Projection neurons of the prefrontal cortex, their participation in the formation of various forms of behavior and expression in them of brain-derived neurotrophic factor DOI
U. S. Drozd,

Ya. A. Frik,

A. V. Smagin

et al.

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(9), P. 1316 - 1336

Published: Dec. 13, 2024

The prefrontal cortex (PFC) plays a key role in cognitive plasticity and is involved various processes of higher nervous activity. At the same time, studying underlying forms behavior which PFC neurons participate non-trivial task. associative functions are associated with nature connectivity this structure other areas brain, which, according to recent data, much more complex than previously thought. Thus, it becomes clear that axons projection have many collaterals projecting different targets brain. In review, we highlight latest results using methods for analyzing projections single-cell transcriptomes. Brain-derived neurotrophic factor (BDNF) an important functioning these their targets, but transport neurotrophin by structures where not locally expressed may be especially important. We review mapping such PFC, highlighting Bdnf expression potential pathogenesis mental disorders.

Language: Английский

Neurotrophins and Their Receptors: BDNF’s Role in GABAergic Neurodevelopment and Disease DOI Open Access
Carlos Cano, Natalia Varela-Andrés, Alejandro Cebrián-León

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8312 - 8312

Published: July 30, 2024

Neurotrophins and their receptors are distinctly expressed during brain development play crucial roles in the formation, survival, function of neurons nervous system. Among these molecules, brain-derived neurotrophic factor (BDNF) has garnered significant attention due to its involvement regulating GABAergic system function. In this review, we summarize compare expression patterns neurotrophins both developing adult brains rodents, macaques, humans. Then, focus on implications BDNF from cortex striatum, as presence single nucleotide polymorphisms disruptions levels alter excitatory/inhibitory balance brain. This imbalance different pathogenesis neurodevelopmental diseases like autism spectrum disorder (ASD), Rett syndrome (RTT), schizophrenia (SCZ). Altogether, evidence shows that neurotrophins, especially BDNF, essential for development, maintenance, brain, or signaling common mechanisms pathophysiology diseases.

Language: Английский

Citations

6
BDNF in Ventrolateral Orbitofrontal Cortex to Dorsolateral Striatum Circuit Moderates Alcohol Consumption and Gates Alcohol Habit DOI Creative Commons

Sowmya Gunasekaran,

Jeffrey J. Moffat,

Joshua D. Epstein

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

BDNF plays a crucial role in shaping the structure and function of neurons. signaling dorsolateral striatum (DLS) is part an endogenous pathway that protects against development alcohol use disorder (AUD). Dysregulation levels cortex or dysfunction BDNF/TrkB DLS results escalation drinking compulsive use. The major source prefrontal cortex. We identified small ensemble BDNF-positive neurons ventrolateral orbitofrontal (vlOFC), region involved AUD, extend axonal projections to DLS. speculated vlOFC-to-DLS circuit may play limiting heavy disrupts this protective pathway. found expression reduced vlOFC male but not female mice after long-term cycles binge withdrawal. discovered overexpression vlOFC-to-dorsomedial (DMS) M2 motor cortex-to-DLS reduces sucrose intake preference. habitual behaviors. hypothesized circuitry controls by gating seeking. over-expression systemic administration receptor TrkB agonist, LM22A-4, biases habitually trained towards goal-directed Together, our data suggest gates attenuating

Language: Английский

Citations

0
Corticostriatal Maldevelopment in the R6/2 Mouse Model of Juvenile Huntington Disease DOI Open Access
Carlos Cepeda, Sandra M. Holley,

Joshua Barry

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 18, 2024

There is a growing consensus that brain development in Huntington's disease (HD) abnormal, leading to the idea HD not only neurodegenerative but also neurodevelopmental disorder. Indeed, structural and functional abnormalities have been observed during both humans animal models of HD. However, concurrent study cortical striatal genetic model still lacking. Here we report significant alterations corticostriatal R6/2 mouse juvenile We examined wildtype (WT) mice at postnatal (P) days 7, 14, 21. Morphological examination demonstrated early cellular reminiscent malformations development,

Language: Английский

Citations

0
Prefrontal Cortical Projection Neurons: Involvement in Shaping Different Types of Behaviors, BDNF Expression and Transport DOI
U. S. Drozd,

Ya. A. Frik,

A. V. Smagin

et al.

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(5), P. 2116 - 2133

Published: Sept. 1, 2024

Language: Английский

Citations

0
Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's disease DOI Creative Commons
Carlos Cepeda, Sandra M. Holley,

Joshua Barry

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: unknown, P. 106752 - 106752

Published: Dec. 1, 2024

There is a growing consensus that brain development in Huntington's disease (HD) abnormal, leading to the idea HD not only neurodegenerative but also neurodevelopmental disorder. Indeed, structural and functional abnormalities have been observed during both humans animal models of HD. However, concurrent study cortical striatal genetic model still lacking. Here we report significant alterations corticostriatal R6/2 mouse juvenile We examined wildtype (WT) mice at postnatal (P) days 7, 14, 21. Morphological examination demonstrated early cellular reminiscent malformations development, ex vivo electrophysiological recordings pyramidal neurons (CPNs) age- genotype-dependent changes intrinsic membrane synaptic properties. In general, CPNs had reduced cell capacitance increased input resistance (P7 P14), along with frequency spontaneous excitatory inhibitory events (P7), suggesting delayed maturation. This was confirmed by occurrence GABA

Language: Английский

Citations

0
Projection neurons of the prefrontal cortex, their participation in the formation of various forms of behavior and expression in them of brain-derived neurotrophic factor DOI
U. S. Drozd,

Ya. A. Frik,

A. V. Smagin

et al.

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(9), P. 1316 - 1336

Published: Dec. 13, 2024

The prefrontal cortex (PFC) plays a key role in cognitive plasticity and is involved various processes of higher nervous activity. At the same time, studying underlying forms behavior which PFC neurons participate non-trivial task. associative functions are associated with nature connectivity this structure other areas brain, which, according to recent data, much more complex than previously thought. Thus, it becomes clear that axons projection have many collaterals projecting different targets brain. In review, we highlight latest results using methods for analyzing projections single-cell transcriptomes. Brain-derived neurotrophic factor (BDNF) an important functioning these their targets, but transport neurotrophin by structures where not locally expressed may be especially important. We review mapping such PFC, highlighting Bdnf expression potential pathogenesis mental disorders.

Language: Английский

Citations

0