Enhanced presynaptic mitochondrial energy production is required for memory formation

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 2, 2023

Some of the prominent features long-term memory formation include protein synthesis, gene expression, enhanced neurotransmitter release, increased excitability, and new synapses. As these processes are critically dependent on mitochondrial function, we hypothesized that respiration dynamics would play a role in formation. To address this possibility, measured oxygen consumption (OCR) hippocampal tissue punches from trained untrained animals. Our results show context fear training significantly basal, ATP synthesis-linked, maximal OCR Shaffer collateral-CA1 synaptic region, but not CA1 cell body layer. These changes were recapitulated synaptosomes isolated hippocampi fear-trained dynamin-related 1 (Drp1) plays an important fission, examined its observed after training. Drp1 inhibitors decreased training-associated enhancement impaired contextual memory, did alter number containing mitochondria. Taken together, our increases presynaptic mitochondria respiration, Drp-1 mediated energy production pre-synaptic terminals is necessary for does result increase or mass within

Language: Английский

J147 Treatment Protects Against Traumatic Brain Injury by Inhibiting Neuronal Endoplasmic Reticulum Stress Potentially via the AMPK/SREBP-1 Pathway

Translational research, Journal Year: 2024, Volume and Issue: 274, P. 21 - 34

Published: Sept. 7, 2024

Language: Английский