Journal of Experimental & Clinical Cancer Research,
Journal Year:
2022,
Volume and Issue:
41(1)
Published: Sept. 1, 2022
As
the
field
of
translational
'omics
has
progressed,
refined
classifiers
at
both
genomic
and
proteomic
levels
have
emerged
to
decipher
heterogeneity
breast
cancer
in
a
clinically-applicable
way.
The
integration
knowledge
DNA,
RNA
protein
is
further
expanding
biologic
understanding
opportunities
for
customized
treatment,
particularly
pressing
need
clinically
triple
negative
tumors.
For
this
group
aggressive
cancers,
work
from
multiple
groups
now
validated
least
four
major
biologically
distinct
omics-based
subtypes.
While
date
most
clinical
trial
designs
considered
cancers
as
single
group,
with
an
arsenal
targeted
therapies
applicable
biological
pathways,
survival
benefits
may
be
best
realized
by
designing
analyzing
trials
context
molecular
RNA-based
are
developed,
proposed
based
on
new
technologies
potential
more
directly
identify
clinically-relevant
biomarkers
therapeutic
targets.
Phospho-proteomic
data
targetable
signalling
pathways
unique
subtype-specific
manner.
Single
cell
profiling
tumor
microenvironment
represents
promising
way
allow
better
characterization
which
could
integrated
spatially
resolved
build
ecosystem-based
patient
classification.
Multi-omic
allows
silico
analysis
genetic
pharmacologic
screens
map
vulnerabilities
context.
This
review
describes
current
about
subtyping
cancer,
recent
advances
genomics
proteomics
diagnostics
addressing
diversity
disease,
key
made
through
approaches,
developments
treatments
including
therapeutics
being
tested
trials.
Science,
Journal Year:
2022,
Volume and Issue:
375(6576)
Published: Jan. 6, 2022
Ectopic
lymphoid
aggregates,
termed
tertiary
structures
(TLSs),
are
formed
in
numerous
cancer
types,
and,
with
few
exceptions,
their
presence
is
associated
superior
prognosis
and
response
to
immunotherapy.
In
spite
of
presumed
importance,
the
triggers
that
lead
TLS
formation
tissue
contribution
these
intratumoral
immune
responses
remain
incompletely
understood.
Here,
we
discuss
present
knowledge
on
TLSs
cancer,
focusing
(i)
drivers
formation,
(ii)
function
antitumor
response,
(iii)
potential
as
therapeutic
targets
human
cancers.
The EMBO Journal,
Journal Year:
2021,
Volume and Issue:
40(11)
Published: May 5, 2021
To
examine
global
changes
in
breast
heterogeneity
across
different
states,
we
determined
the
single-cell
transcriptomes
of
>
340,000
cells
encompassing
normal
breast,
preneoplastic
BRCA1
Clinical Cancer Research,
Journal Year:
2021,
Volume and Issue:
27(9), P. 2636 - 2647
Published: Feb. 23, 2021
Cancer-associated
fibroblasts
(CAFs)
are
an
important
component
of
the
tumor
microenvironment,
but
a
systematic
investigation
their
molecular
characteristics
and
clinical
relevance
lacking.
Here,
we
sought
to
compare
CAFs
across
multiple
cancer
types
identify
critical
pathways
activated
in
CAF
subtypes,
which
may
contribute
outcome,
disease
progression,
immunotherapy
resistance.We
performed
integrated
analysis
from
melanoma,
head
neck
squamous
cell
carcinoma,
lung
cancer,
identified
that
distinctly
active
each
subtype.
Gene
signatures
for
individual
subtypes
were
used
study
association
subtype
abundance
with
outcome
six
(pan-CAF)
shared
uncovered
genetic
distinguishing
them.
Interestingly,
these
express
distinct
immunosuppressive
factors,
such
as
CXCL12
CXLC14,
stem
cell-promoting
factor
IL6.
In
addition,
novel
transcriptional
drivers
(MEF2C,
TWIST1,
NR1H3,
RELB,
FOXM1)
key
heterogeneity.
Furthermore,
showed
associated
different
outcomes
could
activate
or
suppress
progression
involved
resistance
anti-PD1
anti-PD-L1
immunotherapy.Our
identifies
several
types,
implicates
benefit
targeted
therapies,
specific
resistance.
Biomarker Research,
Journal Year:
2020,
Volume and Issue:
8(1)
Published: Nov. 11, 2020
Cancer-associated
fibroblasts
(CAFs)
are
the
key
component
of
tumor
stromal.
High
heterogeneity
CAFs
reflects
in
their
origin,
phenotype
and
function.
Biological
function
which
can
be
suggested
by
biomarkers
distinct
CAF
subgroups
may
different,
even
opposite,
just
like
water
fire.
Identifying
subpopulations
expressing
different
reconciling
relationship
"water
fire"
among
subsets
a
breakthrough
therapy.
Herein,
we
briefly
summarize
commonly
used
or
newly
identified
for
terms
features
potential
clinical
benefits.
