Mapping social reward and punishment processing in the human brain: A voxel-based meta-analysis of neuroimaging findings using the social incentive delay task

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 122, P. 1 - 17

Published: Jan. 8, 2021

Language: Английский

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Thalamocortical excitability modulation guides human perception under uncertainty

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 23, 2021

Abstract Knowledge about the relevance of environmental features can guide stimulus processing. However, it remains unclear how processing is adjusted when feature uncertain. We hypothesized that (a) heightened uncertainty would shift cortical networks from a rhythmic, selective processing-oriented state toward an asynchronous (“excited”) boosts sensitivity to all features, and (b) thalamus provides subcortical nexus for such uncertainty-related shifts. Here, we had young adults attend varying numbers task-relevant during EEG fMRI acquisition test these hypotheses. Behavioral modeling electrophysiological signatures revealed greater lowered rate evidence accumulation individual shifted cortex rhythmic asynchronous/excited regime, neuromodulatory arousal. Crucially, this unified constellation within-person effects was dominantly reflected in uncertainty-driven upregulation thalamic activity. argue processes involving play central role brain modulates neural excitability face momentary uncertainty.

Language: Английский

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A thalamic bridge from sensory perception to cognition

Neuroscience & Biobehavioral Reviews, Journal Year: 2020, Volume and Issue: 120, P. 222 - 235

Published: Nov. 24, 2020

The ability to adapt dynamic environments requires tracking multiple signals with variable sensory salience and fluctuating behavioral relevance. This complex process integrative crosstalk between cognitive brain circuits. Functional interactions cortical thalamic regions are now considered essential for both perception cognition but a clear account of the functional link circuits is currently lacking. review aims document how nuclei may effectively act as bridge allowing fuse perceptual events into meaningful experiences. After highlighting key aspects thalamocortical such classic first-order/higher-order dichotomy, we consider role reticular nucleus from directed attention cognition. We next summarize research relying on Pavlovian learning paradigms, showing that first-order higher-order contribute associative learning. Finally, propose modulator inputs reaching all be critical purposes when environmental computed. Altogether, thalamus appears linking perception, possibly affect.

Language: Английский

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Wnt/β‐catenin signaling in brain development and mental disorders: keeping TCF7L2 in mind

FEBS Letters, Journal Year: 2019, Volume and Issue: 593(13), P. 1654 - 1674

Published: June 20, 2019

Canonical Wnt signaling, which is transduced by β‐catenin and lymphoid enhancer factor 1/T cell‐specific transcription factors (LEF1/TCFs), regulates many aspects of metazoan development tissue renewal. Although much evidence has associated canonical Wnt/β‐catenin signaling with mood disorders, the mechanistic links are still unknown. Many components pathway involved in cellular processes that unrelated to classical thus further blurring picture. The present review critically evaluates involvement developmental putatively underlie pathology mental illnesses. Particular attention given roles LEF1/TCFs, have been discussed surprisingly rarely this context. Highlighting recent discoveries, we propose alterations activity particularly 7‐like 2 (TCF7L2), result defects previously neuropsychiatric including imbalances neurogenesis oligodendrogenesis, functional disruption thalamocortical circuitry dysfunction habenula.

Language: Английский

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The anterior thalamic nuclei and cognition: A role beyond space?

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 126, P. 1 - 11

Published: March 18, 2021

The anterior thalamic nuclei are a vital node within hippocampal-diencephalic-cingulate circuits that support spatial learning and memory. Reflecting this interconnectivity, the overwhelming focus of research into cognitive functions has been processing. However, there is increasing evidence extend beyond realm. This work highlighted how these required for certain classes temporal discrimination as well their importance processing other contextual information; revealing parallels with non-spatial hippocampal formation. Yet further shown may be important forms learning, including critical role in attentional mechanisms. signals need to reconsider framework wider connections sites cingulate cortex subserve functions.

