Spreading Processes in Complex Networks of Cultured Neurons and Society DOI Creative Commons
F. Paul Spitzner

Published: Jan. 1, 2023

Complex networks appear across various contexts of our lives. Telecommunication, transport, infrastructure and finance are candidates to come mind, we humans ourselves, just going about day as usual, meeting others, create a complex network contacts. Also in bodies, can find intricate networks, not metabolic molecular interactions, but structural sense. As particular example, consider the human brain, where cortex alone is built 16 × 10^9 neurons, forming far-from-random structures. These form backbone on which spreading processes unfold, and, many cases, heterogeneities this alter dynamics compared homogeneous network. In thesis, discuss two examples aspects interplay with process give rise remarkable emergent dynamics: i) well-controlled neuronal system, vitro cultures cortical neurons that engineered feature modular topology. Notably, systems, structure only activity propagation also represents information storage, memories formed through long-lasting changes connection strength between neurons. One could say knowledge. ii) an example disease spread contact network, explore face-to-face data university students study patterns progression. both examples, models go beyond unfolding static We take into account isolated interactions environment lead unforeseen dynamics.

Language: Английский

The emergence of multiscale connectomics-based approaches in stroke recovery DOI Creative Commons
Shahrzad Latifi, S. Thomas Carmichael

Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(4), P. 303 - 318

Published: Feb. 23, 2024

Stroke is a leading cause of adult disability. Understanding stroke damage and recovery requires deciphering changes in complex brain networks across different spatiotemporal scales. While recent developments readout technologies progress network modeling have revolutionized current understanding the effects on at macroscale, reorganization smaller scale remains incompletely understood. In this review, we use conceptual framework graph theory to define from nano- macroscales. Highlighting stroke-related connectivity studies multiple scales, argue that multiscale connectomics-based approaches may provide new routes better evaluate structural functional remapping after during recovery.

Language: Английский

Citations

10
Psychedelics and disorders of consciousness: the current landscape and the path forward DOI Creative Commons
Paolo Cardone, Naji Alnagger, Jitka Annen

et al.

Neuroscience of Consciousness, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Modern medicine has been shaken by the surge of psychedelic science that proposes a new approach to mitigate mental disorders, such as depression and post-traumatic stress disorder. Clinical trials investigate whether substances can treat psychiatric conditions are now underway, yet less discussion gravitates around their use in neurological disorders due brain injury. One suggested implementation brain-complexity enhancing psychedelics is people with post-comatose consciousness (DoC). In this article, we discuss rationale endeavour, examining possible outcomes experiments postulating existence an optimal level complexity. We consider counterintuitive effects both DoC on functional connectivity default mode network its impact selfhood. also elaborate role computational modelling providing complementary information experimental studies, contributing our understanding treatment mechanisms path towards personalized medicine. Finally, update discourse surrounding ethical considerations, encompassing clinical scientific values.

Language: Английский

Citations

5
Eslicarbazepine, a third-generation anti-seizure medication, inhibits INa but stimulates IK(M) DOI
Te‐Yu Hung, Sheng‐Nan Wu, Chin‐Wei Huang

et al.

Neurochemistry International, Journal Year: 2025, Volume and Issue: unknown, P. 105990 - 105990

Published: May 1, 2025

Language: Английский

Citations

0
The recovery of parabolic avalanches in spatially subsampled neuronal networks at criticality DOI Creative Commons

Keshav Srinivasan,

Tiago L. Ribeiro,

Patrick Kells

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Scaling relationships are key in characterizing complex systems at criticality. In the brain, they evident neuronal avalanches-scale-invariant cascades of activity quantified by power laws. Avalanches manifest cellular level as groups that fire action potentials simultaneously. Such spatiotemporal synchronization is vital to theories on brain function yet avalanche often underestimated when only a fraction neurons observed. Here, we investigate biases from fractional sampling within balanced network excitatory and inhibitory with all-to-all connectivity critical branching process dynamics. We focus how mean size scales duration. For parabolic avalanches, this scaling quadratic, exponent,

Language: Английский

Citations

2
Spontaneous Brain Activity Emerges from Pairwise Interactions in the Larval Zebrafish Brain DOI Creative Commons
Richard Rosch,

Dominic R. W. Burrows,

Christopher W. Lynn

et al.

