Endocrine disrupting chemicals: exposure, effects on human health, mechanism of action, models for testing and strategies for prevention

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2019, Volume and Issue: 21(1), P. 127 - 147

Published: Dec. 3, 2019

Language: Английский

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Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases

Frontiers in Public Health, Journal Year: 2020, Volume and Issue: 8

Published: Sept. 24, 2020

The exponential growth of pollutant discharges into the environment due to increasing industrial and agricultural activities is a rising threat for human health biggest concern environmental globally. Several synthetic chemicals, categorized as potential endocrine-disrupting chemicals (EDCs), are evident affect not only livestock wildlife but also humankind. In recent years, exposure EDCs has received increased awareness their association with altered documented by several epidemiological experimental studies. associated deleterious effects on male female reproductive health; causes diabetes, obesity, metabolic disorders, thyroid homeostasis increase risk hormone-sensitive cancers. Sewage effluents major source EDCs, which eventually reach large water bodies potentially contaminate drinking supply. Similarly, storage material such different types plastics leaches out in Water. Domestic wastewater containing pharmaceutical ingredients, metals, pesticides personal care product additives influences endocrine activity. These act via various receptors through variety known unknown mechanisms including epigenetic modification. They differ from classic toxins ways low-dose effect, non-monotonic dose trans-generational effects. This review aims highlight hidden burden discusses non-classical toxic properties an attempt understand magnitude exposome health. Present data advocate that there may be associations between undesirable outcomes warrants further bio-monitoring EDCs.

Language: Английский

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A comprehensive review on chlorpyrifos toxicity with special reference to endocrine disruption: Evidence of mechanisms, exposures and mitigation strategies

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 755, P. 142649 - 142649

Published: Oct. 1, 2020

Language: Английский

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Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Frontiers in Endocrinology, Journal Year: 2019, Volume and Issue: 10

Published: Dec. 9, 2019

Plant Protection Products, more commonly referred to as pesticides and biocides, are used control a wide range of yield-reducing pests including insects, fungi, nematodes, weeds. Concern has been raised that some may act endocrine disrupting chemicals (EDCs) with the potential interfere hormone systems non-target invertebrates vertebrates, humans. EDCs at low doses particularly vulnerable periods exposure include pre- perinatal development. Of critical concern is number developing nervous system brain, notably thyroid signaling. Across orchestrates metamorphosis, brain development, metabolism. Pesticide action on homeostasis can involve interference TH production its control, displacement from distributor proteins liver Here we focused endpoints for each different classes reviewing epidemiological experimental studies carried out both in vivo vitro. We conclude first, many were placed market insufficient testing, other than acute or chronic toxicity, second, thyroid-specific neurodevelopmental effects mixture assessment largely absent regulatory directives.

Language: Английский

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Impact of environmental pollution from human activities on water, air quality and climate change

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: June 1, 2024

Interactions between humans and the physical environment in which they live have been studied extensively reason being that human activities to a great extent exert an influence on (biotic abiotic). Pollution other hand is introducing harmful substances into are damaging living organisms. Pollutants can be gases, liquids or solids produced concentrations higher than usual diminish quality of environment. Human adverse effects by polluting air we breathe, water drink even cause climatic changes. In terms provision manifold services, technology societal modernization, industrial revolution recorded outstanding success, it however, was beginning mass production pollutants emitted caused health our era, industrialization urbanization evidently reaching unprecedented disturbing proportions globally with anthropogenic pollution one major public hazards, accounting for almost 9 million deaths annually. This research therefore aims investigate environmental from activities, particularly water, climate change provide comprehensive understanding interconnectedness their consequences. Furthermore, since emerges as global concern developing countries; this study thus also highlights significance efficient wastewater treatment crucial strategy sustainable development, exploring its potential contribution mitigation.

Language: Английский

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Water Quality, Air Pollution, and Climate Change: Investigating the Environmental Impacts of Industrialization and Urbanization

Water Air & Soil Pollution, Journal Year: 2025, Volume and Issue: 236(2)

Published: Jan. 3, 2025

Language: Английский

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The Role of Iodine for Thyroid Function in Lactating Women and Infants

Endocrine Reviews, Journal Year: 2021, Volume and Issue: 43(3), P. 469 - 506

Published: Nov. 17, 2021

Iodine is a micronutrient needed for the production of thyroid hormones, which regulate metabolism, growth, and development. deficiency or excess may alter hormone synthesis. The potential effects on infant development depend degree, timing, duration exposure. iodine requirement particularly high during infancy because elevated turnover. Breastfed infants rely provided by human milk, but concentration in breast milk determined maternal intake. Diets many countries cannot provide sufficient iodine, prevented fortification salt. However, coverage iodized salt varies between countries. Epidemiological data suggest large differences intake lactating women, infants, toddlers worldwide, ranging from deficient to excessive In this review, we an overview current knowledge recent advances understanding nutrition its association with function toddlers. We discuss risk factors malnutrition impact targeted intervention strategies these vulnerable population groups. highlight importance appropriate definitions optimal need more assessing mild disorders first 2 years life.

