Nanoengineering Solutions for Cancer Therapy: Bridging the Gap between Clinical Practice and Translational Research DOI Open Access
Pankaj Garg, Siddhika Pareek, Prakash Kulkarni

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3466 - 3466

Published: June 13, 2024

Nanoengineering has emerged as a progressive method in cancer treatment, offering precise and targeted delivery of therapeutic agents while concurrently reducing overall toxicity. This scholarly article delves into the innovative strategies advancements nanoengineering that bridge gap between clinical practice research field treatment. Various nanoengineered platforms such nanoparticles, liposomes, dendrimers are scrutinized for their capacity to encapsulate drugs, augment drug efficacy, enhance pharmacokinetics. Moreover, investigates breakthroughs drive progression enhancement remedies, encompassing identification biomarkers, establishment preclinical models, advancement biomaterials, all which imperative translating laboratory findings practical medical interventions. Furthermore, integration nanotechnology with imaging modalities, amplify detection, treatment monitoring, response assessment, is thoroughly examined. Finally, obstacles prospective directions nanoengineering, including regulatory challenges issues related scalability, underscores significance fostering collaboration among various entities order efficiently translate interventions enhanced therapies patient management.

Language: Английский

Harnessing the Power of Polyphenols: A New Frontier in Disease Prevention and Therapy DOI Creative Commons
Mohamed El Oirdi

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 692 - 692

Published: May 27, 2024

There are a wide variety of phytochemicals collectively known as polyphenols. Their structural diversity results in broad range characteristics and biological effects. Polyphenols can be found foods drinks, including fruits, cereals, tea, coffee. Studies both vitro vivo, well clinical trials, have shown that they possess potent antioxidant activities, numerous therapeutic effects, health advantages. Dietary polyphenols demonstrated the potential to prevent many problems, obesity, atherosclerosis, high blood sugar, diabetes, hypertension, cancer, neurological diseases. In this paper, protective effects mechanisms behind them investigated detail, citing most recent available literature. This review aims provide comprehensive overview current knowledge on role preventing managing chronic The cited publications derived from vitro, human-based studies trials. A more complete understanding these naturally occurring metabolites will pave way for development novel polyphenol-rich diet drug programs. This, turn, provides further evidence their benefits.

Language: Английский

Citations

19
LncRNA FAM30A Suppresses Proliferation and Metastasis of Colorectal Carcinoma by Blocking the JAK–STAT Signalling DOI Creative Commons
Jin Liu, Shuangyin Han, Yuanbo Cui

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(4)

Published: Feb. 1, 2025

ABSTRACT Colorectal carcinoma (CRC) poses a serious risk to global human health. Long non‐coding RNAs (LncRNAs) play an important role in the pathogenesis of CRC. There is scarcity data about newly identified lncRNA, FAM30A. Our major objective investigate FAM30A process Gene expression and correlated clinical information were retrieved downloaded from public databases identify differentially expressed genes linked The was samples CRC cell lines using via Quantitative Real‐time Polymerase Chain Reaction (qPCR) assay also. survival significance determined R package “survival.” Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis performed FAM30A‐related signalling pathway. levels proteins by western blot assay. effect on biological behaviours evaluated function experiments. down‐regulated based database. had lower lines. Low positively related poor prognosis patients. After overexpressed, proliferation, invasion, migration abilities cells decreased, rate apoptosis increased. Furthermore, overexpression could block JAK–STAT signalling. suppresses proliferative, invasive, migratory through blocking Thus, it can be novel biomarker prognosis.

Language: Английский

Citations

1
The impact of the ATP-binding cassette (ABC) transporter family on multidrug resistance in head and neck tumors DOI
Wei Zhang,

Zhengxin Zhu,

Yuehui Liu

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 21, 2025

Language: Английский

Citations

0
Innovative Nanomedicine Delivery: Targeting Tumor Microenvironment to Defeat Drug Resistance DOI Creative Commons
Wenjun Meng, Li Huang,

Jia‐Min Guo

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1549 - 1549

Published: Dec. 3, 2024

Nanodrug delivery systems have revolutionized tumor therapy like never before. By overcoming the complexity of microenvironment (TME) and bypassing drug resistance mechanisms, nanotechnology has shown great potential to improve efficacy reduce toxic side effects. This review examines impact TME on recent advances in nanomedicine overcome this challenge. Characteristics such as hypoxia, acidity, high interstitial pressure significantly effectiveness chemotherapy radiotherapy, leading increased cells. Then, summarizes innovative nanocarrier designs for these microenvironmental features, including hypoxia-sensitive nanoparticles, pH-responsive carriers, multifunctional nanosystems that enable targeted release improved penetration accumulation tumors. combining with therapeutic strategies, offers a novel perspective by focusing design nanocarriers interact TME, dimension often overlooked similar reviews. We highlight dual role modulation, emphasize their resistance, look at future research directions.

Language: Английский

Citations

3
A first-in-class non-cytotoxic nanocarrier based on a recombinant human ferritin boosts targeted therapy, chemotherapy and immunotherapy DOI Creative Commons
Giada Tisci, Lenka Rajsiglová, Sandra Bibbò

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142843 - 142843

Published: April 1, 2025

Language: Английский

Citations

0
Nanoengineering Solutions for Cancer Therapy: Bridging the Gap between Clinical Practice and Translational Research DOI Open Access
Pankaj Garg, Siddhika Pareek, Prakash Kulkarni

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(12), P. 3466 - 3466

Published: June 13, 2024

Nanoengineering has emerged as a progressive method in cancer treatment, offering precise and targeted delivery of therapeutic agents while concurrently reducing overall toxicity. This scholarly article delves into the innovative strategies advancements nanoengineering that bridge gap between clinical practice research field treatment. Various nanoengineered platforms such nanoparticles, liposomes, dendrimers are scrutinized for their capacity to encapsulate drugs, augment drug efficacy, enhance pharmacokinetics. Moreover, investigates breakthroughs drive progression enhancement remedies, encompassing identification biomarkers, establishment preclinical models, advancement biomaterials, all which imperative translating laboratory findings practical medical interventions. Furthermore, integration nanotechnology with imaging modalities, amplify detection, treatment monitoring, response assessment, is thoroughly examined. Finally, obstacles prospective directions nanoengineering, including regulatory challenges issues related scalability, underscores significance fostering collaboration among various entities order efficiently translate interventions enhanced therapies patient management.

Language: Английский

Citations

2