docking results indicated ligands interact strongly receptors through hydrogen bonds hydrophobic interactions. These showed favorable drug-like pharmacokinetic properties, possessed no substantial toxicity, fairly bioavailable. Conclusions suggested possess strong potential developing putative lead targeting are safe natural plant-based drugs against cancer.

Language: Английский

Citations

2
Phytochemical Assessment and Potential Pharmacological Activity of Moringa Oleifera Extract DOI

Aziza Alisherovna Turakhanova,

Fatima Khamzatovna Bidzhieva,

Daria Vasilyevna Solovyeva

et al.

Pharmacophore, Journal Year: 2024, Volume and Issue: 15(4), P. 46 - 53

Published: Jan. 1, 2024

Language: Английский

Citations

0
Moringa oleifera: A comprehensive review on pharmacology, phytochemistry, and clinical applications DOI Open Access

Shital Darekar,

Ashwini A. Patil,

Sunita Bathe

et al.

International Journal of Pharmaceutical Chemistry and Analysis, Journal Year: 2023, Volume and Issue: 10(4), P. 243 - 252

Published: Dec. 15, 2023

commonly referred to as the "tree of life" or "miracle tree," holds wide spectrum medicinal and non-medicinal benefits, so it is valuable herbal plant. has been traditionally use for treating various disease conditions such wounds, pain, ulcers, liver disease, heart cancer, inflammation. Pharmacological studies have substantiated hepatoprotective, cardioprotective, anti-inflammatory potential inherent in extracts derived from parts Notably, bioactive constituents identified every part plant, with over one hundred compounds characterized date. The plant rich alkaloids, flavonoids, anthraquinones, vitamins, glycosides, terpenes, among other things. Furthermore, discovery novel chemicals niazimin A&B muramoside A&B, revealed potent anticancer, antihypertensive, antioxidant, nutritional qualities. This current review underscores traditional remarkable advantages Moringa, delving into its pharmacological characteristics, phytopharmaceutical formulations, clinical examinations, toxicity profile, applications. Additionally, aims shed light on plant's commercial applications intention fostering further research. Despite this comprehensive exploration, acknowledges that many conventional uses Moringa still lack scientific investigation. Consequently, study advocates research unravel mechanistic pathways, aiming pinpoint isolate active synergistic accountable properties.

Language: Английский

Citations

0