American Journal of Psychiatry, Journal Year: 2020, Volume and Issue: 177(7), P. 601 - 610

Published: March 12, 2020

Objective: Anorexia nervosa has the highest mortality rate of any psychiatric condition, yet pathophysiology this disorder and its primary symptom, extreme dietary restriction, remains poorly understood. In states hunger relative to satiety, rewarding value food stimuli normally increases promote eating, individuals with anorexia avoid despite emaciation. This study’s aim was examine potential neural insensitivity these effects in nervosa. Methods: At two scanning sessions scheduled 24 hours apart, one after a 16-hour fast standardized meal, 26 women who were remission from (to confounding malnutrition) 22 matched control received tastes sucrose solution or ionic water while functional MRI data acquired. Within network interest responsible for valuation transforming taste signals into motivation eat, authors compared groups across conditions on blood-oxygen-level-dependent (BOLD) signal task-based connectivity. Results: Participants had similar BOLD responses tastants. A group-by-condition interaction ventral caudal putamen indicated that opposite tastant response group remitted group, an increase decrease, respectively, when hungry. Hunger effect insula-to-ventral connectivity group. Exploratory analyses lower caudate tastants hungry associated higher scores harm avoidance among participants Conclusions: Reduced recruitment circuitry translates stimulation motivated eating behavior may facilitate prolonged periods extremely restricted intake

Language: Английский