Local Application of Minimally Manipulated Autologous Stromal Vascular Fraction (SVF) Reduces Inflammation and Improves Bilio-Biliary Anastomosis Integrity DOI Open Access
Ilya Klabukov, G A Shatveryan, Н Н Багмет

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 222 - 222

Published: Dec. 30, 2024

Bilio-biliary anastomosis (BBA) is a critical surgical procedure that performed with the objective of restoring bile duct continuity. This often required in cases where there has been an injury to extrahepatic ducts or during liver transplantation. Despite advances techniques, healing BBA remains significant challenge, complications such as stricture formation and leakage affecting patient outcomes. The stromal vascular fraction (SVF), heterogeneous cell population derived from adipose tissue, demonstrated promise regenerative medicine due its rich content stem cells, endothelial progenitor growth factors. this study was evaluate potential locally administered autologous SVF enhance BBAs. on swine model (female Landrace pigs). Six were divided into two groups: treatment group (

Language: Английский

Diversity and heterogeneity in human pancreaticobiliary maljunction revealed by single-cell RNA sequencing DOI

Huimin Mao,

Wanliang Guo, Siyu Shi

et al.

Pediatric Surgery International, Journal Year: 2025, Volume and Issue: 41(1)

Published: March 21, 2025

Language: Английский

Citations

0
Liver injury in sepsis: manifestations, mechanisms and emerging therapeutic strategies DOI Creative Commons

Xinqi Xu,

Tingyu Yang, Jie An

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 28, 2025

Sepsis is defined as a condition related to infection that manifests with multiorgan dysfunction, representing life-threatening state. Consequently, severe complications frequently occur, liver injury being one of the most prevalent serious sepsis. Liver dysfunction during sepsis serves an independent predictor mortality. This review provides comprehensive overview current research on sepsis-induced (SILI), encompassing clinical manifestations, diagnostic criteria, pathogenesis and therapeutic strategies associated this condition. SILI may manifest hypoxic hepatitis due ischemia shock, cholestasis resulting from abnormal bile metabolism, or duct sclerosis. The pathophysiology involves intricate interactions among inflammatory response, oxidative stress, cell death. All these factors complicate treatment represent potential targets for intervention. Furthermore, addresses limitations inherent in conventional therapies currently employed managing emphasizes novel targeted aimed at addressing fundamental mechanisms underlying

Language: Английский

Citations

0
Dietary patterns, genetic predisposition, and risk of cholelithiasis: a large-scale prospective cohort study DOI Creative Commons

Kecheng Jin,

Ningning Mi,

Wangping He

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Sept. 27, 2024

Background Limited epidemiological evidence exists concerning the impact of healthy dietary patterns on reducing risk cholelithiasis. We aimed to examine association seven established with subsequent cholelithiasis and whether this was modified by genetic risk. Methods conducted a prospective cohort study from UK Biobank, including 155,323 participants initially free cholecystectomy. Dietary were assessed using validated food frequency questionnaire (Oxford WebQ), covering Mediterranean Diet Score (MED), alternate Score(aMED), overall Plant-based Index (PDI), (hPDI), unhealthy (uPDI), Healthy Eating 2015 (HEI-2015) EAT-lancet Score. Genetic quantified stratified polygenic score (PRS) incorporating 13 known cholelithiasis-associated loci. Cox proportional hazards regression employed estimate between patterns, PRS, incidence, adjusting for potential confounders. Results During median follow-up 13.3 years, 5,056 cases identified. After confounders, adherence aMED HEI-2015 reduced 10% (HR: 0.90; 95%CI: 0.83–0.98) 11% 0.89; 0.82–0.96), respectively. A significant decrease in observed across PRS quintiles, low associated 16% 0.84; 0.77–0.92). Participants both high scores had lowest risk, an HR 0.76 (95%CI: 0.64–0.91) 0.73 0.61–0.88) HEI-2015. Conclusion Higher might significantly cholelithiasis, irrespective Our results highlighted diet intervention prevention general population.

Language: Английский

Citations

1
Local Application of Minimally Manipulated Autologous Stromal Vascular Fraction (SVF) Reduces Inflammation and Improves Bilio-Biliary Anastomosis Integrity DOI Open Access
Ilya Klabukov, G A Shatveryan, Н Н Багмет

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 222 - 222

Published: Dec. 30, 2024

Bilio-biliary anastomosis (BBA) is a critical surgical procedure that performed with the objective of restoring bile duct continuity. This often required in cases where there has been an injury to extrahepatic ducts or during liver transplantation. Despite advances techniques, healing BBA remains significant challenge, complications such as stricture formation and leakage affecting patient outcomes. The stromal vascular fraction (SVF), heterogeneous cell population derived from adipose tissue, demonstrated promise regenerative medicine due its rich content stem cells, endothelial progenitor growth factors. this study was evaluate potential locally administered autologous SVF enhance BBAs. on swine model (female Landrace pigs). Six were divided into two groups: treatment group (

Language: Английский

Citations

0