Metabolomic Insights into Smoking-Induced Metabolic Dysfunctions: A Comprehensive Analysis of Lipid and Amino Acid Metabolomes DOI Creative Commons
M. Aslam,

Hajra Iqbal,

Kainat Ilyas

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 96 - 96

Published: Feb. 4, 2025

Cigarette smoking is a leading cause of preventable mortality, largely due to the absence effective, non-invasive biomarkers for early disease detection. Profiling serum metabolomics identify metabolic changes holds potential accelerate detection process and individuals at risk developing smoking-related diseases. This study investigated biochemical metabolomic induced by nicotine exposure, with focus on disruptions in amino acid, lipid, carbohydrate metabolism. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed observe significant lipid acid metabolism, along alterations key pathways. A total 400 smokers 100 non-smokers were included evaluate related insulin resistance, blood profile, inflammation, kidney liver function. The results demonstrated significantly elevated (p < 0.05) levels glycemic markers smokers, including fasting glucose; glycated hemoglobin (HbA1c); inflammatory such as interleukin-6 (IL-6) C-reactive protein (CRP). Smokers also exhibited dyslipidemia, increased cholesterol (154.888 ± 35.565) LDL (117.545 24.138). Impaired function evident, higher AST, ALP, ALT, urea nitrogen, creatinine smokers. 930 metabolites identified, which 343 compared non-smokers. Among these, 116 upregulated, 127 downregulated. Metabolomic pathway analysis revealed eight identified three specific seven unique Through LC-MS/MS, fragments phenylalanine, tryptophan, valine, histidine, carnitine, sphinganine detected. Several lipidomic associated resistance cardiovascular complications observed. Cadmium (Cd) than (1.264 ppb vs. 0.624 ppb) showed strong negative correlation (R2 = 0.8061, p-value 0.015) zinc (Zn), likely Cd displacing Zn proteins causing nephrotoxicity through accumulation. highlights distinct caused that could serve It emphasizes importance identifying systemic indicators health issues, providing new opportunities preventive therapeutic interventions.

Language: Английский

Metabolomic Insights into Smoking-Induced Metabolic Dysfunctions: A Comprehensive Analysis of Lipid and Amino Acid Metabolomes DOI Creative Commons
M. Aslam,

Hajra Iqbal,

Kainat Ilyas

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 96 - 96

Published: Feb. 4, 2025

Cigarette smoking is a leading cause of preventable mortality, largely due to the absence effective, non-invasive biomarkers for early disease detection. Profiling serum metabolomics identify metabolic changes holds potential accelerate detection process and individuals at risk developing smoking-related diseases. This study investigated biochemical metabolomic induced by nicotine exposure, with focus on disruptions in amino acid, lipid, carbohydrate metabolism. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed observe significant lipid acid metabolism, along alterations key pathways. A total 400 smokers 100 non-smokers were included evaluate related insulin resistance, blood profile, inflammation, kidney liver function. The results demonstrated significantly elevated (p < 0.05) levels glycemic markers smokers, including fasting glucose; glycated hemoglobin (HbA1c); inflammatory such as interleukin-6 (IL-6) C-reactive protein (CRP). Smokers also exhibited dyslipidemia, increased cholesterol (154.888 ± 35.565) LDL (117.545 24.138). Impaired function evident, higher AST, ALP, ALT, urea nitrogen, creatinine smokers. 930 metabolites identified, which 343 compared non-smokers. Among these, 116 upregulated, 127 downregulated. Metabolomic pathway analysis revealed eight identified three specific seven unique Through LC-MS/MS, fragments phenylalanine, tryptophan, valine, histidine, carnitine, sphinganine detected. Several lipidomic associated resistance cardiovascular complications observed. Cadmium (Cd) than (1.264 ppb vs. 0.624 ppb) showed strong negative correlation (R2 = 0.8061, p-value 0.015) zinc (Zn), likely Cd displacing Zn proteins causing nephrotoxicity through accumulation. highlights distinct caused that could serve It emphasizes importance identifying systemic indicators health issues, providing new opportunities preventive therapeutic interventions.

Language: Английский

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