Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction DOI Creative Commons
Daisuke Miyamoto,

Mahmoud Abdelmouti Mahmoud

Molecular Brain, Journal Year: 2024, Volume and Issue: 17(1)

Published: Nov. 29, 2024

Abstract Trace and delay auditory fear conditioning involve different memory association strategies based on working involvement; however, their differences in long-term processing through sleep extinction training remain unclear. While females often exhibit more persistent fear, complicating psychiatric treatment, most studies have primarily focused how affects initial recall male mice. We investigated the three-way interaction between tests (trace vs. delay), states, sex during recall, extinction, post-extinction remote recall. A six-hour post-conditioning deprivation (SD) did not affect freezing behavior following day’s of memory. However, memory, SD prevented spontaneous recovery males reduced females. In contrast, rapidly facilitated trace summary, enhances both short-term long-term, depending protocol. These findings highlight importance assessments to explore interactions among emotional sleep, differences, with implications for individualized mechanisms underlying post-traumatic stress disorder (PTSD) its treatments.

Language: Английский

Post-conditioning sleep deprivation facilitates delay and trace fear memory extinction DOI Creative Commons
Daisuke Miyamoto,

Mahmoud Abdelmouti Mahmoud

Molecular Brain, Journal Year: 2024, Volume and Issue: 17(1)

Published: Nov. 29, 2024

Abstract Trace and delay auditory fear conditioning involve different memory association strategies based on working involvement; however, their differences in long-term processing through sleep extinction training remain unclear. While females often exhibit more persistent fear, complicating psychiatric treatment, most studies have primarily focused how affects initial recall male mice. We investigated the three-way interaction between tests (trace vs. delay), states, sex during recall, extinction, post-extinction remote recall. A six-hour post-conditioning deprivation (SD) did not affect freezing behavior following day’s of memory. However, memory, SD prevented spontaneous recovery males reduced females. In contrast, rapidly facilitated trace summary, enhances both short-term long-term, depending protocol. These findings highlight importance assessments to explore interactions among emotional sleep, differences, with implications for individualized mechanisms underlying post-traumatic stress disorder (PTSD) its treatments.

Language: Английский

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