Cells,
Journal Year:
2024,
Volume and Issue:
13(9), P. 724 - 724
Published: April 23, 2024
Bone
marrow
(BM)
acts
as
a
dynamic
organ
within
the
bone
cavity,
responsible
for
hematopoiesis,
skeletal
remodeling,
and
immune
system
control.
adipose
tissue
(BMAT)
was
long
simply
considered
filler
of
space,
but
now
it
is
known
that
instead
constitutes
an
essential
element
BM
microenvironment
participates
in
homeostasis,
influences
health
alters
hematopoietic
stem
cell
functions,
contributes
to
commitment
mesenchymal
cells,
provides
effects
homeostasis
defense
against
infections,
energy
metabolism
inflammation.
BMAT
has
emerged
significant
contributor
development
progression
various
diseases,
shedding
light
on
its
complex
relationship
with
health.
Notably,
been
implicated
metabolic
disorders,
hematological
malignancies,
conditions.
shown
support
proliferation
tumor
cells
acute
myeloid
leukemia
niche
adipocytes
have
found
protect
cancer
chemotherapy,
contributing
treatment
resistance.
Moreover,
BMAT’s
impact
density
remodeling
can
lead
conditions
like
osteoporosis,
where
high
levels
are
inversely
correlated
mineral
density,
increasing
risk
fractures.
also
associated
diabetes,
obesity,
anorexia
nervosa,
varying
individuals
depending
their
weight
status.
Understanding
interaction
between
different
diseases
may
new
therapeutic
strategies.
Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
32(51)
Published: Oct. 9, 2022
Abstract
With
an
increasingly
aging
society,
bone
defects
and
fractures
have
become
significant
threats
to
human
health
quality
of
life.
Currently,
autologous
allogeneic
grafts
remain
the
“gold
standard”
for
clinical
treatment
repair.
However,
transplantation
is
still
clinically
insufficient,
owing
its
substantial
limitations,
such
as
graft
rejection,
donor
functional
defects,
risk
infection.
Therefore,
a
variety
biomaterials
been
developed
facilitate
advancement
tissue
engineering,
focus
research
has
transitioned
from
bioinert
bioactive
biomaterials.
many
not
achieved
satisfactory
therapeutic
effects.
In
recent
years,
advancements
in
osteoimmunology
revealed
that
immune
system,
which
macrophages
are
critical
components,
plays
essential
regulatory
role
regeneration.
this
review,
healing
explored
developments
promote
regeneration
by
modulating
macrophage
polarization
improving
osteoimmune
microenvironment
reviewed.
This
review
provides
reference
development
application
repair
immunomodulation
perspective.
Cell Reports Medicine,
Journal Year:
2023,
Volume and Issue:
4(1), P. 100881 - 100881
Published: Jan. 1, 2023
Systematic
bone
loss
is
commonly
complicated
with
inflammatory
bowel
diseases
(IBDs)
unclear
pathogenesis
and
uncertain
treatment.
In
experimental
colitis
mouse
models
established
by
dextran
sulfate
sodium
IL-10
knockout
induced
piroxicam,
mass
quality
are
significantly
decreased.
Colitis
mice
demonstrate
a
lower
formation
rate
fewer
osteoblasts
in
femur.
Bone
marrow
mesenchymal
stem/stromal
cells
(BMSCs)
from
tend
to
differentiate
into
adipocytes
rather
than
osteoblasts.
Serum
patients
IBD
promotes
adipogenesis
of
human
BMSCs.
RNA
sequencing
reveals
that
downregulates
Wnt
signaling
For
treatment,
exosomes
Golgi
glycoprotein
1
inserted
could
carry
agonist
accumulate
via
intravenous
administration.
They
alleviate
loss,
promote
formation,
accelerate
fracture
healing
mice.
Collectively,
BMSC
commitment
microenvironment
contributes
quantity
be
rescued
redirecting
differentiation
toward
through
bone-targeted
drug
delivery.
Theranostics,
Journal Year:
2022,
Volume and Issue:
12(11), P. 5103 - 5124
Published: Jan. 1, 2022
Osteoarthritis
(OA)
is
a
common
joint
disease
with
high
disability
rate.In
addition,
OA
not
only
causes
great
physiological
and
psychological
harm
to
patients,
but
also
puts
pressure
on
the
social
healthcare
system.Pathologically,
disintegration
of
cartilage
lesions
subchondral
bone
are
related
OA.Currently,
tissue
engineering,
which
expected
overcome
defects
existing
treatment
methods,
had
lot
research
in
field
cartilage/osteochondral
repair.Silk
fibroin
(SF),
as
natural
macromolecular
material
good
biocompatibility,
unique
mechanical
properties,
excellent
processability
degradability,
holds
potential
engineering.Nowadays,
SF
been
prepared
into
various
materials
adapt
demands
repair.SF-based
biomaterials
can
be
functionally
modified
enhance
repair
performance
further.In
this
review,
preparation
types,
structures,
functional
modifications
SF-based
used
for
summarized
discussed.We
hope
that
review
will
provide
reference
design
development
field.
