Native/modified dextran-based nanogel in delivering drug and management of ocular complications: a review

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Ocular nanogels have emerged as a promising therapeutic approach, and nanotechnology has speed up the growth of pharmaceutical medical technology sectors. The physiological anatomical barriers eye limit use traditional ocular preparations, which leads to low drug bioavailability brief retention period. This presents serious problem for patients, doctors, chemists. Nevertheless, can encapsulate medications within three-dimensional crosslinked polymeric networks provide controlled prolonged delivery by using particular structural layouts unique preparation techniques, improving efficacy patient compliance. Dextran its variants, naturally occurring polysaccharide, drawn lot interest in developing systems applications. Many dextran-based with customized geometries features been fabricated recently, such hydrogels, nanogels, magnetic nanoparticles, nanoemulsions, self-assembled micelles microparticles. review advancement potential treatment various conditions, cataract, conjunctivitis, glaucoma, dry syndrome, age-related macular degeneration, corneal ulcers. Moreover, process development assessing these nanomedicines, emphasizing their safety effectiveness established preclinical, toxicological, clinical assessments, patent updates, elaborated.

Language: Английский

Unlocking the multifaceted potential of lipid-based dispersion as a drug carrier: Targeted applications and stability improvement strategies

Journal of Dispersion Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 33

Published: April 28, 2025

Language: Английский