Metabolic reprogramming during neuronal differentiation DOI Creative Commons
Massimiliano Agostini, Francesco Romeo, Satoshi Inoue

et al.

Cell Death and Differentiation, Journal Year: 2016, Volume and Issue: 23(9), P. 1502 - 1514

Published: April 8, 2016

Newly generated neurons pass through a series of well-defined developmental stages, which allow them to integrate into existing neuronal circuits. After exit from the cell cycle, postmitotic undergo migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation plasticity. Lack global metabolic analysis during early cortical development led us explore role cellular metabolism mitochondrial biology ex vivo differentiation primary neurons. Unexpectedly, we observed huge increase in biogenesis. Changes mass, morphology function were correlated with upregulation master regulators biogenesis, TFAM PGC-1α. Concomitant an glucose differentiation, was linked uptake enhanced GLUT3 mRNA expression platelet isoform phosphofructokinase 1 (PFKp) protein expression. In addition, glutamate-glutamine also increased We identified PI3K-Akt-mTOR signalling as critical regulator energy Selective pharmacological inhibition these pathways indicate existence checkpoint that need be satisfied order differentiation.

Language: Английский

Synaptic changes in Alzheimer’s disease and its models DOI

Julio Pozueta,

Roger Lefort, Michael L. Shelanski

et al.

Neuroscience, Journal Year: 2012, Volume and Issue: 251, P. 51 - 65

Published: June 9, 2012

Language: Английский

Citations

267
Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models DOI
Verónica Martínez‐Cerdeño

Developmental Neurobiology, Journal Year: 2016, Volume and Issue: 77(4), P. 393 - 404

Published: July 8, 2016

Dendrites and spines are the main neuronal structures receiving input from other neurons glial cells. Dendritic spine number, size, morphology some of crucial factors determining how signals coming individual synapses integrated. Much remains to be understood about characteristics dendrites dendritic in autism related disorders. Although there have been many studies conducted using mouse models, few carried out postmortem human tissue patients. Available animal models include those generated through genetic modifications non-genetic disease. Here, we review dendrite number is affected neurodevelopmental diseases, both human, autism. Overall, data obtained point a generalized reduction size as well an alteration dendrites; increase densities with immature morphology, indicating general immaturity state Additional on needed understand properties these cerebral cortex patients © 2016 Wiley Periodicals, Inc. Develop Neurobiol 77: 419-437, 2017.

Language: Английский

Citations

230
Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets DOI
Komal Thapa, Heena Khan, Thakur Gurjeet Singh

et al.

Journal of Molecular Neuroscience, Journal Year: 2021, Volume and Issue: 71(9), P. 1725 - 1742

Published: May 6, 2021

Language: Английский

Citations

216
Intellectual disability and autism spectrum disorders: Causal genes and molecular mechanisms DOI
Anand K. Srivastava, Charles E. Schwartz

Neuroscience & Biobehavioral Reviews, Journal Year: 2014, Volume and Issue: 46, P. 161 - 174

Published: April 4, 2014

Language: Английский

Citations

215
Metabolic reprogramming during neuronal differentiation DOI Creative Commons
Massimiliano Agostini, Francesco Romeo, Satoshi Inoue

et al.

Cell Death and Differentiation, Journal Year: 2016, Volume and Issue: 23(9), P. 1502 - 1514

Published: April 8, 2016

Newly generated neurons pass through a series of well-defined developmental stages, which allow them to integrate into existing neuronal circuits. After exit from the cell cycle, postmitotic undergo migration, axonal elongation, axon pruning, dendrite morphogenesis and synaptic maturation plasticity. Lack global metabolic analysis during early cortical development led us explore role cellular metabolism mitochondrial biology ex vivo differentiation primary neurons. Unexpectedly, we observed huge increase in biogenesis. Changes mass, morphology function were correlated with upregulation master regulators biogenesis, TFAM PGC-1α. Concomitant an glucose differentiation, was linked uptake enhanced GLUT3 mRNA expression platelet isoform phosphofructokinase 1 (PFKp) protein expression. In addition, glutamate-glutamine also increased We identified PI3K-Akt-mTOR signalling as critical regulator energy Selective pharmacological inhibition these pathways indicate existence checkpoint that need be satisfied order differentiation.

Language: Английский

Citations

213