Current Biology, Journal Year: 2023, Volume and Issue: 33(23), P. R1229 - R1231
Published: Dec. 1, 2023
Language: Английский
The EMBO Journal, Journal Year: 2024, Volume and Issue: 43(13), P. 2813 - 2833
Published: May 22, 2024
Language: Английский
Citations
8
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117803 - 117803
Published: Jan. 2, 2025
Language: Английский
Citations
1
PLoS Pathogens, Journal Year: 2024, Volume and Issue: 20(5), P. e1012157 - e1012157
Published: May 9, 2024
Circadian rhythms are intrinsic 24-hour oscillations found in nearly all life forms. They orchestrate key physiological and behavioral processes, allowing anticipation response to daily environmental changes. These manifest across entire organisms, various organs, through intricate molecular feedback loops that govern cellular oscillations. Recent studies describe circadian regulation of pathogens, including parasites, bacteria, viruses, fungi, some which have their own while others influenced by the rhythmic environment hosts. Pathogens target specific tissues organs within host optimize replication. Diverse compositions interplay among cell types create unique microenvironments different tissues, distinctive biology. Hence, residing pathogens exposed cyclic conditions, can profoundly impact host–pathogen interactions. This review explores influence mammalian tissue-specific interactions on dynamics pathogen–host relationships. Overall, this demonstrates between body’s internal timekeeping system its susceptibility has implications for future infectious disease research treatment.
Language: Английский
Citations
7
Free Radical Biology and Medicine, Journal Year: 2024, Volume and Issue: 223, P. 1 - 17
Published: July 20, 2024
Plastic material versatility has resulted in a substantial increase its use several sectors of our everyday lives. Consequently, concern regarding human exposure to nano-plastics (NPs) and micro-plastics (MPs) recently increased. It been shown that plastic particles entering the bloodstream may adhere erythrocyte surface exert adverse effects following aggregation adhesion blood vessels. Here, we explored polystyrene (PS-NPs) (PS-MPs) on erythrocytes. Cellular morphology, binding/internalization PS-NPs PS-MPs, oxidative stress parameters, as well distribution anion exchange capability band 3 (anion exchanger 1; SLC4A1) have analyzed erythrocytes exposed 1 μg/mL or PS-MPs for 24 h, respectively. The data obtained showed significant modifications cellular shape after PS-MPs. In particular, significantly increased number acanthocytes, echinocytes leptocytes were detected. However, percentage eryptotic cells (<1 %) was comparable physiological conditions. Analytical cytology confocal microscopy bound plasma membrane, co-localized with estrogen receptors (Erα/ERβ), internalized. An trafficking from cytosol membrane abnormal ERs also observed, consistent ERα-mediated binding internalization PS-NPs. phosphorylation ERK1/2 AKT kinases indicated an activation ER-modulated non-genomic pathway occurred Interestingly, caused production reactive oxygen species, resulting lipid peroxidation protein sulfhydryl group oxidation. Oxidative associated altered ion transport activity oxidized haemoglobin, which led clustering membrane. Taken together, these findings identify events contribute elucidating potential stress-related harmful effects, affect systemic homeostasis.
Language: Английский
Citations
7
Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)
Published: Sept. 23, 2024
Abstract The circadian clock is an evolutionarily conserved time-keeper that regulates physiological processes across 24 h. In the cardiovascular system, several parameters, such as blood pressure, heart rate, and metabolism, exhibit time-of-day variations. These features are in part driven by clock. Chronic perturbation of diurnal rhythmicity due to shift work or irregular social schedules has been associated with increased risk hypertension, arrhythmias, myocardial infarction. This review discusses impact rhythms on human health effect disruption occurrence adverse cardiac events. Additionally, we discuss how main factors diseases, obesity, sleep disorders, aging, affect rhythms. Finally, elaborate chronotherapy well targeting highlight novel approaches translate our scientific understanding into clinical practice.
