A critical review of ethanol effects on neuronal firing: A metabolic perspective
Alcohol Clinical and Experimental Research,
Journal Year:
2024,
Volume and Issue:
48(3), P. 450 - 458
Published: Jan. 12, 2024
Abstract
Ethanol
metabolism
is
relatively
understudied
in
neurons,
even
though
changes
neuronal
are
known
to
affect
their
activity.
Recent
work
demonstrates
that
ethanol
preferentially
metabolized
over
glucose
as
a
source
of
carbon
and
energy,
it
reprograms
neurons
state
reduced
energy
potential
diminished
capacity
utilize
once
exhausted.
intake
has
been
associated
with
firing
specific
brain
activity
(EEG)
patterns
have
linked
risk
for
alcohol
use
disorder
(AUD).
Furthermore,
haplotype
the
inwardly
rectifying
potassium
channel
subunit,
GIRK2,
which
plays
critical
role
regulating
excitability
AUD
shown
be
directly
regulated
by
ethanol.
At
same
time,
overexpression
GIRK2
prevents
ethanol‐induced
metabolic
changes.
Based
on
available
evidence,
we
conclude
mechanisms
underlying
effects
novel
target
developing
therapies
AUD.
Language: Английский
Epilepsy in a mouse model of GNB1 encephalopathy arises from altered potassium (GIRK) channel signaling and is alleviated by a GIRK inhibitor
Frontiers in Cellular Neuroscience,
Journal Year:
2023,
Volume and Issue:
17
Published: May 18, 2023
mutations
in
Language: Английский
Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels
Frontiers in Physiology,
Journal Year:
2024,
Volume and Issue:
15
Published: June 6, 2024
Ion
channels
play
a
pivotal
role
in
regulating
cellular
excitability
and
signal
transduction
processes.
Among
the
various
ion
channels,
G-protein-coupled
inwardly
rectifying
potassium
(GIRK)
serve
as
key
mediators
of
neurotransmission
responses
to
extracellular
signals.
GIRK
are
members
larger
family
inwardly-rectifying
(Kir)
channels.
Typically,
activated
via
direct
binding
G-protein
βγ
subunits
upon
activation
receptors
(GPCRs).
channel
requires
presence
lipid
signaling
molecule,
phosphatidylinositol
4,5-bisphosphate
(PIP
Language: Английский