Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 159048 - 159048
Published: Dec. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136549 - 136549
Published: Oct. 1, 2024
Language: Английский
Citations
4
Polymer-Plastics Technology and Materials, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23
Published: Dec. 16, 2024
Polymers have become a versatile tool in pharmaceutical chemistry through techniques and new formulation. This review presents an overview of the general topic drug delivery polymers, places particular focus on their specific contributions, discusses significant issues like biocompatibility, controlled release targeted delivery. Unlike previous reviews, it captures recent development biodegradable, smart stimuli-responsive abilities to improve therapy outcomes patient adherence treatments. Furthermore, this work also has enhanced understanding advanced polymer-based systems such as polymeric nanoparticles, bioconjugation strategies natural with examples various therapeutic areas. The stands for itself by expanding discussion regulatory clinical realism difficulties well safety, efficacy, acceptance considerations. In addition, emphasizes role interdisciplinary intersectoral cooperation cross-country collaborations developing polymers-based applications precision medicine. way, provides fresh view both present advancements future possibilities technologies dedicated achievements globally inspire researchers practitioners.
Language: Английский
Citations
4
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: March 19, 2025
Language: Английский
Citations
0
Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100462 - 100462
Published: April 1, 2025
Language: Английский
Citations
0
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: April 25, 2025
Diabetes is a growing global health issue, with millions of people affected by the condition. While insulin therapy vital for managing both Type 1 and 2 diabetes, traditional methods such as subcutaneous injections have notable drawbacks, including pain, discomfort, difficulty in maintaining stable blood sugar levels. To improve delivery, research increasingly focused on use natural polymers-substances derived from plants, animals, microorganisms. These polymers, materials like alginate, chitosan, hyaluronic acid, promising properties biocompatibility, biodegradability, ability to provide controlled, sustained release. By encapsulating it protected degradation released manner that more closely mirrors body's production. Furthermore, development non-invasive delivery methods, oral transdermal systems, gaining momentum, offering potential patient-friendly treatment options. This review discusses role polymers examining their mechanisms, types, current efforts. It also addresses challenges remain advancing these technologies into practical clinical use, aiming efficient, comfortable, effective solutions diabetes management.
Language: Английский
Citations
0
Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104852 - 104852
Published: Aug. 3, 2024
Language: Английский
Citations
3
Advances in polymer science, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1460 - 1460
Published: Nov. 15, 2024
: Thymoquinone (TQ) exhibits diverse biological activities, but its poor solubility and bioavailability limit cancer efficacy, requiring innovative solutions. This study explores the development of an oral delivery system targeting colon based on TQ pectin beads (TQ-PBs) produced through adjustable electrospray technique. hypothesised that adjusting bead diameter technique enables precise control over water absorption erosion rates, thereby achieving a controlled release profile for encapsulated TQ, which enhances targeted to colon.
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Dec. 29, 2024
Diabetes mellitus (DM) prevalence is rising worldwide. Current therapies comprising subcutaneous insulin injections can cause adverse effects such as lipodystrophy, local reactions like redness and swelling, fluid retention, allergic reactions. Nanoparticle carriers for oral are groundbreaking compared to existing methods because they non-invasive treatments, showing operational convenience, controlled release profile, ability simulate the physiological delivery route into bloodstream. These systems improve patient adherence have demonstrated potential lower blood glucose levels in DM. We present a systematic review meta-analysis aimed at compiling relevant data pave way developing innovative nano- microparticles of insulin. Our analysis 85 articles revealed that diminution not proportional administered dosage, which ranged from 1 120 International Units (IU). The indicated 25 IU encapsulated porcine did produce statistically significant outcome (p = 0.93). In contrast, dosage 30 was efficacious eliciting an optimal hypoglycemic effect excipient controls. Parameters high degree encapsulation (~ 90%), particle size (200-400 nm), polydispersity index (0.086-0.3) all associated with levels. parameters were also linear regression analysis. Among excipients employed, chitosan emerged prevalent formulations due its biocompatible biodegradable properties establish stable polymeric matrices. Even though administration promising therapeutic method, it cannot guarantee preclinical safety efficacy yet regulating diabetic conditions.
Language: Английский
Citations
1
Zeitschrift für Physikalische Chemie, Journal Year: 2024, Volume and Issue: 0(0)
Published: June 10, 2024
Abstract The objective of this investigation is to explore how doping chitosan (Chi) with different lanthanide oxides (LnO) such as cerium, neodymium, samarium, europium, gadolinium, dysprosium, and holmium affects its thermodynamic properties. Especially the effect contraction which competition between mass size has been investigated reported. describes a method for calculating various physical properties Chi-LnO composite material based on experimental values refractive index, density, viscosity, ultrasonic velocity concerning LnO doped chitosan. These play crucial roles in understanding behavior characteristics materials. process involves deriving dielectric constant, intermolecular free path length, relaxation time, attenuation, relative association, surface tension, Gibbs energy non-linearity parameters are calculated from value viscosity given data results discussed detailed manner.
Language: Английский
Citations
0