Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(6), P. e3001275 - e3001275

Published: June 2, 2021

Episodic memory depends on interactions between the hippocampus and interconnected neocortical regions. Here, using data-driven analyses of resting-state functional magnetic resonance imaging (fMRI) data, we identified networks that interact with hippocampus-the default mode network (DMN) a "medial temporal network" (MTN) included regions in medial lobe (MTL) precuneus. We observed MTN plays critical role connecting visual to DMN hippocampus. The could be further divided into 3 subnetworks: "posterior medial" (PM) subnetwork comprised posterior cingulate lateral parietal cortices; an "anterior temporal" (AT) temporopolar dorsomedial prefrontal cortex; prefrontal" (MP) primarily cortex (mPFC). These vary their connectivity (FC) along hippocampal long axis represent different kinds information during memory-guided decision-making. Finally, Neurosynth meta-analysis fMRI studies suggests new hypotheses regarding functions subnetworks, providing framework guide future research neural architecture episodic memory.

Language: Английский

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Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(7), P. 2161 - 2169

Published: March 7, 2024

Abstract Trauma-related intrusive memories (TR-IMs) possess unique phenomenological properties that contribute to adverse post-traumatic outcomes, positioning them as critical intervention targets. However, transdiagnostic treatments for TR-IMs are scarce, their underlying mechanisms have been investigated separate from properties. Extant models of more general episodic memory highlight dynamic hippocampal-cortical interactions vary along the anterior-posterior axis hippocampus (HPC) support different cognitive-affective and sensory-perceptual features memory. Extending this work into TR-IMs, we conducted a study eighty-four trauma-exposed adults who completed daily ecological momentary assessments TR-IM followed by resting-state functional magnetic resonance imaging (rs-fMRI). Spatiotemporal dynamics anterior posterior hippocampal (a/pHPC)-cortical networks were assessed using co-activation pattern analysis investigate associations with TR-IMs. Emotional intensity was inversely associated frequency persistence an aHPC-default mode network pattern. Conversely, sensory frequent HPC cortices ventral attention network, reliving in “here-and-now” persistent pHPC visual cortex. Notably, no found between HPC-cortical conventional symptom measures, including or retrospective recall, underscoring utility identifying neural substrates. These findings provide novel insights correlates development individualized, pervasive, difficult-to-treat symptom.

Language: Английский

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Emotion in the mind's eye: Imagination for adaptive cognition

Annals of the New York Academy of Sciences, Journal Year: 2023, Volume and Issue: 1526(1), P. 59 - 72

Published: June 21, 2023

Abstract In a complex world, we are constantly faced with environmental stimuli that shape our moment‐to‐moment experiences. But just as rich and the external world is internal milieu—our imagination. Imagination offers powerful vehicle for playing out hypothetical experiences in mind's eye. It allows us to mentally time travel behold what future might bring, including greatest desires or fears. Indeed, imagined tend be emotion‐laden. How why humans capable of this remarkable feat? Based on psychological findings, highlight importance imagination emotional aspects cognition behavior, namely generation regulation emotions. recent cognitive neuroscience work, identify putative neural networks most critical imagination, major focus default mode network. Finally, briefly possible functional implications individual differences Overall, hope address have capacity simulate how ability can harnessed adaptive (and sometimes maladaptive) ways. We end by discussing open questions.

Language: Английский

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Neural specialisation for concrete and abstract concepts revealed through meta-analysis

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 16, 2024

Abstract Identifying the brain regions that process concrete and abstract concepts is key to understanding neural architecture of thought, memory language. We review current theories concreteness effects test their predictions in a meta-analysis 72 neuroimaging studies (1400 participants). Concrete preferentially activated visual action processing regions, particularly when presented sentences. networks for social cognition (particularly sentences), language semantic control as single words). These results suggest vary both information-processing modalities they engage demands place on cognitive processes. Specialisation concept types was present different parts default mode network (DMN), with dissociating along social-spatial axis. generated greater activation medial temporal DMN component, implicated constructing mental models spatial contexts scenes. In contrast, showed frontotemporal involved theory-of-mind processing. support prior claims generating situations events core function further indicate specialisation within aspects these models. Public significance statement The distinction between fundamental cognition. Here, we largest experiments investigating this distinction, including data from 1400 participants. Our differentially engages range systems perception, action, provide new insights into how constructs representations world linguistic information, basis imagination.

