Maternal dietary habit influences fetal life DOI Creative Commons
Ruby Dhar, Arun Kumar, Subhradip Karmakar

et al.

Asian Journal of Medical Sciences, Journal Year: 2023, Volume and Issue: 14(11), P. 1 - 2

Published: Nov. 1, 2023

Diet and nutrition have a tremendous influence on health disease. Dietary constituents can affect been known to supplement with essential nutrients, minerals, calories for physiological homeostasis. However, diet also gene expression through epigenetic reprogramming or by altering the level of micronutrients. While nutrigenomics study has delineated this causal link, recent published in EMBO Molecular Medicine Grant et al. went step further establish that maternal intake dietary fibers alter fetal gut microbiome, influencing diversity intestinal bacterial flora, thereby affecting gut-brain axis. Although relationship between fertility males females reported, effect postnatal life is not well documented. In at (Luxembourg Institute Health, Esch-sur-Alzette, Luxembourg), authors reported selected feeding fiber-free diets pregnant mice alters microbiome composition their neonate pups depriving them protective beneficial commensal, Akkermansia muciniphila, mucin-foraging bacterium. Further, these animals exhibited heightened immune activity enriching defense response pathways IL-22 expression. Therefore, role A. muciniphila associated its protection against chronic inflammation TLR4 signaling. The author’s far-reaching conclusions improving human outcomes rational choice food, drugs, lifestyle prevent dysbiosis colonization right microbiome.

Language: Английский

A maternal sweet diet is associated with the gut dysbiosis in the first trimester of pregnancy DOI Creative Commons

Navid Momeni,

Seyedeh Neda Mousavi,

Hossein Chiti

et al.

BMC Nutrition, Journal Year: 2024, Volume and Issue: 10(1)

Published: Dec. 18, 2024

Language: Английский

Citations

0
Gut Microbiota‐Derived Hyocholic Acid Enhances Type 3 Immunity and Protects Against Salmonella enterica Serovar Typhimurium in Neonatal Rats DOI Creative Commons
Zhipeng Yang, Zhiyuan Lin,

Yaojie You

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 31, 2024

Abstract This study investigates how microbiome colonization influences the development of intestinal type 3 immunity in neonates. The results showed that reduced oxygen levels small intestine neonatal rats induced by Saccharomyces boulardii accelerated and development, which protected against Salmonella enterica serovar Typhimurium infection. Microbiome maturation increased abundance microbiome‐encoded bile salt hydrolase ( BSH ) genes hyocholic acid (HCA) levels. Furthermore, reducing Limosilactobacillus reuteri , a bacterium encoding promoted immunity. However, inhibition blocked L. reuteri‐ Mechanistically, HCA gamma‐delta T cells innate lymphoid stabilizing mRNA expression RAR‐related orphan receptor C via farnesoid X receptor–WT1‐associated protein‐N6‐methyl‐adenosine axis. These reveal gut microbiota‐derived plays crucial role promoting discovery introduces potential therapeutic avenues for strengthening early life or treating bacterial infections targeting microbial metabolites.

Language: Английский

Citations

0
Diet-driven differential response ofAkkermansia muciniphilamodulates pathogen susceptibility DOI Creative Commons
Mathis Wolter, Erica T. Grant, Marie Boudaud

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 15, 2023

The erosion of the colonic mucus layer by a dietary fiber-deprived gut microbiota results in heightened susceptibility to an attaching and effacing pathogen,

Language: Английский

Citations

1
Early-life Microbiome-Derived HCA Enhances Type 3 Immunity via FXR-dependent m6A RNA methylation DOI
Zhipeng Yang, Zhiyuan Lin,

Yaojie You

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 6, 2024

Abstract The gut microbiome plays a crucial role in the development of intestinal immunity during early life, but underlying mechanisms remain largely unknown. Here, we found oxygen consumption neonatal rats by S. boulardii accelerated colonization and type 3 immunity, which protected against typhimurium . Microbiome maturation increased abundance microbiome-encoded bile salt hydrolase (BSH) genes elevated levels Hyocholic acid (HCA). HCA promotes γδT innate lymphoid cell (ILC3) sustaining stability Rorc mRNA via FXR-WTAP- N6-methyl-adenosine (m 6 A) axis. L. reuteri , bacterium encoding BSH, was enriched intestine promoted immunity. However, inhibition BSH blocks reuteri- induced These results reveal microbiome-derived regulation life.

Language: Английский

Citations

0
Maternal dietary habit influences fetal life DOI Creative Commons
Ruby Dhar, Arun Kumar, Subhradip Karmakar

et al.

Asian Journal of Medical Sciences, Journal Year: 2023, Volume and Issue: 14(11), P. 1 - 2

Published: Nov. 1, 2023

Diet and nutrition have a tremendous influence on health disease. Dietary constituents can affect been known to supplement with essential nutrients, minerals, calories for physiological homeostasis. However, diet also gene expression through epigenetic reprogramming or by altering the level of micronutrients. While nutrigenomics study has delineated this causal link, recent published in EMBO Molecular Medicine Grant et al. went step further establish that maternal intake dietary fibers alter fetal gut microbiome, influencing diversity intestinal bacterial flora, thereby affecting gut-brain axis. Although relationship between fertility males females reported, effect postnatal life is not well documented. In at (Luxembourg Institute Health, Esch-sur-Alzette, Luxembourg), authors reported selected feeding fiber-free diets pregnant mice alters microbiome composition their neonate pups depriving them protective beneficial commensal, Akkermansia muciniphila, mucin-foraging bacterium. Further, these animals exhibited heightened immune activity enriching defense response pathways IL-22 expression. Therefore, role A. muciniphila associated its protection against chronic inflammation TLR4 signaling. The author’s far-reaching conclusions improving human outcomes rational choice food, drugs, lifestyle prevent dysbiosis colonization right microbiome.

Language: Английский

Citations

0