Language: Английский

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Association of phthalate exposure with thyroid function during pregnancy

Environment International, Journal Year: 2021, Volume and Issue: 157, P. 106795 - 106795

Published: Aug. 4, 2021

The extent of thyroid disruptive effects phthalates during pregnancy remains unclear.To investigate the association maternal urinary with markers system early pregnancy.Urinary concentrations phthalate metabolites and serum stimulating hormone (TSH), free total thyroxine (FT4 TT4) triiodothyronine (FT3 TT3) were measured in pregnant women Swedish Environmental Longitudinal, Mother child, Asthma allergy study (2007-ongoing), a population-based prospective cohort.In 1,996 included women, higher di-ethyl-hexyl (DEHP) associated lower FT4 (β [SE] for molar sum: -0.13 [0.06], P = 0.03) TSH/FT4 ratio (0.003 [0.001], 0.03). Higher di-iso-nonyl (DINP) TT4 0.93 [0.44], as well TT4/FT4 TT4/TT3 ratios. both dibutyl butyl-benzyl (DBP BBzP) T4/T3 (free total) FT4/TT4 FT3/TT3 A diisononyl cyclohexane dicarboxylate (DINCH) metabolite concentration was TT3.These results translate from experimental studies suggesting that exposure to may interfere pregnancy. This is also true compounds have been introduced replace known phthalates. Further should take into account human evidence better potential underlying mechanisms disruption by

Language: Английский

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Pyrethroids and developmental neurotoxicity - A critical review of epidemiological studies and supporting mechanistic evidence

Environmental Research, Journal Year: 2022, Volume and Issue: 214, P. 113935 - 113935

Published: July 20, 2022

Pyrethroid metabolites are widely detectable in urine from the general population, including pregnant women and children. Pyrethroids neurotoxic suggested endocrine disruptors. Exposure during vulnerable developmental time windows may have long-term impacts on neurodevelopment. To evaluate epidemiological evidence for neurodevelopmental effects related to prenatal childhood pyrethroid exposure a systematic review assess biological plausibility by evaluating mechanistic evidence. We searched PubMed Web of Science up September 1, 2021 included original studies published English which was measured or estimated pregnancy associations with outcomes children were investigated. The Navigation Guide Systematic Review Methodology used For evidence, we focused relevant key events (KEs) Adverse Outcome Pathways (AOPs) using OECD-supported AOP-wiki platform. A search combining KEs pyrethroids, 26 individual compounds, performed ToxCast database. Twenty-five met inclusion criteria, 17 presented findings exposure, 10 two both windows. overall body rated as “moderate quality” “sufficient evidence” an association between adverse rating “low “limited because cross-sectional study design. Regarding found that pyrethroids able interfere established AOPs neurodevelopmental. strongest interference thyroid hormone (TH) function. probably human neurotoxicants neurodevelopment likely at levels occurring population. Preventive measures reduce among warranted.

Language: Английский

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Endocrine Disrupting Chemicals’ Effects in Children: What We Know and What We Need to Learn?

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11899 - 11899

Published: Oct. 7, 2022

Thousands of natural or manufactured chemicals were defined as endocrine-disrupting (EDCs) because they can interfere with hormone activity and the endocrine system. We summarize discuss what we know still need to learn about EDCs' pathogenic mechanisms action, well effects most common EDCs on system health in childhood. The MEDLINE database (PubMed) was searched 13 May 2022, filtering for EDCs, diseases, children. are a group compounds high heterogeneity, but usually disrupt by mimicking interfering hormones body's hormonal balance through other mechanisms. Individual studied detail, while humans' "cocktail effect" is unclear. In utero, early postnatal life, and/or pubertal development highly susceptible periods exposure. Human epidemiological studies suggest that affect prenatal growth, thyroid function, glucose metabolism, obesity, puberty, fertility several Further needed clarify which mainly act epigenetic processes. A better understanding human crucial developing future regulatory strategies prevent exposure ensure children today, generations, environment.

Language: Английский

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