Magnetic DL-methionine grafted to chitosan by EDTA linker nanomaterial: a highly efficient multifunctional organocatalyst for the synthesis of highly substituted imidazole derivatives under green conditions DOI
Mohammad Dohendou, Mohammad G. Dekamin,

Zahra Dehnamaki

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract In this research, a novel protocol for the synthesis of imidazole derivatives with various substitutions has been investigated in presence new and highly effective magnetic decorated DL-methionine amino acid grafted onto chitosan backbone by using EDTA linker (CS − MET@Fe3O4) under green chemistry conditions. The CS MET@Fe3O4 nanocomposite was properly characterized FTIR, EDX, XRD, FESEM, TGA VSM spectroscopic, microscopic, or analytical methods. used as efficient heterogeneous organocatalyst wide range three- four-substituted derivatives, an important pharmaceutical scaffold, through multicomponent reactioins (MCRs) strategy. multifunctional nanocatalyst exhibited high catalytic activity, selectivity, stability to promote reactions benzoin benzyl, different aldehyde ammonim acetate well aromatic aliphatic amine EtOH solvent. Key advantages present are excellent yields, use low loading renewable, bio-based biodegredable chitosan- acid-based nanomaterial, simple procedure preparation nanomaterial imoidazole derivatives. addition, catalyst's properties, including its properties appropriate surface area characteristicscontribute performance. Fuerthermore, can be up six cycles only slight decrease activity.

Language: Английский

Preparation of a new reusable magnetic organocatalyst to synthesis of polyhydroquinoline derivatives as cytotoxic Agents: Synthesis and biological evaluation DOI Creative Commons
Leila Amiri‐Zirtol,

Ali Yargholi,

Leila Emami

et al.

Journal of Saudi Chemical Society, Journal Year: 2024, Volume and Issue: 28(6), P. 101922 - 101922

Published: Aug. 30, 2024

Language: Английский

Citations

4
Highlighting multicomponent reactions as an efficient and facile alternative route in the chemical synthesis of organic-based molecules: a tremendous growth in the past 5 years DOI Creative Commons
Reagan L. Mohlala, Thompho Jason Rashamuse,

E. Mabel Coyanis

et al.

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 18, 2024

Since Strecker’s discovery of multicomponent reactions (MCRs) in 1850, the strategy applying an MCR approach has been use for over a century. Due to their ability quickly develop molecular diversity and structural complexity interest, MCRs are considered efficient organic synthesis. Although such as Ugi, Passerini, Biginelli, Hantzsch widely studied, this review emphasizes significance selective elegantly produce compounds potential medicinal chemistry industrial material science applications, well sustainable methods. During synthesis, provide advantages atom economy, recyclable catalysts, moderate conditions, preventing waste, avoiding solvent use. also reduce number sequential multiple one step.

Language: Английский

Citations

4
A novel Hg2+ ion chemosensor based on dihydro-pyrano imidazole derivatives DOI
Ghodsi Mohammadi Ziarani, Nikoo Shamkhali, Zahra Panahande

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1337, P. 142096 - 142096

Published: March 31, 2025

Language: Английский

Citations

0
A facile and efficient one-pot 3-component reaction (3-CR) method for the synthesis of thiazine-based heterocyclic compounds using zwitterion adduct intermediates DOI
Reagan L. Mohlala,

E. Mabel Coyanis

Physical Sciences Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: May 15, 2024

Abstract Multicomponent reactions (MCRs) are considered a green strategy by generating diversity of scaffolds from less synthetic effort and safe conditions. This work present the synthesis dimethyl 8-(tert-butylamino)-4-oxo-4,6-dihydropyrimido[2,1- b ][1,3]thiazine-6,7-dicarboxylate in low to moderate yields 33–74 % prepared 2-amino-4 H -1,3-thiazin-4-one derivatives containing both an acidic proton suitable nucleophile with alkyl isocyanides DMAD/DEtAD. The portrays facile method under chemical production processes using solvents such as acetone, ethanol, isopropanol, 2-methyl-tetrahydrofuran. chapter shows flexibility zwitterion adduct reaction isocyanide DMAD. is trapped forms fused [6-6] heterocyclic compounds. preparation starting material thiazine was carried out at different condition 0 °C temperatures reflux, while novel ][1,3]thiazine-6,7-dicarboxylates done room temperature without use catalyst.

