Reuniens thalamus recruits recurrent excitation in medial prefrontal cortex. DOI Creative Commons
Gil Vantomme, Gabrielle Devienne, Jacob M. Hull

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Medial prefrontal cortex (mPFC) and hippocampus are critical for memory retrieval, decision making emotional regulation. While ventral CA1 (vCA1) shows direct reciprocal connections with mPFC, dorsal (dCA1) forms indirect pathways to notably via the thalamic Reuniens nucleus (Re). Neuroanatomical tracing has documented structural connectivity of this pathway through Re however, its functional operation is largely unexplored. Here we used

Language: Английский

The reuniens thalamus recruits recurrent excitation in the medial prefrontal cortex DOI Creative Commons
Gil Vantomme, Gabrielle Devienne, Jacob M. Hull

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(11)

Published: March 14, 2025

The medial prefrontal cortex (mPFC) and hippocampus are critical for memory retrieval, decision making, emotional regulation. While ventral CA1 (vCA1) shows direct reciprocal connections with mPFC, dorsal (dCA1) forms indirect pathways to notably via the thalamic reuniens nucleus (Re). Neuroanatomical tracing has documented structural connectivity of this pathway through Re however, its functional operation is largely unexplored. Here, we used in vivo vitro electrophysiology along optogenetics address question. Whole-cell patch-clamp recordings acute mouse brain slices revealed both monosynaptic excitatory responses disynaptic feedforward inhibition at Re–mPFC synapses. However, also identified a prolonged excitation mPFC by Re. These early late recurrent components marked contrast primarily characteristic inputs neocortex. Local field potential synaptic activity throughout all cortical lamina upon activation, enhanced blockade parvalbumin neurons GABA A Rs. In Neuropixels head-fixed awake mice similar units activation. summary, output produces within suggesting potent amplification system network. This may facilitate dCA1->mPFC signals which acts as primary conduit, there little connectivity. addition, capacity fire bursts action potentials response input suggests that these synapses have high gain.

Language: Английский

Citations

0
Mu and Delta Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms DOI Creative Commons

Rebecca H. Cole,

Max E. Joffe

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

Aberrant signaling within cortical inhibitory microcircuits has been identified as a common signature of neuropsychiatric disorders. Interneuron (IN) activity is precisely regulated by neuromodulatory systems that evoke widespread changes in synaptic transmission and principal cell output. Cortical interneurons express high levels Mu Delta opioid receptors (MOR DOR), positioning critical regulator transmission. However, we lack complete understanding how MOR DOR regulate prefrontal cortex (PFC) microcircuitry. Here, combine whole-cell patch-clamp electrophysiology, optogenetics, viral tools to provide an extensive characterization regulation We show activation more effective at suppressing spontaneous the prelimbic PFC, while causes greater acute suppression electrically-evoked GABA release. Cell type-specific optogenetics revealed differentially from parvalbumin, somatostatin, cholecystokinin, vasoactive intestinal peptide-expressing INs. Finally, demonstrate regulates through pre- postsynaptic modifications IN physiology, whereas function predominantly observed somato-dendritic or presynaptic compartments depending on type.

Language: Английский

Citations

1
Developmental maturation of frontal cortical circuits impacts decision-making DOI Open Access
Kevin Mastro, Wen-Chun Lee, Wengang Wang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 24, 2024

Abstract In humans, frontal cortical circuit maturation parallels the development of higher cognitive functions and is estimated to occur over course 15-20 years. mice, association cortex (FAC) occurs first 6-8 weeks with limited reports on changes after sexual (∼7-8 weeks). Here we characterize circuits in mice across 6 months life uncovered cell-type input-specific refinement this period, including a large increase synaptic inhibition onto pyramidal cells relative excitation. parallel, find age-related differences acquisition execution FAC-dependent probabilistic 2-armed bandit task (2-ABT). Specifically, 4–6 month-old acquire more slowly use different behavioral strategies obtain rewards compared younger mice. Lastly, show that dampening inhibitory activity FAC alters behavior manner counteracts differences. Together, these data present evidence for an extended period structural directly impacts decision-making.

Language: Английский

Citations

0
Reuniens thalamus recruits recurrent excitation in medial prefrontal cortex. DOI Creative Commons
Gil Vantomme, Gabrielle Devienne, Jacob M. Hull

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Medial prefrontal cortex (mPFC) and hippocampus are critical for memory retrieval, decision making emotional regulation. While ventral CA1 (vCA1) shows direct reciprocal connections with mPFC, dorsal (dCA1) forms indirect pathways to notably via the thalamic Reuniens nucleus (Re). Neuroanatomical tracing has documented structural connectivity of this pathway through Re however, its functional operation is largely unexplored. Here we used

Language: Английский

Citations

0