Retinal ganglion cells encode the direction of motion outside their classical receptive field DOI Creative Commons
Serena Riccitelli, Hadar Yaakov, Alina S. Heukamp

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 122(1)

Published: Dec. 30, 2024

Retinal ganglion cells (RGCs) typically respond to light stimulation over their spatially restricted receptive field. Using large-scale recordings in the mouse retina, we show that a subset of non- direction-selective (DS) RGCs exhibit asymmetric activity, selective motion direction, response stimulus crossing an area far beyond classic The extraclassical arises via inputs from distal zone and is enhanced by desensitization mechanisms inherent DS component, creating network neurons responding toward optic disc. Pharmacological manipulations revealed necessity glycinergic amacrine for this response. vivo recordings, identified similar responses lateral geniculate nucleus neurons, suggesting such non conventional information transferred downstream structures. Our results suggest complex integration direction processing across visual field, which classical field boundaries.

Language: Английский

Mammalian Retinal Bipolar Cells: Morphological Identification and Systematic Classification in Rabbit Retina With a Comparative Perspective DOI
Edward V. Famiglietti

The Journal of Comparative Neurology, Journal Year: 2025, Volume and Issue: 533(2)

Published: Feb. 1, 2025

ABSTRACT Retinal bipolar cells (BCs) convey visual signals from photoreceptors to more than 50 types of rabbit retinal ganglion (Famiglietti, 2020). More 40 years ago, 10–11 were recognized in and cat retinas 1981). Twenty later, 10 identified mouse, rat, monkey, while recent molecular genetic studies indicate that there are 15 cell mouse retina (Shekhar et al., 2016). The present detailed study 800 11 Golgi‐impregnated indicates 14–16 cone one type rod retina. These have been carefully analyzed terms dendritic axonal morphology axon terminal stratification with respect fiducial starburst amacrine cells. In fortuitous proximity, several can be related by contacts suggestive synaptic connection. results compared other Homologies monkey considered functional terms.

Language: Английский

Citations

0
Dendritic Architecture Enables de Novo Computation of Salient Motion in the Superior Colliculus DOI Creative Commons
Norma K. Kühn, Chen Li,

Natalia Baimacheva

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Dendritic architecture plays a crucial role in shaping how neurons extract behaviorally relevant information from sensory inputs. Wide-field the superior colliculus integrate visual retina to encode cues critical for visually guided orienting behaviors. However, principles governing these filter their inputs generate appropriate responses remain unclear. Using viral tracing, two-photon calcium imaging, and computational modeling, we show that wide-field receive functionally diverse twelve retinal ganglion cell types, forming layered, type-specific organization along dendrites. This structured arrangement allows multiplex salient motion cues, selectively amplifying movement suppressing static features. Computational models reveal spatial of dendrites enables selective extraction stimuli, including de novo computations. Our findings underscore dendritic processing neural circuit function.

Language: Английский

Citations

0
Mammalian Retinal Bipolar Cells: Morphological Identification and Systematic Classification in Rabbit Retina, with a Comparative Perspective DOI
Edward V. Famiglietti

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Abstract Retinal bipolar cells (BCs) convey visual signals from photoreceptors to more than 50 types of rabbit retinal ganglion (Famiglietti, 2020). More 40 years ago, 10-11 cell were recognized in and cat retinas 1981). Twenty later 10 identified mouse, rat, monkey (Gosh et al., 2004), while recent molecular genetic studies indicate that there are 15 mouse retina (Shekhar 2016). The present detailed study 800 ten Golgi-impregnated indicates 14-16 cone one type rod retina. These have been carefully analyzed terms dendritic axonal morphology, axon terminal stratification with respect fiducial starburst amacrine cells. In fortuitous proximity, several can be related by contacts suggestive synaptic connection. results compared other Homologies considered functional terms.

Language: Английский

Citations

2
Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells DOI Creative Commons

Wanyu Lei,

Damon A. Clark, Jonathan B. Demb

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(49)

Published: Nov. 27, 2024

Orientation is one of the most salient features in visual scenes. Neurons at multiple levels system detect orientation, but many cases, underlying biophysical mechanisms remain unresolved. Here, we studied for orientation detection earliest stage system, B/K wide-field amacrine cells (B/K WACs), a group giant, nonspiking interneurons mouse retina that coexpress Bhlhe22 (B) and Kappa Opioid Receptor (K). WACs exhibit orientation-tuned calcium signals along their long, straight, unbranching dendrites, which contain both synaptic inputs outputs. Simultaneous dendritic imaging somatic voltage recordings reveal individual dendrites are electrotonically isolated, exhibiting spatially confined yet extended receptive field dendrite, term “compartmentalized pooling.” Further, WAC dendrite exhibits center-surround antagonism. Phenomenological models demonstrate compartmentalized pooling generates selectivity, antagonism shapes band-pass spatial frequency tuning. At microcircuit level, receive excitation driven by contrast polarity (e.g., “ON”) glycinergic inhibition opposite “OFF”). However, this “crossover” not essential generating selectivity. A minimal model reproduced from feedforward excitatory combined with substantial increase specific membrane resistance between compartments. Collectively, our results mechanism selectivity WACs, enriching understanding diverse strategies employed throughout to orientation.

Language: Английский

Citations

1
The role of REM sleep in neural differentiation of memories in the hippocampus DOI Creative Commons
Elizabeth A. McDevitt,

Ghootae Kim,

Nicholas B. Turk‐Browne

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 3, 2024

When faced with a familiar situation, we can use memory to make predictions about what will happen next. If such turn out be erroneous, the brain adapt by differentiating representations of cues that generated prediction from mispredicted item itself, reducing likelihood future errors. Prior work Kim et al. (2017) found violating sequential association in statistical learning paradigm triggered differentiation neural associated items hippocampus. Here, used fMRI test preregistered hypothesis this hippocampal occurs only when violations are followed rapid eye movement (REM) sleep. In morning, participants first learned some predict others (e.g., A predicts B) then encountered violation which predicted (B) failed appear expected after its (A); later appeared on own an unrelated item. Participants were randomly assigned one three conditions: remain awake, take nap containing non-REM sleep only, or both and REM While results not observed left CA2/3/DG ROI, did observe evidence for our closely related ROIs, uncorrected multiple comparisons: right CA2/3/DG, group was greater than groups without (wake nap); item-specific concentrated DG. Differentiation effects also bilateral DG more strongly reactivated during violation. Overall, presented here provide initial linking changes memories humans.

Language: Английский

Citations

0
Retinal ganglion cells encode the direction of motion outside their classical receptive field DOI Creative Commons
Serena Riccitelli, Hadar Yaakov, Alina S. Heukamp

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 122(1)

Published: Dec. 30, 2024

Retinal ganglion cells (RGCs) typically respond to light stimulation over their spatially restricted receptive field. Using large-scale recordings in the mouse retina, we show that a subset of non- direction-selective (DS) RGCs exhibit asymmetric activity, selective motion direction, response stimulus crossing an area far beyond classic The extraclassical arises via inputs from distal zone and is enhanced by desensitization mechanisms inherent DS component, creating network neurons responding toward optic disc. Pharmacological manipulations revealed necessity glycinergic amacrine for this response. vivo recordings, identified similar responses lateral geniculate nucleus neurons, suggesting such non conventional information transferred downstream structures. Our results suggest complex integration direction processing across visual field, which classical field boundaries.

Language: Английский

Citations

0