Abstract
Osteoporotic
fractures
lead
to
increased
disability
and
mortality
in
the
elderly
population.
With
rapid
increase
aging
population
around
globe,
more
effective
treatments
for
osteoporosis
osteoporotic
are
urgently
required.
The
underlying
molecular
mechanisms
of
believed
be
due
activity
osteoclasts,
decreased
osteoblasts,
or
both,
which
leads
an
imbalance
bone
remodeling
process
with
accelerated
resorption
attenuated
formation.
Currently,
available
clinical
have
mostly
focused
on
factors
influencing
remodeling;
however,
they
their
own
limitations
side
effects.
Recently,
cytokine
immunotherapy,
gene
therapy,
stem
cell
therapy
become
new
approaches
treatment
various
diseases.
This
article
reviews
latest
research
mechanisms,
as
well
how
this
underpins
current
potential
novel
osteoporosis.
Science Advances,
Journal Year:
2023,
Volume and Issue:
9(14)
Published: April 5, 2023
Abnormal
subchondral
bone
remodeling
featured
by
overactivated
osteoclastogenesis
leads
to
articular
cartilage
degeneration
and
osteoarthritis
(OA)
progression,
but
the
mechanism
is
unclear.
We
used
lymphocyte
cytosolic
protein
1
(Lcp1)
knockout
mice
suppress
osteoclasts
in
a
OA
model
with
anterior
cruciate
ligament
transection
(ACLT),
Lcp1-/-
showed
decreased
retarded
degeneration.
For
mechanisms,
activated
induced
type-H
vessels
elevated
oxygen
concentration,
which
ubiquitylated
hypoxia-inducible
factor
alpha
subunit
(HIF-1α)
chondrocytes
led
Lcp1
impeded
angiogenesis,
maintained
hypoxia
environment
joints
delayed
progression.
Stabilization
of
HIF-1α
degeneration,
knockdown
Hif1a
abolished
protective
effects
knockout.
Last,
we
that
Oroxylin
A,
an
Lcp1-encoded
l-plastin
(LPL)
inhibitor,
could
alleviate
In
conclusion,
maintaining
hypoxic
attractive
strategy
for
treatment.
Annual Review of Pathology Mechanisms of Disease,
Journal Year:
2022,
Volume and Issue:
18(1), P. 257 - 281
Published: Oct. 7, 2022
Osteoclasts
are
multinucleated
cells
with
the
unique
ability
to
resorb
bone
matrix.
Excessive
production
or
activation
of
osteoclasts
leads
skeletal
pathologies
that
affect
a
significant
portion
population.
Although
therapies
effectively
target
have
been
developed,
they
associated
sometimes
severe
side
effects,
and
fuller
understanding
osteoclast
biology
may
lead
more
specific
treatments.
Along
those
lines,
rich
body
work
has
defined
essential
signaling
pathways
required
for
formation,
function,
survival.
Nonetheless,
recent
studies
cast
new
light
on
long-held
views
regarding
origin
these
during
development
homeostasis,
their
life
span,
cellular
sources
factors
drive
activity
homeostasis
disease.
In
this
review,
we
discuss
findings
in
context
existing
highlight
areas
ongoing
future
investigation.
Frontiers in Cell and Developmental Biology,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 3, 2022
Bone
marrow
mesenchymal
stromal
cells
(BMSCs),
identified
as
pericytes
comprising
the
hematopoietic
niche,
are
a
group
of
heterogeneous
composed
multipotent
stem
cells,
including
osteochondral
and
adipocyte
progenitors.
Nevertheless,
identification
classification
still
controversial,
which
limits
their
application.
In
recent
years,
by
lineage
tracing
single-cell
sequencing,
several
new
subgroups
BMSCs
roles
in
normal
physiological
pathological
conditions
have
been
clarified.
Key
regulators
mechanisms
controlling
fate
being
revealed.
Cross-talk
among
bone
has
demonstrated.
this
review,
we
focus
on
advances
BMSCs,
provides
important
implications
for
clinical
applications.
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Jan. 4, 2024
Osteoporosis
is
a
systemic
skeletal
disease
that
seriously
endangers
the
health
of
middle-aged
and
older
adults.
Recently,
with
continuous
deepening
research,
an
increasing
number
studies
have
revealed
gut
microbiota
as
potential
target
for
osteoporosis,
research
concept
gut-bone
axis
has
gradually
emerged.
Additionally,
intake
dietary
nutrients
adoption
patterns
may
affect
microbiota,
alterations
in
might
also
influence
metabolic
status
host,
thus
adjusting
bone
metabolism.
Based
on
axis,
can
participate
modulation
metabolism
by
altering
abundance,
diversity,
composition
microbiota.
Herein,
combined
emerging
literatures
relevant
studies,
this
review
aimed
to
summarize
impacts
different
components
osteoporosis
acting
well
underlying
mechanisms
proper
recommendations.
