Genetic influences for distinct impulsivity domains are differentially associated with early substance use initiation: Results from the ABCD Study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Impulsivity is among the strongest correlates of substance involvement and its distinct domains (e.g., sensation seeking, urgency) are differentially correlated, phenotypically genetically, with unique stages. Understanding whether polygenic influences for impulsivity predictive early use initiation, a major risk factor later problematic use, will improve our understanding role in addiction etiology. Data collected from participants ( n =4,808) genetically-inferred European ancestry enrolled Adolescent Brain Cognitive Development Study SM were used to estimate associations between scores (PGS) UPPS-P (i.e., lack premeditation/perseverance, negative/positive any, alcohol, nicotine, cannabis) initiation before age 15. Mediation models examined child (ages 9-11) mediated links PGSs initiation. Sensation seeking PGS was significantly associated any alcohol (ORs>1.10, p s FDR <0.006). Lack perseverance urgency (negative/positive) nominally nicotine respectively (ORs>1.06, s<0.05, ps >0.05). No significant observed premeditation or cannabis Measured accounted 5-9% Genetic have differential showing most robust associations. Evaluating genetic can yield valuable etiologic insight into earliest stages that may be missed when adopting broad definitions.

Language: Английский

Binge drinking trajectories across adolescence and early adulthood: Associations with genetic influences for dual-systems impulsive personality traits, alcohol consumption, and alcohol use disorder

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 16, 2024

Abstract Binge drinking is a relatively common pattern of alcohol use among youth with normative frequency trajectories peaking in emerging and early adulthood. Frequent binge critical risk factor for not only the development disorders (AUDs) but also increased odds alcohol-related injury death, thus constitutes significant public health concern. Changes across are strongly associated changes impulsive personality traits (IPTs) which have been hypothesized as intermediate phenotypes genetic heavy AUD. The current study sought to examine extent longitudinal intoxication adolescence adulthood influences underlying dual-systems IPTs (i.e., top-down [lack self-control] bottom-up [sensation seeking urgency] constructs) alongside consumption Associations were tested using conditional latent growth curve polygenic score (PGS) models three independent samples ( N =10,554). Results suggested consistent associations all between sensation PGSs model intercepts higher at first measurement occasion) slopes steeper increases toward peak frequency). Urgency significantly or frequency. Collectively, these findings highlight role unique correlated IPT alcohol-specific factors emergence escalation during

Language: Английский