Published: Jan. 1, 2024
Language: Английский
Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42739 - e42739
Published: Feb. 1, 2025
This review explores the synergistic potential of natural products and nanotechnology for viral infections, highlighting key antiviral, immunomodulatory, antioxidant properties to combat pandemics caused by highly infectious viruses. These often result in severe public health crises, particularly affecting vulnerable populations due respiratory complications increased mortality rates. A cytokine storm is initiated when an overload pro-inflammatory cytokines chemokines released, leading a systemic inflammatory response. Viral mutations limited availability effective drugs, vaccines, therapies contribute continuous transmission virus. The coronavirus disease-19 (COVID-19) pandemic has sparked renewed interest product-derived antivirals. efficacy traditional medicines against infections examined. Their anti-inflammatory, are highlighted. discusses how enhances herbal combating infections.
Language: Английский
Citations
1
Annals of Clinical Microbiology and Antimicrobials, Journal Year: 2025, Volume and Issue: 24(1)
Published: April 20, 2025
Abstract Background Long COVID is a complex, heterogeneous syndrome affecting over four hundred million people globally. There are few recommendations, and no formal training exists for medical professionals to assist with clinical evaluation management of patients COVID. More research into the pathology, cellular, molecular mechanisms COVID, treatments needed. The goal this work disseminate essential information about recommendations definition, diagnosis, treatment, social issues physicians, researchers, policy makers address escalating global health crisis. Methods A 3-round modified Delphi consensus methodology was distributed internationally 179 healthcare professionals, persons lived experience in 28 countries. Statements were combined specific areas: research, society. Results survey resulted 187 comprehensive statements reaching strongest areas being diagnosis assessment, general research. We establish conditions different subgroups within umbrella. Clear reached that impacts COVID-19 infection on children should be priority, additionally need determine effects societies economies. it affects nervous system other organs not likely observed initial symptoms. note, biomarkers critically needed these issues. Conclusions This forms guidance spectrum as disease reinforces translational large-scale treatment trials protocols.
Language: Английский
Citations
0
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Journal Year: 2025, Volume and Issue: 21(2), P. 112 - 120
Published: April 1, 2025
Background. Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has led to widespread illness and global health challenges. While phase of infection been extensively studied, long-term effects, particularly in individuals who have recovered, remain unclear. Post-acute complications SARS-CoV-2 involves prolonged symptoms systemic disorders, including persistent inflammation, endothelial dysfunction, immune dysregulation, which often last for months. Among key factors contributing these conditions, there are pro-inflammatory cytokines, growth involved angiogenesis, hypoxia-inducible stress-related proteins, play a significant role tissue repair response modulation. The research aimed evaluate degree determine levels pro-angiogenic factors, сellular hypoxia marker HIF-1α, heat shock such as HSP60 HSP70, plasma healthy donors recovered from COVID-19, with particular focus on relationship between biomarkers anti-SARS-CoV-2 IgG titers. Materials methods. This ages 25 45 years, had COVID-19 at least 3 6 months prior beginning study. All patients were divided into groups based their inflammatory TNF-α, transcription factor NF-κB, angiogenic VEGF, PDGF FGF-2, hypoxic proteins measured enzyme-linked immunosorbent assay. Group differences analyzed using ANOVA Tukey’s test or Kruskal-Wallis Dunn’s test, presenting results median interquartile range, significance p ≤ 0.05. Results. study found parameters among donor varying There was an increase markers, TNF-α higher PDGF, FGF-2 showed distinct patterns, VEGF generally reduced, except group titers 95 ± 5 125 10 Index (S/C), where they significantly increased. notably 175 (S/C). HIF-1α also increased 75 (S/C) compared those without IgG. In contrast, HSP70 reduced all reference group, could indicate possible abnormalities mechanisms stress after COVID-19. Conclusions. Our suggest that activation, angiogenesis-related pathways crucial pathogenesis post-COVID-19 complications, underscoring need therapeutic strategies address chronic impaired recovery.
Language: Английский
Citations
0
Seminars in Thrombosis and Hemostasis, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 30, 2024
Abstract Long coronavirus disease 2019 (COVID-19)—a postacute consequence of severe acute respiratory syndrome 2 infection—manifests with a broad spectrum relapsing and remitting or persistent symptoms as well varied levels organ damage, which may be asymptomatic present events such heart attacks strokes recurrent infections, hinting at complex underlying pathogenic mechanisms. Central to these is vascular dysfunction rooted in thrombotic endothelialitis. We review the scientific evidence that widespread endothelial (ED) leads chronic symptomatology. briefly examine molecular pathways contributing pathology provide detailed analysis how cellular processes underpin clinical picture. Noninvasive diagnostic techniques, flow-mediated dilation peripheral arterial tonometry, are evaluated for their utility identifying ED. then explore mechanistic, cellular-targeted therapeutic interventions potential treating Overall, we emphasize critical role health managing COVID highlight need early intervention prevent long-term dysfunction.
Language: Английский
Citations
3
Health Promotion International, Journal Year: 2024, Volume and Issue: 39(5)
Published: Aug. 28, 2024
Although the World Health Organization's (WHO's) framework on social and structural determinants of health inequities (SSDHHI) has done much to raise awareness these determinants, it does not go far enough in considerations politics power. The become more de-politicized since its publication, with definition shifting toward downstream individualized factors. In meantime, new research fields legal, commercial political have emerged; however, integrated adequately into broader SSDHHI frameworks. To address challenges, we argue for a re-politicization an expansion WHO's by including agents who power over shaping ways they use shape determinants. We also provide detailed conceptualization facilitate research. propose guideline evaluating studies according extent which point upstream versus incorporate then this encourage associations among agents, mechanisms power, determinants; how changes affect dynamics agents; wider focus beyond laws policies, such as broad economic sociopolitical systems. urge researchers consider societal institutional forces their respect SSDHHI. Research based can be used evidence advocacy build just systems that fundamental human right healthy life.
Language: Английский
Citations
2
Published: Jan. 1, 2024
Language: Английский
Citations
0