Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance DOI Creative Commons

Jiaxin Tian,

Tongyu Zhang, Ruidan Zhang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 28, 2025

Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of central nervous system (CNS). The groundbreaking application multi-omics integration technologies has unveiled novel role for lactate: lactylation, unique post-translational modification (PTM) that covalently attaches lactate groups to lysine residues on proteins. This process precisely regulates protein function gene expression, profoundly influencing progression diseases. lactylation is meticulously regulated by variety key enzymes pathways, forming dynamic intricate network. In this review, we summarize involved specifically "Writers," "Erasers," "Readers." Furthermore, systematically categorize observed cell types CNS investigate its multifaceted roles processes, including neurodegenerative diseases, brain tumors, injuries. By consolidating latest research findings field, our review aims highlight significance these discoveries future explore their potential translational applications.

Language: Английский

Lactylation in CNS disorders: mechanisms, cellular function, and disease relevance DOI Creative Commons

Jiaxin Tian,

Tongyu Zhang, Ruidan Zhang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 28, 2025

Lactate, as a metabolic product or energy substrate, participates in various neurological processes within the physiological and pathological frameworks of central nervous system (CNS). The groundbreaking application multi-omics integration technologies has unveiled novel role for lactate: lactylation, unique post-translational modification (PTM) that covalently attaches lactate groups to lysine residues on proteins. This process precisely regulates protein function gene expression, profoundly influencing progression diseases. lactylation is meticulously regulated by variety key enzymes pathways, forming dynamic intricate network. In this review, we summarize involved specifically "Writers," "Erasers," "Readers." Furthermore, systematically categorize observed cell types CNS investigate its multifaceted roles processes, including neurodegenerative diseases, brain tumors, injuries. By consolidating latest research findings field, our review aims highlight significance these discoveries future explore their potential translational applications.

Language: Английский

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