Language: Английский

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Mental Stress and Cardiovascular Health—Part I

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(12), P. 3353 - 3353

Published: June 10, 2022

Epidemiological studies have shown that a substantial proportion of acute coronary events occur in individuals who lack the traditional high-risk cardiovascular (CV) profile. Mental stress is an emerging risk and prognostic factor for artery disease stroke, independently conventional factors. It associated with increased rate CV events. Acute mental may develop as result anger, fear, or job strain, well consequence earthquakes hurricanes. Chronic long-term repetitive exposure, such job-related stress, low socioeconomic status, financial problems, depression, type A D personality. While response to events, relationship chronic (CAD) mainly due acceleration atherosclerosis. Emotionally stressful stimuli are processed by network cortical subcortical brain regions, including prefrontal cortex, insula, amygdala, hypothalamus, hippocampus. This system involved interpretation relevance environmental stimuli, according individual’s memory, past experience, current context. The transduces cognitive process emotional into hemodynamic, neuroendocrine, immune changes, called fight flight response, through autonomic nervous hypothalamic–pituitary–adrenal axis. These changes induce transient myocardial ischemia, defined stress-induced ischemia (MSIMI) patients without significant obstruction. clinical consequences be angina, infarction, arrhythmias, left ventricular dysfunction. Although MSIMI increase mortality, it usually underestimated because arises pain most cases. occurs at lower levels cardiac work than exercise-induced suggesting impairment blood flow paradoxical vasoconstriction microvascular

Language: Английский

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The role of the anterior nuclei of the thalamus in human memory processing

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 126, P. 146 - 158

Published: March 18, 2021

Language: Английский

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Neural mechanisms of domain-general inhibitory control

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 28(2), P. 124 - 143

Published: Oct. 26, 2023

Language: Английский

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Intensive whole-brain 7T MRI case study of volitional control of brain activity in deep absorptive meditation states

Cerebral Cortex, Journal Year: 2023, Volume and Issue: 34(1)

Published: Nov. 6, 2023

Abstract Jhanas are profound states of mind achieved through advanced meditation, offering valuable insights into the nature consciousness and tools to enhance well-being. Yet, its neurophenomenology remains limited due methodological difficulties rarity meditation practitioners. We conducted a highly exploratory study investigate jhanas in an intensively sampled adept meditator case (4 hr 7T fMRI collected 27 sessions) who performed jhana rated specific aspects experience immediately thereafter. Linear mixed models correlations were used examine relations among brain activity phenomenology. identified distinctive patterns cortical, subcortical, brainstem, cerebellar regions associated with jhana. Furthermore, we observed between phenomenological qualities attention, jhanic qualities, narrative processing, highlighting distinct compared non-meditative states. Our presents most rigorous evidence yet that practice deconstructs consciousness, unique significant implications for mental health

Language: Английский

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Volitional mental absorption in meditation: Toward a scientific understanding of advanced concentrative absorption meditation and the case of jhana

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31223 - e31223

Published: May 1, 2024

Meditation has been integral to human culture for millennia, deeply rooted in various spiritual and contemplative traditions. While the field of science made significant steps toward understanding effects meditation on health well-being, there little study advanced meditative states, including those achieved through intense concentration absorption. We refer these types states as concentrative absorption (ACAM), characterized by with object leading heightened attention, clarity, energy, effortlessness, bliss. This review focuses a type ACAM known jhana (ACAM-J) due its well-documented history, systematic practice approach, recurring phenomenological themes, growing popularity among scientists more generally media society. ACAM-J encompasses eight layers deep concentration, awareness, internal experiences. Here, we describe phenomenology present evidence from neuroscientific studies that highlight their potential applications practices, psychological sciences, therapeutics. additionally propose theoretical frameworks grounded current cognitive ancient aim stimulate further research broadly, encompassing development endpoints. Studying ACAM, specific practices such ACAM-J, can potentially revolutionize our consciousness mental health.

Language: Английский

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