Disruption of transthalamic circuitry from primary visual cortex impairs visual discrimination in mice DOI Creative Commons

C. McKinnon,

Christina Mo, S. Murray Sherman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

ABSTRACT Layer 5 (L5) of the cortex provides strong driving input to higher-order thalamic nuclei, such as pulvinar in visual system, forming basis cortico-thalamo-cortical (transthalamic) circuits. These circuits provide a communication route between cortical areas parallel direct corticocortical connections, but their specific role perception and behavior remains unclear. Using targeted optogenetic inhibition mice performing discrimination task, we selectively suppressed corticothalamic from L5 cells primary (V1) at terminals pulvinar. This suppresses transthalamic V1; furthermore, any effect on projections local V1 circuitry would thus result inputs (e.g., back (Miller-Hansen Sherman, 2022). Such suppression processing during stimulus presentation drifting gratings significantly impaired performance across different orientations. The impact was portion space that retinotopically coincided with inhibition. results highlight importance incorporating L5-initiated into frameworks, particularly those addressing how hierarchical propagation sensory signals supports perceptual decision-making. SIGNIFICANCE STATEMENT Appreciation pathways for areas, organized has transformed our thinking about functioning writ large. Studies initially concentrated anatomy physiology, there been shift towards understanding cognitive behavior. Here, have used an approach inhibit pathway other itself. We find degrades animals’ ability discriminate, showing first time reduces discrimination. causal data adds growing evidence signaling processing.

Language: Английский

Disruption of transthalamic circuitry from primary visual cortex impairs visual discrimination in mice DOI Creative Commons

C. McKinnon,

Christina Mo, S. Murray Sherman

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

ABSTRACT Layer 5 (L5) of the cortex provides strong driving input to higher-order thalamic nuclei, such as pulvinar in visual system, forming basis cortico-thalamo-cortical (transthalamic) circuits. These circuits provide a communication route between cortical areas parallel direct corticocortical connections, but their specific role perception and behavior remains unclear. Using targeted optogenetic inhibition mice performing discrimination task, we selectively suppressed corticothalamic from L5 cells primary (V1) at terminals pulvinar. This suppresses transthalamic V1; furthermore, any effect on projections local V1 circuitry would thus result inputs (e.g., back (Miller-Hansen Sherman, 2022). Such suppression processing during stimulus presentation drifting gratings significantly impaired performance across different orientations. The impact was portion space that retinotopically coincided with inhibition. results highlight importance incorporating L5-initiated into frameworks, particularly those addressing how hierarchical propagation sensory signals supports perceptual decision-making. SIGNIFICANCE STATEMENT Appreciation pathways for areas, organized has transformed our thinking about functioning writ large. Studies initially concentrated anatomy physiology, there been shift towards understanding cognitive behavior. Here, have used an approach inhibit pathway other itself. We find degrades animals’ ability discriminate, showing first time reduces discrimination. causal data adds growing evidence signaling processing.

Language: Английский

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