Regulation of critical brain dynamics and its functional implications DOI Creative Commons
Arthur-Ervin Avrămiea

Published: Feb. 1, 2023

Evidence of criticality at various levels neuronal organization has accumulated over the past 2 decades. However, little is known how affects brain function, whether critical state always optimal for information processing, and can change its operating point with regards to so as accommodate varying processing requirements. Therefore, aim this thesis elucidate mechanisms that regulate understand their impact on local global processing. We empirically validated control level via neuromodulation, implications perception. Then, we relied computational modeling gain full parameters determine criticality, tested two theories function. Last, since excitation/inhibition balance be a crucial determinant which vary across individuals, but also within subjects time developed method non-invasively estimate functional E/I ratio.

Language: Английский

A dynamic link between respiration and arousal DOI
Daniel S. Kluger, Joachim Groß, Christian Keitel

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 44(47), P. e1173242024 - e1173242024

Published: Oct. 8, 2024

Viewing brain function through the lens of other physiological processes has critically added to our understanding human cognition. Further advances though may need a closer look at interactions between these themselves. Here we characterize interplay highly periodic, and metabolically vital respiratory process fluctuations in arousal neuromodulation, classically seen as nonperiodic. In data from three experiments ( N = 56 / 27 25 women men), tested for covariations pupil size (arousal) dynamics. After substantiating robust coupling largest dataset, further show that strength decreases during task performance compared with rest it mirrors decreased rate when participants take deeper breaths. Taken together, findings suggest stronger link than previously thought. Moreover, links imply periods rest, effect on suggests driving role. As consequence, studying role neuromodulatory cortical also consider influences.

Language: Английский

Citations

3
Spectral Fingerprints of Cortical Neuromodulation DOI Creative Commons
Angela Radetz, Markus Siegel

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 42(18), P. 3836 - 3846

Published: March 31, 2022

Pupil size has been established as a versatile marker of noradrenergic and cholinergic neuromodulation, which profound effects on neuronal processing, cognition, behavior. However, little is known about the cortical control pupil-linked neuromodulation. Here, we show that pupil dynamics are tightly coupled to temporally, spectrally, spatially specific modulations local large-scale population activity in human brain. We quantified band-limited resting subjects using magnetoencephalography investigated how neural were linked simultaneously recorded dynamics. Our results neuromodulation does not merely affect stereotypical fashion. Instead, identified three frontal, precentral, occipitoparietal networks, with distinct spectral profiles theta, beta, alpha bands temporally preceded followed changes size. Furthermore, found amplitude coupling at ∼16 Hz frontoparietal network predicted unravel network-specific fingerprints brain likely reflect both causes SIGNIFICANCE STATEMENT Brain function constantly affected by modulatory neurotransmitters. because correlates largely unknown, fundamental questions remain unresolved. Which networks neuromodulation? Does or region-specific fashion? To address this, magnetoencephalography. highly four These effect

Language: Английский

Citations

8
Spectral waveform analysis dissociates human cortical alpha rhythms DOI Creative Commons

Janet Giehl,

Markus Siegel

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 17, 2024

The non-sinusoidal waveform of neuronal oscillations reflects the physiological properties underlying circuit interactions and may serve as an informative biomarker healthy diseased human brain function. However, little is known about which rhythms can be dissociated based on their methods to comprehensively characterize waveforms are missing. Here, we introduce a novel spectral analysis (SWA) that provides complete description, noise-resistant, allows reconstruct time-domain waveforms. We applied this framework magnetoencephalography (MEG) recordings during rest identified several distinct previously unknown cortical alpha were temporally stable specific for individual subjects. Our findings suggest at least four in sensorimotor, occipital, temporal, parietal cortex. SWA powerful new neural brain.

