Rohon-beard neurons do not succumb to programmed cell death during zebrafish development
Developmental Biology,
Journal Year:
2024,
Volume and Issue:
515, P. 186 - 198
Published: June 27, 2024
Language: Английский
Fishing Innate Immune System Properties through the Transcriptomic Single-Cell Data of Teleostei
Biology,
Journal Year:
2023,
Volume and Issue:
12(12), P. 1516 - 1516
Published: Dec. 12, 2023
The
innate
immune
system
is
the
first
line
of
defense
in
multicellular
organisms.
Language: Английский
Caliber of sensory axons in vivo varies spatially and temporally and is influenced by the cellular microenvironment
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Abstract
Cell
shape
is
crucial
to
cell
function,
particularly
in
neurons.
The
cross-sectional
diameter,
also
known
as
caliber,
of
axons
and
dendrites
an
important
parameter
neuron
shape,
best
appreciated
for
its
influence
on
the
speed
action
potential
propagation.
Most
studies
axon
caliber
focus
cell-wide
regulation
assume
that
static.
Here,
we
have
investigated
local
variation
dynamics
peripheral
zebrafish
touch-sensing
neurons
at
embryonic
stages,
prior
sex
determination.
To
obtain
absolute
measurements
vivo,
paired
sparse
membrane
labeling
with
super-resolution
microscopy
live
fish.
We
found
segments
had
varicose
or
“pearled”
morphologies,
thus
vary
along
their
length,
consistent
reports
from
mammalian
systems.
Sister
originating
most
proximal
branch
point
arbor
average
calibers
were
largely
independent
each
other.
Axon
tapered
across
point,
suggesting
conductance
may
be
favored
these
afferent
axons.
Caliber
was
dynamic
time-scale
minutes,
this
dynamicity
changed
over
course
development.
By
measuring
adjacent
dividing
epithelial
cells,
cellular
microenvironment
one
potentially
multiple
drivers
space
time.
Our
findings
raise
possibility
spatial
temporal
could
significantly
neuronal
physiology.
Significance
Statement
directly
influences
how
quickly
send
messages
other
cells
likely
plays
a
role
overall
health
In
nervous
system,
where
cover
long
distances,
can
determine
whether
animal
successfully
executes
behaviors
such
escape
response.
between
locations
within
same
cell,
it
highly
dynamic.
Taking
variations
into
account
allow
neuroscientists
better
estimate
transmission
speeds
neural
circuits.
Additionally,
distorted
when
nearby
change
shape.
Thus,
many
contributors
dynamics,
broadening
our
view
determinants.
Language: Английский
Complete persistence of the primary somatosensory system in zebrafish
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 19, 2023
Abstract
The
somatosensory
system
detects
peripheral
stimuli
that
are
translated
into
behaviors
necessary
for
survival.
Fishes
and
amphibians
possess
two
systems
in
the
trunk:
primary
system,
formed
by
Rohon-Beard
neurons,
secondary
neural
crest
cell-derived
neurons
of
Dorsal
Root
Ganglia.
have
been
characterized
as
a
transient
population
mostly
disappears
during
first
days
life
is
functionally
replaced
Here,
I
comprehensively
follow
vivo
show
entire
repertoire
remains
present
zebrafish
from
1-day
post-fertilization
until
juvenile
stage,
15-days
post-fertilization.
These
data
indicate
retain
complete
at
least
up
to
developmental
stage
when
animals
display
complex
behavioral
repertoires.
Language: Английский