Diabetes Mellitus and Cognitive Decline: A Systematic Review Exploring the Link to Dementia and Neurodegenerative Diseases DOI Open Access
Abdul Khaliq,

Aroon Kumar,

Mahnoor Khan

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

This systematic review explores the association between diabetes mellitus (DM) and cognitive decline, with a particular focus on neurodegenerative diseases such as dementia Alzheimer's disease (AD). A comprehensive search strategy, conducted in accordance Preferred Reporting Items for Systematic reviews Meta-Analyses (PRISMA) guidelines, identified selected nine meta-analyses of high relevance methodological rigor. These studies encompassed diverse populations, including stroke survivors, apolipoprotein E (APOE) ɛ4 carriers, individuals metabolic syndrome, examined both interventions, glucose-lowering therapies, risk factors, hypoglycemia poor glycemic control. Key findings indicate that is significant factor strong associations observed impaired glucose metabolism elevated tau biomarkers. Glucose-lowering particularly sodium-glucose cotransporter-2 (SGLT-2) inhibitors metformin, demonstrated potential neuroprotective effects, reducing impairment. However, heterogeneity among variability study designs highlight need further high-quality research to validate these elucidate underlying mechanisms. underscores importance integrating health into management highlights targeted interventions mitigate burden associated diabetes.

Language: Английский

Diabetes Mellitus and Cognitive Decline: A Systematic Review Exploring the Link to Dementia and Neurodegenerative Diseases DOI Open Access
Abdul Khaliq,

Aroon Kumar,

Mahnoor Khan

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

This systematic review explores the association between diabetes mellitus (DM) and cognitive decline, with a particular focus on neurodegenerative diseases such as dementia Alzheimer's disease (AD). A comprehensive search strategy, conducted in accordance Preferred Reporting Items for Systematic reviews Meta-Analyses (PRISMA) guidelines, identified selected nine meta-analyses of high relevance methodological rigor. These studies encompassed diverse populations, including stroke survivors, apolipoprotein E (APOE) ɛ4 carriers, individuals metabolic syndrome, examined both interventions, glucose-lowering therapies, risk factors, hypoglycemia poor glycemic control. Key findings indicate that is significant factor strong associations observed impaired glucose metabolism elevated tau biomarkers. Glucose-lowering particularly sodium-glucose cotransporter-2 (SGLT-2) inhibitors metformin, demonstrated potential neuroprotective effects, reducing impairment. However, heterogeneity among variability study designs highlight need further high-quality research to validate these elucidate underlying mechanisms. underscores importance integrating health into management highlights targeted interventions mitigate burden associated diabetes.

Language: Английский

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