Language: Английский

Citations

2
Synthesis of Pyrano[2,3‐d]pyrimidine Derivatives Catalyzed by Trimetallic Multi‐walled Carbon Nanotubes under Ultrasound Irradiation Conditions DOI

Nasrin Saberi Harooni,

Hossein Naeimi, Amir Hossein Ghasemi

et al.

ChemistrySelect, Journal Year: 2023, Volume and Issue: 8(48)

Published: Dec. 21, 2023

Abstract This study involves the synthesis of pyrano]2,3‐d[pyrimidine derivatives using multi‐component reactions (MCRs) under ultrasonic, and nanocatalysis conditions. The reaction efficiency was increased time reduced by a prepared catalyst accomplished with sonication synergetic effect. Furthermore, increase in product yield can be due to synergistic property between metals on surface catalyst. found recoverable highly stable ultrasonic use trimetallic multi‐walled carbon nanotubes (MWCNTs) proved effective pyrano[2,3‐d]pyrimidine derivatives. is their active site, economical loading, easy workup, reusability, green Also, synthesized products were achieved excellent yields short times. Different methods utilized characterize nanocatalyst such as; Fourier‐transform infrared spectroscopy (FT‐IR), X‐ray powder diffraction (XRD), field emission scanning electron microscope (FE‐SEM), energy‐dispersive (EDS), thermogravimetric analysis (TGA), hot filtration method. organic compounds identified through analyses melting point, FT‐IR method, hydrogen‐1 nuclear magnetic resonance ( 1 H NMR).

Language: Английский

Citations

5
Methionine-ethylenediaminetetraacetic acid-chitosan magnetic nanocomposite: a multifunctional organocatalyst for green heteroannulation of imidazoles DOI Creative Commons
Mohammad G. Dekamin, Mohammad Dohendou,

Danial Namaki

et al.

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: unknown, P. 100638 - 100638

Published: Dec. 1, 2024

Language: Английский

Citations

0
Magnetic DL-methionine grafted to chitosan by EDTA linker nanomaterial: a highly efficient multifunctional organocatalyst for the synthesis of highly substituted imidazole derivatives under green conditions DOI
Mohammad Dohendou, Mohammad G. Dekamin,

Zahra Dehnamaki

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract In this research, a novel protocol for the synthesis of imidazole derivatives with various substitutions has been investigated in presence new and highly effective magnetic decorated DL-methionine amino acid grafted onto chitosan backbone by using EDTA linker (CS − MET@Fe3O4) under green chemistry conditions. The CS MET@Fe3O4 nanocomposite was properly characterized FTIR, EDX, XRD, FESEM, TGA VSM spectroscopic, microscopic, or analytical methods. used as efficient heterogeneous organocatalyst wide range three- four-substituted derivatives, an important pharmaceutical scaffold, through multicomponent reactioins (MCRs) strategy. multifunctional nanocatalyst exhibited high catalytic activity, selectivity, stability to promote reactions benzoin benzyl, different aldehyde ammonim acetate well aromatic aliphatic amine EtOH solvent. Key advantages present are excellent yields, use low loading renewable, bio-based biodegredable chitosan- acid-based nanomaterial, simple procedure preparation nanomaterial imoidazole derivatives. addition, catalyst's properties, including its properties appropriate surface area characteristicscontribute performance. Fuerthermore, can be up six cycles only slight decrease activity.

Language: Английский

Citations

0