Non-canonical functions of regulated cell death machinery regulate cellular growth, invasion and the interplay between cell death modalities

Frontiers in Cell Death, Journal Year: 2024, Volume and Issue: 3

Published: July 15, 2024

The exploration of multiple regulated cell death (RCD) pathways and the recognition that several death-related proteins, including caspases, serve non-canonical roles have significantly expanded diversified research. Caspases not only cleave cellular substrates, triggering apoptosis, but also impact essential processes such as differentiation, proliferation, growth, migration. These novel caspase-dependent regulatory networks are extensively studied during development, with Drosophila providing a diverse range developmental models for investigating these phenomena. Moreover, recent insights into functions proteins highlighted their pivotal role in cancer aggressiveness. Ultimately, understanding sheds light on intricate connections between RCD significance promoting anti-oncogenic responses.

Language: Английский

Something new under the sun: caspases promote cell survival under moderate heat stress

EMBO Reports, Journal Year: 2023, Volume and Issue: 24(6)

Published: May 11, 2023

Language: Английский