New Directions for Epigenetics: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research DOI
Toshitsugu Fujita, Hodaka Fujii

Elsevier eBooks, Journal Year: 2022, Volume and Issue: unknown, P. 843 - 868

Published: Sept. 16, 2022

Language: Английский

DNA Repair Factors Involved in Class Switch Recombination DOI

Philip Barbulescu,

Alberto Martín

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Error-Prone DNA Mismatch and Base Excision Repair in the Somatic Hypermutation of Antibody Variable Regions DOI
Shoeb Ikhlas, Karla Cervantes-Gracia, Matthew D. Scharff

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
A new mechanism of SAMHD1 inhibition of HIV-1 infection by induction of autophagy DOI

Chuanhua Gao,

Xing Su, Nanping Wu

et al.

Medical Hypotheses, Journal Year: 2022, Volume and Issue: 165, P. 110890 - 110890

Published: June 8, 2022

Language: Английский

Citations

0
XLID Syndrome Gene Med12 Promotes Ig Isotype Switching through Chromatin Modification and Enhancer RNA regulation DOI Creative Commons
Farazul Haque, Tasuku Honjo, Nasim A. Begum

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: June 17, 2022

ABSTRACT The transcriptional co-activator Med12 regulates gene expression through the function of its kinase module and by interacting with larger Mediator complex associated RNA Polymerase II (RNAPII). Here, we show a module-independent in antibody class switching recombination (CSR). is essential for IgH 3’ regulatory region (3’RR) or super-enhancer activation functions p300 Jmjd6/Carm1 coactivator complexes. deficiency leads to dramatic decrease H3K27 acetylation enhancer (eRNA) transcription at 3’RR, concomitant impairment AID-induced DNA double strand breaks, long-range S-S synapse formation, 3’RR-Eμ interaction. CRISPR/dCas9-mediated re-establishes epigenomic hallmarks 3’RR super-enhancer, fully restoring depletion defects. Notably, find that derived eRNAs are critical promoting proper S epigenetic regulation, formation recruitment AID locus. We specific X-Linked intellectual disability syndrome mutations defective both eRNA CSR, suggesting B neuronal cells may have cell-specific dysfunctions. conclude IgH3’RR plays central role diversification genomic instability cells.

Language: Английский

Citations

0
New Directions for Epigenetics: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research DOI
Toshitsugu Fujita, Hodaka Fujii

Elsevier eBooks, Journal Year: 2022, Volume and Issue: unknown, P. 843 - 868

Published: Sept. 16, 2022

Language: Английский

Citations

0