Dnajc3(HSP40) Modulates Axon Regeneration in the Mouse Optic Nerve DOI Open Access
Jiaxing Wang, Ying Li, Felix L. Struebing

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

A forward genetics approach was used to identify genomic elements enhancing axon regeneration in the BXD recombinant mouse strains. Axon induced by knocking down

Language: Английский

Modulating amacrine cell–derived dopamine signaling promotes optic nerve regeneration and preserves visual function DOI Creative Commons
Qi Zhang,

Jingfei Xue,

J. Tang

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(31)

Published: Aug. 2, 2024

As part of the central nervous system, optic nerve, composed axons from retinal ganglion cells (RGCs), generally fails to regenerate on its own when injured in adult mammals. An innovative approach promoting nerve regeneration involves manipulating interactions between amacrine (ACs) and RGCs. Here, we identified a unique AC subtype, dopaminergic ACs (DACs), that responded early after crush by down-regulating neuronal activity reducing dopamine (DA) release. Activating DACs or augmenting DA release with levodopa demonstrated neuroprotective effects modestly enhanced axon regeneration. Within this context, pinpointed receptor D1 (DRD1) as critical mediator DAC-derived showed RGC-specific Drd1 overexpression effectively overcame subtype-specific barriers This strategy markedly boosted RGC survival preserved vision glaucoma model. study unveils crucial role signaling regeneration, holding promise for therapeutic insights into neural repair.

Language: Английский

Citations

4
TRPA1 exacerbates selective retinal ganglion cell vulnerability under acute ocular hypertension DOI Creative Commons
Wenhan Lu, Yu Wang, Wei Hu

et al.

Acta Neuropathologica Communications, Journal Year: 2025, Volume and Issue: 13(1)

Published: April 5, 2025

Language: Английский

Citations

0
CaMK2A/CREB pathway activation is associated with enhanced mitophagy and neuronal apoptosis in diabetic retinopathy DOI Creative Commons

Xiaochun Yang,

Yuxin Zhang,

Yikun Zhou

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 11, 2025

Language: Английский

Citations

0
Emerging therapeutic strategies for optic nerve regeneration DOI Creative Commons
Qi Zhang, J. Tang, Liyan Liu

et al.

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 46(1), P. 45 - 61

Published: Dec. 17, 2024

Language: Английский

Citations

1
Dnajc3(HSP40) Modulates Axon Regeneration in the Mouse Optic Nerve DOI Open Access
Jiaxing Wang, Ying Li, Felix L. Struebing

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

A forward genetics approach was used to identify genomic elements enhancing axon regeneration in the BXD recombinant mouse strains. Axon induced by knocking down

Language: Английский

Citations

0