Structural Disconnections Caused by White Matter Hyperintensities in Post‐Stroke Spatial Neglect DOI Creative Commons
Lisa Röhrig, Hans‐Otto Karnath

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(17)

Published: Nov. 25, 2024

ABSTRACT White matter hyperintensities (WMH), a common feature of cerebral small vessel disease, affect wide range cognitive dysfunctions, including spatial neglect. The latter is disorder attention and exploration typically after right hemisphere brain damage. To explore the impact WMH on neglect‐related structural disconnections, present study investigated indirectly quantified disconnectome induced by either stroke lesion alone, or their combination. Furthermore, we compared different measures disconnection—voxel‐wise, pairwise, tract‐wise, parcel‐wise—to identify neural correlates predict acute neglect severity. We observed that WMH‐derived disconnections alone were not associated with behavior. However, when combined derived from individual lesions, pre‐stroke contributed to post‐stroke severity affecting frontal subcortical substrates, like middle gyrus, basal ganglia, thalamus, fronto‐pontine tract. Predictive modeling demonstrated voxel‐wise disconnection data outperformed other disconnection, explaining 42% total variance; interestingly, best model used predictors stroke‐based only. conclude prestroke alterations in white microstructure due contribute poststroke deficits attention, likely impairing integrity human networks.

Language: Английский

ARPA: Augmented Reality Prism Adaptation induces sensorimotor and visuospatial effects DOI
Ivan Patané,

Julie Bui,

Flimmy Agon

et al.

Neuropsychological Rehabilitation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: April 21, 2025

Prism adaptation (PA) is a well-established method for sensorimotor recalibration and influencing visuospatial processing. It also one of the rehabilitation approaches neglect patients. Recent studies have shown effective in virtual reality (VR) settings simulating classic PA procedure. However, no research has explored prism augmented (AR), which combines advantages VR with greater ecological validity, allowing individuals to perform procedure real environment natural visual feedback from their own hand. The present study introduces Augmented Reality Adaptation (ARPA), novel that incorporates benefits AR technique. Forty-eight healthy participants underwent either leftward or rightward ARPA, aftereffects were evaluated immediately post-ARPA over 40-minute period. Results revealed significant long-lasting following both while only ARPA induced an immediate aftereffect. Importantly, we investigated generalization these changes environment, finding ARPA-induced extended beyond setting. While findings show produces aftereffects, further essential evaluate its applicability effectiveness rehabilitation.

Language: Английский

Citations

0
Incidence of Visuospatial Neglect in Acute Stroke: Assessment and Stroke Characteristics in an Unselected 1-Year Cohort DOI
Dario Cazzoli, Brigitte C. Kaufmann, Henrik Rühe

et al.

Stroke, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

BACKGROUND: The true incidence of visuospatial neglect, impaired attention toward contralesional space, remains unclear. Common variability sources are sensitivity differences conventional assessments and the exclusion patients with language, motor, other cognitive impairments. We aimed to determine neglect in an unselected cohort acute stroke using video oculography during free visual exploration, a newly established assessment overcoming aforementioned biases. METHODS: Single-center, prospective, observational study. screened every patient admitted representative Swiss center over 1 year (n=626). Two hundred eighty-five were eligible (first-ever within 72 hours), 221 included. was determined paper-pencil exploration. Demographic, risk, stroke-related factors, as well localization, also considered. Feasibility ability detect evaluated. RESULTS: overall ≈38%: widely varying location-specifically: ≈61% ≈22% for right left cerebral hemispheres, respectively, ≈14% ≈37% some less commonly affected infratentorial areas or multifocal stroke. In hemispheric stroke, most common when middle (≈64% ≈21% left) posterior (≈53% ≈25% artery territories affected. Neglect had higher National Institutes Health Stroke Scale scores, more atrial fibrillation thrombectomy, undetermined cause. They older, ≈4% yearly increase odds having neglect. Video exploration administrable detected often than assessments. CONCLUSIONS: cohort, highly sensitive assessment, is considerably previously assumed can occur after typically localized strokes. These results enhance awareness setting, potentially facilitating earlier identification therapy this disabling disorder.

Language: Английский

Citations

0
Unveiling Spatial and Non-Spatial Aspects of Neglect in Everyday Behavior DOI
Brigitte C. Kaufmann, Paolo Bartolomeo, Monica N. Toba

et al.

Cortex, Journal Year: 2024, Volume and Issue: 182, P. 208 - 211

Published: Oct. 22, 2024

Language: Английский

Citations

2
Structural Disconnections Caused by White Matter Hyperintensities in Post‐Stroke Spatial Neglect DOI Creative Commons
Lisa Röhrig, Hans‐Otto Karnath

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(17)

Published: Nov. 25, 2024

ABSTRACT White matter hyperintensities (WMH), a common feature of cerebral small vessel disease, affect wide range cognitive dysfunctions, including spatial neglect. The latter is disorder attention and exploration typically after right hemisphere brain damage. To explore the impact WMH on neglect‐related structural disconnections, present study investigated indirectly quantified disconnectome induced by either stroke lesion alone, or their combination. Furthermore, we compared different measures disconnection—voxel‐wise, pairwise, tract‐wise, parcel‐wise—to identify neural correlates predict acute neglect severity. We observed that WMH‐derived disconnections alone were not associated with behavior. However, when combined derived from individual lesions, pre‐stroke contributed to post‐stroke severity affecting frontal subcortical substrates, like middle gyrus, basal ganglia, thalamus, fronto‐pontine tract. Predictive modeling demonstrated voxel‐wise disconnection data outperformed other disconnection, explaining 42% total variance; interestingly, best model used predictors stroke‐based only. conclude prestroke alterations in white microstructure due contribute poststroke deficits attention, likely impairing integrity human networks.

Language: Английский

Citations

0