The Hippo pathway noncanonically drives autophagy and cell survival in response to energy stress DOI Creative Commons
Gayoung Seo, Clinton Yu, Han Han

et al.

Molecular Cell, Journal Year: 2023, Volume and Issue: 83(17), P. 3155 - 3170.e8

Published: Aug. 17, 2023

Language: Английский

Autophagy and autophagy-related pathways in cancer DOI Open Access
Jayanta Debnath, Noor Gammoh, Kevin M. Ryan

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2023, Volume and Issue: 24(8), P. 560 - 575

Published: March 2, 2023

Language: Английский

Citations

715
Copper metabolism in cell death and autophagy DOI Creative Commons
Qian‐Li Xue, Rui Kang, Daniel J. Klionsky

et al.

Autophagy, Journal Year: 2023, Volume and Issue: 19(8), P. 2175 - 2195

Published: April 14, 2023

Copper is an essential trace element in biological systems, maintaining the activity of enzymes and function transcription factors. However, at high concentrations, copper ions show increased toxicity by inducing regulated cell death, such as apoptosis, paraptosis, pyroptosis, ferroptosis, cuproptosis. Furthermore, can trigger macroautophagy/autophagy, a lysosome-dependent degradation pathway that plays dual role regulating survival or death fate cells under various stress conditions. Pathologically, impaired metabolism due to environmental genetic causes implicated variety human diseases, rare Wilson disease common cancers. Therapeutically, copper-based compounds are potential chemotherapeutic agents be used alone combination with other drugs approaches treat cancer. Here, we review progress made understanding metabolic processes their impact on regulation autophagy. This knowledge may help design future clinical tools improve cancer diagnosis treatment.

Language: Английский

Citations

323
The multifaceted role of autophagy in cancer DOI Open Access
Ryan C. Russell, Kun‐Liang Guan

The EMBO Journal, Journal Year: 2022, Volume and Issue: 41(13)

Published: May 10, 2022

Language: Английский

Citations

136
Evidence of Flavonoids on Disease Prevention DOI Creative Commons
Meng Li,

Mengqi Qian,

Qian Jiang

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 527 - 527

Published: Feb. 20, 2023

A growing body of evidence highlights the properties flavonoids in natural foods for disease prevention. Due to their antioxidative, anti-inflammatory, and anti-carcinogenic activities, have been revealed benefit skeletal muscle, liver, pancreas, adipocytes, neural cells. In this review, we introduced basic classification, sources, biochemical flavonoids, then summarize experimental results underlying molecular mechanisms concerning effects flavonoid consumption on obesity, cancers, neurogenerative diseases that greatly threaten public health. Especially, dosage duration intervening these are discussed, which might guide healthy dietary habits people different physical status.

Language: Английский

Citations

69
Autophagy in aging-related diseases and cancer: Principles, regulatory mechanisms and therapeutic potential DOI
Na Wu, Wenhui Zheng,

Yundong Zhou

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102428 - 102428

Published: July 20, 2024

Language: Английский

Citations

24
Enhancing antitumor efficacy of CLDN18.2-directed antibody-drug conjugates through autophagy inhibition in gastric cancer DOI Creative Commons

Wenjing Xue,

Caili Xu,

Kaiqi Zhang

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 3, 2024

Abstract Claudin18.2 (CLDN18.2) is overexpressed in cancers of the digestive system, rendering it an ideal drug target for antibody-drug conjugates (ADCs). Despite many CLDN18.2-directed ADCs undergoing clinical trials, inconclusive underlying mechanisms pose a hurdle to extending utility these agents. In our study, αCLDN18.2-MMAE, ADC composed anti-CLDN18.2 monoclonal antibody and tubulin inhibitor MMAE, induced dose-dependent apoptosis via cleavage caspase-9/PARP proteins CLDN18.2-positive gastric cancer cells. It was worth noting that autophagy remarkably activated during αCLDN18.2-MMAE treatment, which characterized by accumulation autophagosomes, conversion marker LC3 from its form I II, complete autophagic flux. Inhibiting LY294002 enhanced αCLDN18.2-MMAE-induced cytotoxicity caspase-mediated apoptosis, indicating cytoprotective role ADC-treated Combination with significantly potentiated vivo antitumoral efficacy αCLDN18.2-MMAE. Besides, Akt/mTOR pathway inactivation demonstrated be implicated initiation αCLDN18.2-MMAE-treated conclusion, study highlighted groundbreaking investigation into mechanism ADC, focusing on crucial autophagy, providing novel insight treat combination inhibitor.

Language: Английский

Citations

24
Cancer drug-tolerant persister cells: from biological questions to clinical opportunities DOI
Mariangela Russo,

Mengnuo Chen,

Elisa Mariella

et al.

Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(10), P. 694 - 717

Published: Sept. 2, 2024

Language: Английский

Citations

20
Iron Brain Menace: The Involvement of Ferroptosis in Parkinson Disease DOI Creative Commons
Kai-Jung Lin, Shang‐Der Chen, Kai-Lieh Lin

et al.

Cells, Journal Year: 2022, Volume and Issue: 11(23), P. 3829 - 3829

Published: Nov. 29, 2022

Parkinson disease (PD) is the second-most common neurodegenerative disease. The characteristic pathology of progressive dopaminergic neuronal loss in people with PD associated iron accumulation and suggested to be driven part by novel cell death pathway, ferroptosis. A unique modality death, ferroptosis mediated iron-dependent phospholipid peroxidation. mechanisms inhibitors enhance antioxidative capacity counter oxidative stress from lipid peroxidation, such as through system xc−/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis coenzyme Q10 (CoQ10)/FSP1 pathway. Another means reduce chelators. To date, there no disease-modifying therapy cure or slow progression, a recent topic research seeks intervene development via regulation In this review, we provide discussion different pathways, molecular ferroptosis, role blood–brain barrier damage, updates on studies latest progress pharmacological agents targeting for intervention clinical trials.

Language: Английский

Citations

41
Redox signaling in drug-tolerant persister cells as an emerging therapeutic target DOI Creative Commons
Zhe Zhang,

Yunhan Tan,

Canhua Huang

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 89, P. 104483 - 104483

Published: Feb. 22, 2023

Language: Английский

Citations

38
The Role of Retinal Pigment Epithelial Cells in Age-Related Macular Degeneration: Phagocytosis and Autophagy DOI Creative Commons

Zhibo Si,

Yajuan Zheng, Jing Zhao

et al.

Biomolecules, Journal Year: 2023, Volume and Issue: 13(6), P. 901 - 901

Published: May 29, 2023

Age-related macular degeneration (AMD) causes vision loss in the elderly population. Dry AMD leads to formation of Drusen, while wet is characterized by cell proliferation and choroidal angiogenesis. The retinal pigment epithelium (RPE) plays a key role pathogenesis. In particular, helioreceptor renewal depends on outer segment phagocytosis RPE cells, autophagy can protect cells from oxidative stress damage. However, when burden too high homeostasis disturbed, functions become damaged, leading development progression. Hence, characterizing roles pathogenesis inform potential therapeutic targets prevent irreversible photoreceptor death, thus protecting against AMD.

Language: Английский

Citations

24