Language: Английский
Citations
5
The EMBO Journal, Journal Year: 2023, Volume and Issue: 42(19)
Published: Aug. 9, 2023
Cellular circadian rhythms confer temporal organisation upon physiology that is fundamental to human health. Rhythms are present in red blood cells (RBCs), the most abundant cell type body, but their physiological function poorly understood. Here, we a novel biochemical assay for haemoglobin (Hb) oxidation status which relies on redox-sensitive covalent haem-Hb linkage forms during SDS-mediated lysis. Formation of this lowest when ferrous Hb oxidised, form ferric metHb. Daily observed mouse and RBCs cultured vitro, or taken from humans vivo, unaffected by mutations affect nucleated cells. These correlate with daily core body temperature, temperature metHb levels highest. Raising dietary sodium nitrite can further decrease daytime mice via nitric oxide (NO) signalling. results extend our molecular understanding RBC suggest they contribute regulation temperature.
Language: Английский
Citations
13
Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Abstract Objectives Chronobiology is the science that studies biological rhythms based on direct methods and empirical time series of individual subjects. In laboratory medicine, factor often underestimated, no currently exist to study in population databases point-like, real-world data (RWD). Methods Retrospective (24 months, 2022–2023) were extracted for four measurands (sodium, potassium, chloride leukocytes) from emergency laboratory. Two different strategies grouping applied: clouds (with or without outliers) population-averaged profiles. Cosinor regression analysis was performed grouped derive circadian parameters. The parameters obtained here compared results literature, using series. Results A total 409,719 points analyzed. All exhibited symmetrical distributions, except leukocytes. did not visually display rhythmicity, but cosinor revealed a significant rhythm. removal outliers had minimal impact results. contrast, profiles showed visible which confirmed by with better goodness-of-fit clouds. Conclusions Population-averaged have advantages over characterizing deriving Population chronobiology, RWD, presented as an alternative classical overcomes limitations methods. Utilizing RWD provides new insights into relationship between chronobiology clinical practice.
Language: Английский
Citations
0
Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)
Published: March 26, 2025
Abstract The circadian clock is a transcriptional-translational feedback loop which oscillates in virtually all nucleated cells of the body. In decades since its discovery, it has become evident that molecular clockwork inextricably linked to energy metabolism. Given frequency with metabolic dysfunction and disruption co-occur, understanding why how processes are reciprocally coupled will have important implications for supporting human health wellbeing. Here, we discuss relevance function tissues explore role not only as driver day-night variation gene expression, but key mechanism maintaining homeostasis face fluctuating supply demand.
Language: Английский
Citations
0
Journal of Biological Rhythms, Journal Year: 2025, Volume and Issue: unknown
Published: March 27, 2025
While there is extensive literature on both the neuronal circuitry of rhythms and intracellular molecular clock, a large component signaling that has been understudied: interstitial fluid (ISF)—fluid surrounds cells in extracellular space tissue. In this review, we highlight evidence circadian supporting ISF as key to synchronization entrainment propose new mechanisms how movement between brain periphery may act zeitgebers by examining main pathways body, focusing regulation glymphatic lymphatic systems. We identify pieces research point an important timing medium, expand basics cerebrospinal (CSF) production, outline basic structure function
Language: Английский
Citations
0
Journal of Circadian Rhythms, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 1, 2024
Chronobiology investigations have revealed much about cellular and physiological clockworks but we are far from having a complete mechanistic understanding of the ecological implications. Here present some unresolved questions in circadian biology research as posed by editorial staff guest contributors to Journal Circadian Rhythms. This collection ideas is not meant be comprehensive does reveal breadth our observations on emerging trends chronobiology biology. It amazing what could achieved with various expected innovations technologies, techniques, mathematical tools that being developed. We fully expect strengthening work will linked health care environmental understandings function. Now most clock genes known, linking these physiological, metabolic, developmental traits requires single molecule terrestrial scales. Real answers for over next decade. Where clocks at level? How coupled cellularly generate organism level outcomes? do communities organisms rhythmically interact each other? In way natural genetic variation populations sculpt community behaviors? methods development used disparate academic commercial endeavors? These other make it very exciting time working chronobiologist.
Language: Английский
Citations
3