The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications DOI Creative Commons
Bence Kontra, Zoltán Mucsi, Janez Ilaš

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design mode application have made them useful tools studying dynamic biological processes in vitro vivo. Recently, there has been growing body data investigating potential development drug delivery systems. Of various PPG scaffolds use, quinoline photocages history about 20 years. The structure-property relationships PPGs, as well alternative multibranch designs based on monomers thoroughly studied both experimentally theoretically. Therefore, PPGs serve representative study development, showing how applications followed chemical optimization or drove design. Since raison d'être lies light-activated performing structural changes materials, it is crucial to understand are selected utilized end-users, who often not chemists themselves. we discuss whether conclusions drawn from family could lead more general insights field whole. As PPG-related still rely heavily limited number scaffolds, worth considering, what be reasons slow uptake novel scaffolds.

Language: Английский

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications DOI Creative Commons
Bence Kontra, Zoltán Mucsi, Janez Ilaš

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design mode application have made them useful tools studying dynamic biological processes in vitro vivo. Recently, there has been growing body data investigating potential development drug delivery systems. Of various PPG scaffolds use, quinoline photocages history about 20 years. The structure-property relationships PPGs, as well alternative multibranch designs based on monomers thoroughly studied both experimentally theoretically. Therefore, PPGs serve representative study development, showing how applications followed chemical optimization or drove design. Since raison d'être lies light-activated performing structural changes materials, it is crucial to understand are selected utilized end-users, who often not chemists themselves. we discuss whether conclusions drawn from family could lead more general insights field whole. As PPG-related still rely heavily limited number scaffolds, worth considering, what be reasons slow uptake novel scaffolds.

Language: Английский

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