Language: Английский

Citations

1
Blink-induced changes in pupil dynamics are consistent and heritable DOI Creative Commons
Şükrü Barış Demiral, Nora D. Volkow

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 18, 2024

Abstract Pupil size and blink rates are heritable but the extent to which they interact with one another has not been properly investigated. Though changes in pupil due eye blinks have reported, considered a pupillary artifact. In this study we used HCP 7T fMRI dataset resting state eye-tracking data obtained monozygotic dizygotic twins assess their heritability interactions. For purpose, characterized dilation (positive peak) constriction (negative that followed events, describe as blink-induced response (BIPR). We show BIPR is highly consistent positive dilatory peak (D-peak) around 500ms negative constricting (C-peak) 1s. These patterns were reproducible within- between-subjects across two time points differed by vigilance (vigilant versus drowsy). By comparing between component significant additive genetic (A) environmental (E) factors dominating structural equation models, particularly time-domain for both D- C-peaks (a 2 42 49%) shared effects (C) observed amplitude domain C-peak. Blink duration, rate also found be up 62% size). Our provides evidence of influence indicates should treated coincidental artefact. Instead appears larger oculomotor system label here Oculomotor Adaptive System, genetically determined.

Language: Английский

Citations

1
A dynamic link between respiration and arousal DOI Creative Commons
Daniel S. Kluger, Joachim Groß, Christian Keitel

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 7, 2023

Abstract Viewing brain function through the lense of other physiological processes has critically added to our understanding human cognition. Further advances though may need a closer look at interactions between these themselves. Here we characterise interplay highly periodic, and metabolically vital respiratory process fluctuations in arousal neuromodulation, classically seen as non-periodic. In data three experiments (N = 56 / 27 25) tested for covariations pupil size (arousal) dynamics. After substantiating robust coupling largest dataset, further show that strength decreases during task performance compared with rest, it mirrors decreased rate when participants take deeper breaths. Taken together, findings suggest stronger link than previously thought. Moreover, links imply periods effect on suggests driving role. As consequence, studying role neuromodulatory cortical also consider influences.

Language: Английский

Citations

3
Pupillary response to percutaneous auricular vagus nerve stimulation in alcohol withdrawal syndrome: A pilot trial DOI Creative Commons
Michael Treiber,

J Grünberger,

Benjamin Vyssoki

et al.

Alcohol, Journal Year: 2023, Volume and Issue: 114, P. 61 - 68

Published: Sept. 2, 2023

Autonomic symptoms in alcohol withdrawal syndrome (AWS) are associated with a sympathetic-driven imbalance of the autonomic nervous system. To restore balance AWS, novel neuromodulatory approaches could be beneficial. We conducted pilot trial percutaneous auricular vagus nerve stimulation (pVNS) AWS and hypothesized that pVNS will enhance parasympathetic tone represented by reduction pupillary dilation parasympatholytic pharmacological challenge.

Language: Английский

Citations

2
Blink-induced changes in pupil dynamics are consistent and heritable DOI Creative Commons
Şükrü Barış Demiral, Nora D. Volkow

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Pupil size and blink rates are heritable but the extent to which they interact with one another has not been properly investigated. Though changes in pupil due eye blinks have reported, considered a pupillary artifact. In this study we used HCP 7T fMRI dataset resting state eye-tracking data obtained monozygous dizygous twins assess their heritability interactions. For purpose, characterized dilation (positive peak) constriction (negative that followed events, describe as blink-induced response (BIPR). We show BIPR is highly consistent positive dilatory peak (D-peak) around 500ms negative constricting (C-peak) 1s. These patterns were reproducible within- between- subjects across two time points differed by vigilance (vigilant versus drowsy). By comparing between component significant additive genetic (A) environmental (E) factors dominating structural equation models, particularly time-domain for both D- C-peaks amplitude domain C-peak. (a

Language: Английский

Citations

0
Regulation of critical brain dynamics and its functional implications DOI Creative Commons
Arthur-Ervin Avrămiea

Published: Feb. 1, 2023

Evidence of criticality at various levels neuronal organization has accumulated over the past 2 decades. However, little is known how affects brain function, whether critical state always optimal for information processing, and can change its operating point with regards to so as accommodate varying processing requirements. Therefore, aim this thesis elucidate mechanisms that regulate understand their impact on local global processing. We empirically validated control level via neuromodulation, implications perception. Then, we relied computational modeling gain full parameters determine criticality, tested two theories function. Last, since excitation/inhibition balance be a crucial determinant which vary across individuals, but also within subjects time developed method non-invasively estimate functional E/I ratio.

Language: Английский

Citations

0