Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice DOI Creative Commons
Evan D. Vickers, David A. McCormick

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 23, 2023

The flow of neural activity across the neocortex during active sensory discrimination is constrained by task-specific cognitive demands, movements, and internal states. During behavior, brain appears to sample from a broad repertoire activation motifs. Understanding how these patterns local global are selected in relation both spontaneous task-dependent behavior requires in-depth study densely sampled at single neuron resolution large regions cortex. In significant advance toward this goal, we developed procedures record mesoscale 2-photon Ca

Language: Английский

Detection and neural encoding of whisker-generated sounds in mice DOI

B.G. Efron,

Athanasios Ntelezos,

Yonatan Katz

et al.

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Stimulus-Specific Prediction Error Neurons in Mouse Auditory Cortex DOI Creative Commons
Nicholas J. Audette, David M. Schneider

Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 43(43), P. 7119 - 7129

Published: Sept. 12, 2023

Comparing expectation with experience is an important neural computation performed throughout the brain and a hallmark of predictive processing. Experiments that alter sensory outcome animal's behavior reveal enhanced responses to unexpected self-generated stimuli, indicating populations neurons in cortex may reflect prediction errors (PEs), mismatches between experience. However, stimuli could also arise through nonpredictive mechanisms, such as movement-based facilitation neuron's inherent sound responses. If error exist cortex, it unknown whether they manifest general responses, or respond specificity distinct stimulus dimensions. To answer these questions, we trained mice either sex expect simple sound-generating recorded auditory activity heard expected sounds deviated from one multiple Our data learns suppress along acoustic dimensions simultaneously. We identify population are not responsive passive but encode errors. These abundant only animals learned motor-sensory expectation, two specific violations rather than generic signal. Together, findings cortical predictions about have simultaneous expectation.

Language: Английский

Citations

20
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice DOI Creative Commons
Evan D. Vickers, David A. McCormick

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 23, 2024

The flow of neural activity across the neocortex during active sensory discrimination is constrained by task-specific cognitive demands, movements, and internal states. During behavior, brain appears to sample from a broad repertoire activation motifs. Understanding how these patterns local global are selected in relation both spontaneous task-dependent behavior requires in-depth study densely sampled at single neuron resolution large regions cortex. In significant advance toward this goal, we developed procedures record mesoscale 2-photon Ca2+ imaging data two novel vivo preparations that, between them, allow for simultaneous access nearly all 0f mouse dorsal lateral neocortex. As proof principle, aligned with behavioral primitives high-level motifs reveal existence populations neurons that coordinated their cortical areas changes movement and/or arousal. methods detail here facilitate identification exploration widespread, spatially heterogeneous ensembles whose related diverse aspects behavior.

Language: Английский

Citations

3
Reliable sensory processing of superficial cortical interneurons is modulated by behavioral state DOI Creative Commons
Carolyn G. Sweeney, Maryse E. Thomas, Christine Liu

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(5), P. 115678 - 115678

Published: May 1, 2025

Language: Английский

Citations

0
Sensation and expectation are embedded in mouse motor cortical activity DOI Creative Commons
Brooke E. Holey, David M. Schneider

Cell Reports, Journal Year: 2024, Volume and Issue: 43(7), P. 114396 - 114396

Published: June 25, 2024

During behavior, the motor cortex sends copies of motor-related signals to sensory cortices. Here, we combine closed-loop behavior with large-scale physiology, projection-pattern-specific recordings, and circuit perturbations show that neurons in mouse secondary (M2) encode sensation are influenced by expectation. When a movement unexpectedly produces sound, M2 becomes dominated sound-evoked activity. Sound responses inherited partially from auditory routed back cortex, providing path for reciprocal exchange sensory-motor information during behavior. acoustic consequences become predictable, self-generated sounds selectively gated off. These changes single-cell reflected population dynamics, which both Together, these findings reveal embedding expectation cortical

Language: Английский

Citations

1
Vocalization modulates the mouse auditory cortex even in the absence of hearing DOI Creative Commons
Thomas C. Harmon, Seth Madlon‐Kay, John Pearson

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(8), P. 114611 - 114611

Published: Aug. 1, 2024

Vocal communication depends on distinguishing self-generated vocalizations from other sounds. motor corollary discharge (CD) signals are thought to support this ability by adaptively suppressing auditory cortical responses feedback. One challenge is that vocalizations, especially those produced during courtship and social interactions, accompanied movements emitted a state of heightened arousal, factors could potentially modulate activity. Here, we monitor activity, ultrasonic (USVs), non-vocal behaviors in head-fixed male mouse while he interacts with female mouse. This approach reveals vocalization-specific signature the cortex suppresses activity USV playback-excited neurons, emerges before vocal onset, scales band power. Notably, modulatory also present congenitally deaf mice, revealing an adaptive CD signal manifests independently feedback or experience.

Language: Английский

Citations

1
Experience-driven development of decision-related representations in the auditory cortex DOI Creative Commons

Itay Kazanovich,

Shir Itzhak,

Jennifer Resnik

et al.

EMBO Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Language: Английский

Citations

1
Sensation and expectation are embedded in mouse motor cortical activity DOI Creative Commons
Brooke E. Holey, David M. Schneider

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 14, 2023

During behavior, the motor cortex sends copies of motor-related signals to sensory cortices. It remains unclear whether these corollary discharge strictly encode movement or they also experience and expectation. Here, we combine closed-loop behavior with large-scale physiology, projection-pattern specific recordings, circuit perturbations show that neurons in mouse secondary (M2) sensation are influenced by When a unexpectedly produces sound, M2 becomes dominated sound-evoked activity. Sound responses inherited partially from auditory routed back cortex, providing path for dynamic exchange sensory-motor information during behavior. acoustic consequences become predictable, self-generated sounds selectively gated off. These changes single-cell reflected population dynamics, which both Together, findings reveal rich embedding expectation cortical

Language: Английский

Citations

3
Auditory discrimination learning differentially modulates neural representation in auditory cortex subregions and inter-areal connectivity DOI Creative Commons
Mingxuan Wang, Peter Jendrichovsky, Patrick O. Kanold

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(5), P. 114172 - 114172

Published: May 1, 2024

Language: Английский

Citations

0
Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice DOI Creative Commons
Evan D. Vickers, David A. McCormick

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 23, 2023

The flow of neural activity across the neocortex during active sensory discrimination is constrained by task-specific cognitive demands, movements, and internal states. During behavior, brain appears to sample from a broad repertoire activation motifs. Understanding how these patterns local global are selected in relation both spontaneous task-dependent behavior requires in-depth study densely sampled at single neuron resolution large regions cortex. In significant advance toward this goal, we developed procedures record mesoscale 2-photon Ca

Language: Английский

Citations

1