Reduced Cortical Excitability is Associated with Cognitive Symptoms in Concussed Adolescent Football Players DOI Creative Commons
Kevin Yu, Alex I. Wiesman, Elizabeth M. Davenport

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Abstract Background American tackle football is associated with high rates of concussion, leading to neurophysiological disturbances and debilitating clinical symptoms. Previous investigations the effects concussion have largely ignored aperiodic activity, which a marker cortical excitability. Purpose We examined whether during season school related changes in periodic activity any such are outcomes. Materials Methods Pre- post-season resting-state magnetoencephalography (MEG) data were collected from 91 players over as many four seasons play, for total 278 collections. During these cohort 10 individuals diagnosed concussion. MEG source-imaged, frequency-transformed parameterized, linear mixed models used examine on pre-to-post-season activity. Scores Post-Concussive Symptom Inventory correlated determine their relevance. Results Concussion was increased exponents superior frontal cortices, indicating relative reduction This slowing neurophysiology mediated raw delta gamma power worse cognitive concerns across participants. Pre-to-post-season aperiodic-corrected alpha theta rhythmic also decreased posterior cortices concussed players. Conclusion These findings indicate that alters both excitability signaling cortex, differing spatial topographies implications Key reduces cortices. accounts canonical power. Concussion-related symptom severity.

Language: Английский

EEG Spectral Exponents and Visual Chirp Responses Mirror Anti‐Seizure Medication Load in Refractory Focal Epilepsy DOI Creative Commons
Silvano R. Gefferie, Arthur R. van Nieuw Amerongen, Gerhard H. Visser

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

ABSTRACT Objective Quantitative markers of cortical excitability may help identify responders to anti‐seizure medications (ASMs). We studied the relationship between ASM load and two electroencephalography (EEG) in people with refractory epilepsy. Methods included individuals focal epilepsy undergoing presurgical evaluation, involving tapering sleep deprivation. obtained daily resting state EEG responses visual stimulation at linearly increasing flash frequency (10–40 Hz chirp). extracted aperiodic exponent from power spectra analysed chirp response driving second‐order harmonic frequencies. modelled load, which we related using linear mixed‐effects regression. Results Forty‐eight subjects (median age 34 years, range 16–62 19 females) participated. The spectral became less negative reduction ( p = 0.02), mainly attributable reduced low‐frequency power. Lowering increased 0.004), also after accounting for deprivation but did not affect response. specifically high frequencies (27–40 Hz, 0.01). Interpretation Resting exponents reflect Low‐frequency changes only mirror ASM‐induced slowing. Visual reveals enhanced during low loads, likely due both gamma activity perturbations. Implementation would need normative values reduce delay individually optimised treatment regimens.

Language: Английский

Citations

0
Cerebellar Contributions to Hypokinetic Symptoms in an Acute Lesion Parkinsonism Model DOI Creative Commons
Cristofer Zarate-Calderon, Gerardo Marín, Iraís Viveros-Martínez

et al.

Neurology International, Journal Year: 2025, Volume and Issue: 17(5), P. 72 - 72

Published: May 7, 2025

Background: Parkinsonism, characterized by motor symptoms, is typically attributed to basal ganglia dysfunction. Recent evidence suggests that the cerebellum may also influence these symptoms. This study investigated Crus II, dentate nucleus (DN), and inferior olive (IO) in a rat model of parkinsonism induced bilateral ventrolateral striatal (VLS) lesion. Materials Methods: Twenty-four male Wistar rats were divided into control (n = 12) experimental groups. Monopolar electrodes implanted target structures. The group received VLS Animals underwent four weekly sessions electrophysiological recordings blind behavioral assessments (resting, grooming, locomotion, rearing, sniffing) via video tracking. Power spectral density (PSD) 300–500 Hz band was computed. Statistical analyses included Mann–Whitney U, Friedman with Wilcoxon post hoc, Spearman correlation tests. Results: During weeks one two, there significant PSD increases compared control, particularly II—grooming (p 0.005), locomotion 0.007), rearing 0.026); IO—sniffing 0.0167); DN—grooming < 0.001) 0.0008). Additionally, intragroup analysis revealed elevations relative baseline Significant correlations observed only for grooming (negative correlations) sniffing (positive across all cerebellar regions. Conclusions: These findings suggest compensatory hyperactivity lesion, potentially modulating hypokinetic symptoms highlighting dynamic network interactions. Interpretation warrants caution due limitations inherent acute lesion duration.

Language: Английский

Citations

0
Reduced Cortical Excitability is Associated with Cognitive Symptoms in Concussed Adolescent Football Players DOI Creative Commons
Kevin Yu, Alex I. Wiesman, Elizabeth M. Davenport

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Abstract Background American tackle football is associated with high rates of concussion, leading to neurophysiological disturbances and debilitating clinical symptoms. Previous investigations the effects concussion have largely ignored aperiodic activity, which a marker cortical excitability. Purpose We examined whether during season school related changes in periodic activity any such are outcomes. Materials Methods Pre- post-season resting-state magnetoencephalography (MEG) data were collected from 91 players over as many four seasons play, for total 278 collections. During these cohort 10 individuals diagnosed concussion. MEG source-imaged, frequency-transformed parameterized, linear mixed models used examine on pre-to-post-season activity. Scores Post-Concussive Symptom Inventory correlated determine their relevance. Results Concussion was increased exponents superior frontal cortices, indicating relative reduction This slowing neurophysiology mediated raw delta gamma power worse cognitive concerns across participants. Pre-to-post-season aperiodic-corrected alpha theta rhythmic also decreased posterior cortices concussed players. Conclusion These findings indicate that alters both excitability signaling cortex, differing spatial topographies implications Key reduces cortices. accounts canonical power. Concussion-related symptom severity.

Language: Английский

Citations

0