Physical Review X, Journal Year: 2024, Volume and Issue: 14(3)

Published: Sept. 23, 2024

Brain activity is characterized by brainwide spatiotemporal patterns that emerge from synapse-mediated interactions between individual neurons. Calcium imaging provides access to in vivo recordings of whole-brain at single-neuron resolution and, therefore, allows the study how large-scale brain dynamics local activity. In this study, we use a statistical mechanics approach-the pairwise maximum entropy model-to infer microscopic network features collective larval zebrafish and relate these emergence observed dynamics. Our findings indicate neural populations their intrinsic states are sufficient explain fact, relationships neuronal estimated with model strongly correspond structural connectivity patterns. Model simulations also demonstrated tuning drives transitions physiological regimes pathologically hyperexcitable regimes. Finally, virtual resection identify structures important for maintaining dynamic regime. Together, our results emerges complex dynamical system basins attraction whose strength topology depend on areas.

Language: Английский

Citations

2
The recovery of parabolic avalanches in spatially subsampled neuronal networks at criticality DOI Creative Commons

Keshav Srinivasan,

Tiago L. Ribeiro,

Patrick Kells

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 20, 2024

Scaling relationships are key in characterizing complex systems at criticality. In the brain, they evident neuronal avalanches-scale-invariant cascades of activity quantified by power laws. Avalanches manifest cellular level as groups that fire action potentials simultaneously. Such spatiotemporal synchronization is vital to theories on brain function yet avalanche often underestimated when only a fraction neurons observed. Here, we investigate biases from fractional sampling within balanced network excitatory and inhibitory with all-to-all connectivity critical branching process dynamics. We focus how mean size scales duration. For parabolic avalanches, this scaling quadratic, exponent, χ = 2, reflecting rapid spatial expansion simultaneous firing over short durations. However, networks sampled fractionally, significantly lower. demonstrate applying temporal coarse-graining increasing minimum threshold for coincident restores even few 0.1% sampled. This correction crucially depends being fails near sub- supercritical Using 2-photon imaging, our approach robustly identifies 2 wide parameter regime ongoing frontal cortex awake mice. contrast, common 'crackling noise' determine under similar conditions Our findings overcome bias rapid, assemblies consistent scale-invariant, avalanches

Language: Английский

Citations

1
In Vivo Calcium and Neurotransmitter Fluorescence Imaging in Acute Models of Epilepsy DOI
R. Graham, Yoshiteru Shimoda, Amy Richardson

et al.

Neuromethods, Journal Year: 2024, Volume and Issue: unknown, P. 83 - 109

Published: Jan. 1, 2024

Language: Английский

Citations

0
Focal seizures induce spatiotemporally organized spiking activity in the human cortex DOI Creative Commons
Joshua M. Diamond, Julio I. Chapeton, Weizhen Xie

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 16, 2024

Abstract Epileptic seizures are debilitating because of the clinical symptoms they produce. These symptoms, in turn, may stem directly from disruptions neural coding. Recent evidence has suggested that specific temporal order, or sequence, spiking across a population cortical neurons encode information. Here, we investigate how disrupt neuronal sequences human brain by recording multi-unit activity cerebral cortex five male participants undergoing monitoring for seizures. We find pathological discharges during associated with bursts neurons. organized into highly consistent and stereotyped sequences. As seizure evolves, diverge observed at baseline become more spatially organized. The direction this spatial organization matches ictal discharges, which spread over as traveling waves. Our data therefore suggest can entrain changing firing, providing possible mechanism create symptoms.

Language: Английский

Citations

0
Epilepsy insights revealed by intravital functional optical imaging DOI Creative Commons
Matthew Stern, Raymond Dingledine, Robert A. Gross

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 29, 2024

Despite an abundance of pharmacologic and surgical epilepsy treatments, there remain millions patients suffering from poorly controlled seizures. One approach to closing this treatment gap may be found through a deeper mechanistic understanding the network alterations that underly aberrant activity. Functional optical imaging in vertebrate models provides powerful advantages end, enabling spatiotemporal acquisition individual neuron activity patterns across multiple This coupled with advent genetically encoded indicators, them for specific ions, neurotransmitters or voltage, grants researchers unparalleled access intact nervous system. Here, we will review how vivo functional various seizure has advanced our knowledge dynamics, principally initiation, propagation termination.

Language: Английский

Citations

0
Dynamic reconfiguration of aperiodic brain activity supports cognitive functioning in epilepsy - a neural-fingerprint identification DOI Creative Commons
Emahnuel Troisi Lopez, Marie‐Constance Corsi, Alberto Danieli

et al.

iScience, Journal Year: 2024, Volume and Issue: 28(1), P. 111497 - 111497

Published: Nov. 29, 2024

Language: Английский

Citations

0