Language: Английский

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A Pharmacotherapeutic and Neuroimaging Case Study of Maladaptive Daydreaming

Psychiatry Research Case Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100249 - 100249

Published: Jan. 1, 2025

Language: Английский

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Narrative imagery: Emotional modulation in the default mode network

Neuropsychologia, Journal Year: 2021, Volume and Issue: 164, P. 108087 - 108087

Published: Nov. 14, 2021

Language: Английский

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Resting state functional connectivity in dependent cannabis users: The moderating role of cannabis attitudes

Drug and Alcohol Dependence, Journal Year: 2024, Volume and Issue: 256, P. 111090 - 111090

Published: Jan. 15, 2024

The global increase in lenient cannabis policy has been paralleled by reduced harm perception, which associated with use initiation and persistent use. However, it is unclear how attitudes might affect the brain processes underlying Resting state functional connectivity (RSFC) within between executive control network (ECN), salience (SN), default mode (DMN) was assessed 110 near-daily users disorder (CUD) 79 controls from Netherlands Texas, USA. Participants completed a questionnaire assessing perceived benefits harms of their personal, friends-family's, country-state's perspectives reported on (gram/week), CUD severity, cannabis-related problems. RSFC dorsal SN lower than controls, while no group differences between-network were observed. Furthermore, heavier group. Perceived – moderated associations use, use-related problems within-network SN, ECN, DMN. Personal country-state association severity ventral This study highlights importance considering individual as factor functioning

Language: Английский

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Triple Network Functional Connectivity During Acute Stress in Adolescents and the Influence of Polyvictimization

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2022, Volume and Issue: 7(9), P. 867 - 875

Published: March 12, 2022

Exposure to both chronic and acute stressors can disrupt functional connectivity (FC) of the default mode network (DMN), salience (SN), central executive (CEN), increasing risk for negative health outcomes. During adolescence, these stress-sensitive triple networks undergo critical neuromaturation that is altered by exposure general forms trauma or victimization. However, no work has directly examined how stress affects FC in adolescents whether polyvictimization-exposure multiple categories/subtypes victimization-influences adolescent neural response.This magnetic resonance imaging study seed-to-voxel DMN, SN, CEN during Montreal Imaging Stress Task. Complete data from 73 participants aged 9 16 years (31 female) are reported.During stress, was increased between DMN regions decreased SN CEN. Greater polyvictimization associated with reduced seed a cluster containing left insula SN.These results indicate alters adolescents. In addition, changes further moderated exposure.

Language: Английский

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Functional specialization of parallel distributed networks revealed by analysis of trial-to-trial variation in processing demands

Journal of Neurophysiology, Journal Year: 2022, Volume and Issue: 129(1), P. 17 - 40

Published: Oct. 5, 2022

Multiple large-scale networks populate human association cortex. Here, we explored the functional properties of these by exploiting trial-to-trial variation in component-processing demands. In two behavioral studies (n = 136 and n 238), participants quantified strategies used to solve individual task trials that spanned remembering, imagining future scenarios, various control trials. These were also all scanned an independent sample MRI 10), each with sufficient data precisely define within-individual networks. Stable latent factors varied across correlated trial-level responses selectively One network linked parahippocampal cortex, labeled Default Network A (DN-A), tracked scene construction, including for possessed minimal episodic memory To degree, a trial encouraged construct mental imagery awareness about spatial locations objects or places, response DN-A increased. The juxtaposed B (DN-B) showed no such but relation social processing Another adjacent network, Frontoparietal (FPN-B), robustly difficulty. results support DN-B are specialized differentially supporting information within domains. Both dissociable from closely domain-general tracks cognitive effort.NEW & NOTEWORTHY Tasks shown recruit parallel multifaceted, leaving open questions processes. examining traits reveals new insights into functions. particular, processes construction distributed links retrosplenial cortices, during designed not rely on personal past. Adjacent show distinct patterns, providing novel evidence specialization.

Language: Английский

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A neural signature of the vividness of prospective thought is modulated by temporal proximity during intertemporal decision making

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(44)

Published: Oct. 24, 2022

Why do people discount future rewards? Multiple theories in psychology argue that one reason is events are imagined less vividly than immediate events, thereby diminishing their perceived value. Here we provide neuroscientific evidence for this proposal. First, construct a neural signature of the vividness prospective thought, using an fMRI dataset where orthogonal to valence by design. Then, apply two additional datasets, each different delay-discounting task, show measures decline as rewards delayed farther into future.

Language: Английский

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