Cancers,
Journal Year:
2023,
Volume and Issue:
15(17), P. 4338 - 4338
Published: Aug. 30, 2023
YY1
is
widely
recognized
as
an
intrinsically
disordered
transcription
factor
that
plays
a
role
in
development
of
many
cancers.
In
most
cases,
its
overexpression
correlated
with
tumor
progression
and
unfavorable
patient
outcomes.
Our
latest
research
focusing
on
the
zinc
ions
modulating
YY1’s
interaction
DNA
demonstrated
enhances
protein’s
multimeric
state
affinity
to
operator.
light
these
findings,
changes
protein
concentration
appear
be
just
one
element
relevant
YY1-dependent
processes.
Thus,
alterations
ion
can
directly
specifically
impact
regulation
gene
expression
by
YY1,
line
reports
indicating
correlation
between
levels
advancement
certain
tumors.
This
review
concentrates
other
potential
consequences
may
act
altering
charge
distribution,
conformational
or
oligomerization
influence
interactions
molecular
partners
disrupt
patterns.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8550 - 8595
Published: June 17, 2024
Biomolecular
condensates,
formed
through
phase
separation,
are
upending
our
understanding
in
much
of
molecular,
cell,
and
developmental
biology.
There
is
an
urgent
need
to
elucidate
the
physicochemical
foundations
behaviors
properties
biomolecular
condensates.
Here
we
aim
fill
this
by
writing
a
comprehensive,
critical,
accessible
review
on
fundamental
aspects
phase-separated
We
introduce
relevant
theoretical
background,
present
basis
for
computation
experimental
measurement
condensate
properties,
give
mechanistic
interpretations
terms
interactions
at
molecular
residue
levels.
European Journal of Neuroscience,
Journal Year:
2024,
Volume and Issue:
60(1), P. 3505 - 3543
Published: May 15, 2024
Abstract
Copper
is
a
critical
trace
element
in
biological
systems
due
the
vast
number
of
essential
enzymes
that
require
metal
as
cofactor,
including
cytochrome
c
oxidase,
superoxide
dismutase
and
dopamine‐
β
‐hydroxylase.
Due
its
key
role
oxidative
metabolism,
antioxidant
defence
neurotransmitter
synthesis,
copper
particularly
important
for
neuronal
development
proper
function.
Moreover,
increasing
evidence
suggests
also
serves
functions
synaptic
network
activity,
regulation
circadian
rhythms,
arousal.
However,
it
to
note
because
copper's
ability
redox
cycle
generate
reactive
species,
cellular
levels
must
be
tightly
regulated
meet
needs
while
avoiding
copper‐induced
stress.
Therefore,
intricate
system
transporters,
exporters,
chaperones
trafficking
proteins
function
properly
coordinate
fashion.
Indeed,
disorders
metabolism
such
Menkes
disease
Wilson
disease,
well
diseases
linked
dysfunction
copper‐requiring
enzymes,
SOD1‐linked
amyotrophic
lateral
sclerosis,
demonstrate
dramatic
neurological
consequences
altered
homeostasis.
In
this
review,
we
explore
physiological
importance
nervous
pathologies
related
improper
handling.
Current Opinion in Chemical Biology,
Journal Year:
2023,
Volume and Issue:
75, P. 102317 - 102317
Published: May 17, 2023
The
phenomenon
of
protein
phase
separation,
which
underlies
the
formation
biomolecular
condensates,
has
been
associated
with
numerous
cellular
functions.
Recent
studies
indicate
that
amino
acid
sequences
most
proteins
may
harbour
not
only
code
for
folding
into
native
state
but
also
condensing
liquid-like
droplet
and
solid-like
amyloid
state.
Here
we
review
current
understanding
principles
sequence-based
methods
predicting
propensity
separation.
A
guiding
concept
is
entropic
contributions
are
generally
more
important
to
stabilise
than
they
states.
Although
estimating
these
proven
difficult,
describe
some
progress
recently
made
in
this
direction.
To
conclude,
discuss
challenges
ahead
extend
prediction
separation
include
quantitative
vivo
characterisations
process.
