Targeting the UCP1-dependent thermogenesis pathway with CRISPR/Cas9: a new approach to obesity management DOI Creative Commons

Esmail Karami,

Fatemeh Rostamkhani, Mohammad Reza Abdollahi

et al.

Current Research in Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 100295 - 100295

Published: May 1, 2025

Language: Английский

Advancing personalized immunotherapy for melanoma: Integrating immunoinformatics in multi-epitope vaccine development, neoantigen identification via NGS, and immune simulation evaluation DOI
Mohammad Javad Kamali, Mohammad Salehi, Mohsen Karami Fath

et al.

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 188, P. 109885 - 109885

Published: Feb. 25, 2025

Language: Английский

Citations

2
Inflammasomes and Cardiovascular Disease: Linking Inflammation to Cardiovascular Pathophysiology DOI

Mohamed J. Saadh,

Faris Anad Muhammad,

Rafid Jihad Albadr

et al.

Scandinavian Journal of Immunology, Journal Year: 2025, Volume and Issue: 101(4)

Published: April 1, 2025

Cardiovascular diseases (CVDs) remain a leading cause of global mortality, driven by risk factors such as dyslipidemia, hypertension and diabetes. Recent research has highlighted the critical role inflammasomes, particularly NLRP3 inflammasome, in pathogenesis various CVDs, including hypertension, atherosclerosis, myocardial infarction heart failure. Inflammasomes are intracellular protein complexes that activate inflammatory responses through production pro-inflammatory cytokines IL-1β IL-18, contributing to endothelial dysfunction, plaque formation injury. This review provides comprehensive overview structure, activation mechanisms pathways with focus on their involvement cardiovascular pathology. Key include ion fluxes (K+ efflux Ca2+ signalling), endoplasmic reticulum (ER) stress, mitochondrial dysfunction lysosomal destabilisation. The also explores therapeutic potential targeting inflammasomes mitigate inflammation improve outcomes CVDs. Emerging strategies small-molecule inhibitors, biologics RNA-based therapeutics, particular emphasis inhibition. Additionally, integration artificial intelligence (AI) offers promising avenues for identifying novel biomarkers, predicting disease developing personalised treatment strategies. Future directions should understanding interactions between other immune components, well genetic regulators, uncover new targets. By elucidating complex this underscores innovative therapies address inflammation-driven pathology, ultimately improving patient outcomes.

Language: Английский

Citations

0
Targeting the UCP1-dependent thermogenesis pathway with CRISPR/Cas9: a new approach to obesity management DOI Creative Commons

Esmail Karami,

Fatemeh Rostamkhani, Mohammad Reza Abdollahi

et al.

Current Research in Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 100295 - 100295

Published: May 1, 2025

Language: Английский

Citations

0