Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology

Neuron, Journal Year: 2024, Volume and Issue: 112(19), P. 3252 - 3266.e5

Published: July 29, 2024

Language: Английский

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Noninvasive targeted modulation of pain circuits with focused ultrasonic waves

Pain, Journal Year: 2024, Volume and Issue: 165(12), P. 2829 - 2839

Published: July 29, 2024

Direct interventions into deep brain circuits constitute promising treatment modalities for chronic pain. Cingulotomy and stimulation targeting the anterior cingulate cortex have shown notable improvements in unpleasantness of pain, but these require surgeries. In this study, we developed an approach that can modulate affective hub entirely noninvasively, using low-intensity transcranial-focused ultrasound. Twenty patients with pain received two 40-minute active or sham protocols were monitored one week a randomized crossover trial. Sixty percent subjects experienced clinically meaningful reduction on day 1 7 following stimulation, while provided such benefits only to 15% 20% subjects, respectively. On average, reduced by 60.0% immediately intervention 43.0% 33.0% days intervention. The corresponding levels 14.4%, 12.3%, 6.6%. was well tolerated, no adverse events detected. Side effects generally mild resolved within 24 hours. Together, direct, ultrasonic offers rapid, meaningful, durable severity.

Language: Английский

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Functional coupling between chronic pain and the autonomic nervous system revealed by neuromodulation techniques. Comment on 'Effect of neuromodulation for chronic pain on the autonomic nervous system: a systematic review' (

PubMed, Journal Year: 2025, Volume and Issue: 14, P. 100393 - 100393

Published: June 1, 2025

Language: Английский

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Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound

APL Bioengineering, Journal Year: 2025, Volume and Issue: 9(1)

Published: Feb. 19, 2025

Low-intensity transcranial focused ultrasound (tFUS) has recently been shown to noninvasively and non-pharmacologically modulate pain hypersensitivity with high spatial specificity deep brain penetration. However, the lack of knowledge about its effectiveness for management in older subjects vulnerable severe who are also at increased risk cognitive impairment, presents significant challenges. Additionally, current opioid treatments require hospital visits, limiting unwanted serious side effects multiple liabilities, device-based typically administered medical facilities bulky expensive equipment, accessibility thus highlighting need at-home non-pharmacological treatment options. Here, we present a more accessible, noninvasive tFUS strategy senior subjects. This approach involves simultaneously targeting pain-processing circuits using battery-powered, compact, low-cost analog front end (UAFE). We developed evaluated performance UAFE capable generating sufficiently high-amplitude output significantly lower noise levels compared commercial transmitter. Using humanized sickle mouse model chronic hyperalgesia, found that stimulation effectively reduces heat hyperalgesia aged female mice. In addition efficacy, our behavioral-based safety assessment revealed no adverse on motor functions. These results suggest compact target can suppress pain-related behaviors mice without negatively impacting coordination balance. highlights potential further development fully home-based seniors.

Language: Английский

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Low-intensity focused ultrasound to the posterior insula reduces temporal summation of pain

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(4), P. 911 - 924

Published: July 1, 2024

The insula and dorsal anterior cingulate cortex (dACC) are core brain regions involved in pain processing central sensitization, a shared mechanism across various chronic conditions. Methods to modulate these may serve reduce though it is unclear which target be most efficacious for different measures of sensitization.

Language: Английский

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Low-intensity focused ultrasound for human neuromodulation

Nature Reviews Methods Primers, Journal Year: 2024, Volume and Issue: 4(1)

Published: Dec. 19, 2024

Language: Английский

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Low-intensity focused ultrasound to the insula differentially modulates the heartbeat-evoked potential: a proof-of-concept study

Clinical Neurophysiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Examination of the interaction of parameters for low-intensity focused ultrasound of the human motor cortex

Brain stimulation, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Low-intensity focused ultrasound (LIFU) is a promising form of non-invasive neuromodulation characterized by rich parameter space that includes intensity, duration, duty cycle and pulsing strategy. The effect interaction these parameters to affect human brain activity poorly understood. A better understanding how interact critical advance LIFU as potential therapeutic.

Language: Английский

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Focused Ultrasound Modulates Dopamine in a Mesolimbic Reward Circuit

Journal of Neurochemistry, Journal Year: 2025, Volume and Issue: 169(2)

Published: Feb. 1, 2025

ABSTRACT Dopamine is a neurotransmitter that plays significant role in reward and motivation. Dysfunction the mesolimbic dopamine pathway has been linked to variety of psychiatric disorders, including addiction. Low‐intensity focused ultrasound (LIFU) demonstrated effects on brain activity, but how LIFU affects neurotransmission not known. Here, we applied three different intensities (6.5, 13, 26 W/cm 2 I SPPA ) 2‐min prelimbic cortex (PLC) measured nucleus accumbens (NAc) core using fast‐scan cyclic voltammetry. Two minutes sonication at 13 PLC significantly reduced release by ~50% for up h. However, double intensity (26 resulted less inhibition (~30%), half (6.5 did result any dopamine. Anatomical controls applying primary somatosensory change NAc dopamine, affect caudate or shell. Histological evaluations showed no evidence cell damage death. Modeling temperature rise demonstrates maximum 0.5°C with , suggesting modulation due thermal mechanisms. These studies show moderate provides noninvasive, high spatial resolution means modulate specific circuits could be used future target repair pathways are dysfunctional addiction other diseases. image

Language: Английский

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Advancements and prospects of transcranial focused ultrasound in pain neuromodulation

Pain, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Transcranial focused ultrasound (tFUS) is an emerging noninvasive neuromodulation technology that has shown great potential in pain modulation. This review systematically elucidates the multilevel biological mechanisms of tFUS neuromodulation, from network-wide effects to cellular and molecular processes, as well broader systemic influences. Preliminary animal model studies have revealed tFUS's ability improve behavioral indicators modulate neural circuit activity under pathological conditions. A small number clinical also suggest may certain benefits improving symptom experience emotional state chronic patients. However, current research generally limitations such sample sizes short follow-up periods. More high-quality are needed verify long-term safety treatment. Overcoming these advancing large-scale translational will help fully exploit application precision medicine provide new treatment options for relief.

Language: Английский

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